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RPS6KA3 and H2AFX
Number of citations of the paper that reports this interaction (PMID
21224359
)
5
Data Source:
BioGRID
(enzymatic study)
RPS6KA3
H2AFX
Gene Name
ribosomal protein S6 kinase, 90kDa, polypeptide 3
H2A histone family, member X
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytosol
Chromosome, Telomeric Region
Nucleosome
Nuclear Chromatin
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Site Of Double-strand Break
Extracellular Vesicular Exosome
Molecular Function
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Histone Binding
Protein Heterodimerization Activity
Biological Process
Skeletal System Development
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Cell Cycle
Signal Transduction
Synaptic Transmission
Axon Guidance
Central Nervous System Development
Positive Regulation Of Cell Growth
Response To Lipopolysaccharide
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Translation In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Innate Immune Response
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Neurotrophin TRK Receptor Signaling Pathway
Stress-activated MAPK Cascade
DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
Nucleosome Assembly
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Response To Ionizing Radiation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Pathways
Signaling by GPCR
CREB phosphorylation
Axon guidance
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
CREB phosphorylation
L1CAM interactions
Recycling pathway of L1
CREB phosphorylation through the activation of Ras
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
Gastrin-CREB signalling pathway via PKC and MAPK
RSK activation
Activation of NMDA receptor upon glutamate binding and postsynaptic events
MyD88 dependent cascade initiated on endosome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor 9 (TLR9) Cascade
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
ERK/MAPK targets
Post NMDA receptor activation events
Innate Immune System
Signalling by NGF
MAP kinase activation in TLR cascade
TRIF-mediated TLR3/TLR4 signaling
Senescence-Associated Secretory Phenotype (SASP)
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 4 (TLR4) Cascade
ERK/MAPK targets
Toll Like Receptor 3 (TLR3) Cascade
MAPK targets/ Nuclear events mediated by MAP kinases
Transmission across Chemical Synapses
Nuclear Events (kinase and transcription factor activation)
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
RNF mutants show enhanced WNT signaling and proliferation
Homologous recombination repair of replication-independent double-strand breaks
ATM mediated phosphorylation of repair proteins
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
ATM mediated response to DNA double-strand break
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Chromatin organization
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Senescence-Associated Secretory Phenotype (SASP)
Chromatin modifying enzymes
Recruitment of repair and signaling proteins to double-strand breaks
SIRT1 negatively regulates rRNA Expression
Condensation of Prophase Chromosomes
MRN complex relocalizes to nuclear foci
RNA Polymerase I Promoter Clearance
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
M Phase
Telomere Maintenance
Nucleosome assembly
XAV939 inhibits tankyrase, stabilizing AXIN
Double-Strand Break Repair
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
RNA Polymerase I Transcription
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Cell Cycle, Mitotic
PRC2 methylates histones and DNA
RMTs methylate histone arginines
TCF dependent signaling in response to WNT
Oxidative Stress Induced Senescence
Homologous Recombination Repair
RNA Polymerase I Promoter Opening
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
32 interactors:
ATP5J
BAD
BARX1
CREB1
CREBBP
EIF3C
ESR1
FGF2
FGFR1
GRIN1
GRIN2D
H2AFX
HIST1H3A
HIST3H3
HMGN1
HMGN2
HTR2A
KRT18
MAGI1
MAPK1
MAPK3
MAPT
MASP1
NEDD4
NFKBIA
NR4A1
PDPK1
PEA15
SHANK1
SMS
STK11
YBX1
45 interactors:
A2M
ACTB
ALG9
ATM
ATR
BARD1
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
DDX21
DHX9
KAT5
MASP1
MCPH1
MDC1
MRE11A
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PPP2R4
PRKDC
QARS
RNF168
RNF8
RPS6KA3
SMARCA4
SSRP1
SUPT16H
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TOPORS
TP53BP1
TSSK6
WRN
XRCC6
Entrez ID
6197
3014
HPRD ID
02092
03465
Ensembl ID
ENSG00000177189
ENSG00000188486
Uniprot IDs
B7ZB17
F5GYC4
P51812
P16104
PDB IDs
4D9T
4D9U
4JG6
4JG7
4JG8
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
Enriched GO Terms of Interacting Partners
?
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Fc Receptor Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Response To Organonitrogen Compound
Immune Response-regulating Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Phospholipase Activity
Regulation Of Phospholipase Activity
Positive Regulation Of Lipase Activity
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cell Differentiation
Innate Immune Response
Cell Death
Death
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Response To Abiotic Stimulus
Regulation Of Immune Response
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Phospholipase C Activity
Response To Organic Substance
Positive Regulation Of Metabolic Process
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cellular Biosynthetic Process
Immune Response
Insulin Receptor Signaling Pathway
Response To Growth Factor
Regulation Of Signal Transduction
Anatomical Structure Morphogenesis
Response To Peptide
Immune System Process
Cell Development
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Kinase Activity
Regulation Of Protein Metabolic Process
Response To Stress
Regulation Of Metabolic Process
Response To Hormone
Cellular Response To Organic Substance
Apoptotic Process
Cellular Response To Insulin Stimulus
Programmed Cell Death
DNA Metabolic Process
Double-strand Break Repair
DNA Repair
Cellular Response To DNA Damage Stimulus
Chromosome Organization
DNA Recombination
Organelle Organization
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To Radiation
Chromatin Organization
Response To Stress
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Chromatin Modification
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Abiotic Stimulus
Telomere Maintenance
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Signal Transduction In Response To DNA Damage
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Histone Modification
Signal Transduction By P53 Class Mediator
Response To Stimulus
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle
Cellular Response To Stimulus
Cellular Protein Modification Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Nitrogen Compound Metabolic Process
Peptidyl-amino Acid Modification
DNA Damage Checkpoint
Peptidyl-lysine Modification
Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
DNA Replication
Regulation Of Gene Expression
Response To Gamma Radiation
Negative Regulation Of Protein Metabolic Process
Histone Acetylation
Double-strand Break Repair Via Nonhomologous End Joining
Tagcloud
?
aberrations
applying
arid2
axin1
cdk15
cps1
creating
deleterious
disruptions
drive
driver
fn1
fusions
genomes
hccs
hnf4a
integrations
intronic
mll4
recurrently
seq
silent
splice
tert
thrap3
transcriptomes
transcriptomic
tsc1
wgs
Tagcloud (Difference)
?
aberrations
applying
arid2
axin1
cdk15
cps1
creating
deleterious
disruptions
drive
driver
fn1
fusions
genomes
hccs
hnf4a
integrations
intronic
mll4
recurrently
seq
silent
splice
tert
thrap3
transcriptomes
transcriptomic
tsc1
wgs
Tagcloud (Intersection)
?