RPS6KA3 and GRIN2D

Number of citations of the paper that reports this interaction (PubMedID 10862698)
0

Data Source:
HPRD (in vivo)

		RPS6KA3	GRIN2D
Description		ribosomal protein S6 kinase A3	glutamate ionotropic receptor NMDA type subunit 2D
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Synapse	Endoplasmic Reticulum Membrane Plasma Membrane Membrane NMDA Selective Glutamate Receptor Complex Presynaptic Membrane Synapse Postsynaptic Membrane Presynaptic Active Zone Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity	Glutamate-gated Receptor Activity NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Glutamate Binding Voltage-gated Monoatomic Cation Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Skeletal System Development Toll-like Receptor Signaling Pathway Signal Transduction Chemical Synaptic Transmission Central Nervous System Development Positive Regulation Of Cell Growth Response To Lipopolysaccharide Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Apoptotic Process Regulation Of Translation In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Startle Response Monoatomic Ion Transport Brain Development Adult Locomotory Behavior Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Regulation Of Sensory Perception Of Pain Positive Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Regulation Of Presynaptic Membrane Potential Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To L-glutamate Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Acetylsalicylic acid Fostamatinib	Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Memantine Orphenadrine Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases		Non-syndromic X-linked mental retardation Coffin-Lowry syndrome (CLS)
GWAS		Refractive error ( 32231278)
Interacting Genes		44 interacting genes: ATM ATP5PF BAD BARX1 CREB1 CREBBP CTNND1 EIF3C ESR1 FBXO7 FGF2 FGFR3 FYN GRIN1 GRIN2D H2AX H3-4 H3C1 HMGN1 HMGN2 HTR2A ILKAP KRT18 MAGI1 MAPK1 MAPK3 MAPT MASP1 MLST8 MTOR NEDD4 NFKBIA NR4A1 PDPK1 PEA15 RPTOR SHANK1 SMS SRC STAT3 STK11 SUMO2 TP53 YBX1	33 interacting genes: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA MAP2 MAP2K2 NANOS1 NF1 PATJ PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3
Entrez ID		6197	2906
HPRD ID		02092	04095
Ensembl ID		ENSG00000177189	ENSG00000105464
Uniprot IDs		A0A384MDW3 B1AXG1 B4DG22 B7ZB17 P51812	O15399 Q59G17
PDB IDs		4D9T 4D9U 4JG6 4JG7 4JG8 4NUS 4NW5 4NW6 5D9K 5D9L 7OPO 8EQ5 8R58 8XEY 8XFY	7YFF 7YFL 7YFM 7YFO 7YFR 8E96 8Y1V 9D37 9D38 9D39 9D3A 9D3B 9D3C
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Autophagy Regulation Of Carbohydrate Catabolic Process Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Pentose-phosphate Shunt Positive Regulation Of ATP Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Intracellular Signaling Cassette Regulation Of NADP Metabolic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Glycolytic Process DNA Damage Response Positive Regulation Of Phosphate Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Biological Quality Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Regulation Of Protein Stability Regulation Of Immune System Process Negative Regulation Of Signal Transduction Regulation Of ATP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cellular Response To Heat Protein Localization To Organelle Regulation Of Cell Population Proliferation Positive Regulation Of Pentose-phosphate Shunt Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Primary Metabolic Process Response To Stress Regulation Of TOR Signaling Regulation Of Small Molecule Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process	Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Synapse Protein Kinase Binding Regulation Of Cytoskeleton Organization Glutamatergic Synapse Regulation Of Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Regulation Of Organelle Organization Regulation Of Biological Quality Regulation Of Long-term Neuronal Synaptic Plasticity Cytosol Plasma Membrane Cytoplasm Regulation Of MAPK Cascade Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Chemical Synaptic Transmission Neuron Apoptotic Process Dendrite Cell Junction Receptor Clustering Trans-synaptic Signaling Neuron Projection Regulation Of Anatomical Structure Morphogenesis Regulation Of Transport Synaptic Signaling Response To Morphine Diacylglycerol-dependent Serine/threonine Kinase Activity Perinuclear Region Of Cytoplasm MAPK Cascade Regulation Of Cellular Localization Schwann Cell Development Synaptic Membrane Regulation Of Neuron Apoptotic Process Positive Regulation Of Synaptic Transmission Postsynaptic Density Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Intracellular Protein Localization Learning Or Memory Learning Negative Regulation Of Protein Ubiquitination Regulation Of Developmental Process Regulation Of Microtubule Cytoskeleton Organization Disordered Domain Specific Binding
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