RPS6KA3 and HMGN2

Number of citations of the paper that reports this interaction (PubMedID 11438671)
62

Data Source:
HPRD (in vitro)

		RPS6KA3	HMGN2
Description		ribosomal protein S6 kinase A3	high mobility group nucleosomal binding domain 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Synapse	Chromatin Extracellular Space Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity	DNA Binding Chromatin Binding RNA Binding Protein Binding Nucleosomal DNA Binding
	Biological Process	Skeletal System Development Toll-like Receptor Signaling Pathway Signal Transduction Chemical Synaptic Transmission Central Nervous System Development Positive Regulation Of Cell Growth Response To Lipopolysaccharide Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Apoptotic Process Regulation Of Translation In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Chromatin Organization Killing Of Cells Of Another Organism Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		Acetylsalicylic acid Fostamatinib
Diseases		Non-syndromic X-linked mental retardation Coffin-Lowry syndrome (CLS)
GWAS		Refractive error ( 32231278)	Rosacea symptom severity ( 29771307)
Interacting Genes		44 interacting genes: ATM ATP5PF BAD BARX1 CREB1 CREBBP CTNND1 EIF3C ESR1 FBXO7 FGF2 FGFR3 FYN GRIN1 GRIN2D H2AX H3-4 H3C1 HMGN1 HMGN2 HTR2A ILKAP KRT18 MAGI1 MAPK1 MAPK3 MAPT MASP1 MLST8 MTOR NEDD4 NFKBIA NR4A1 PDPK1 PEA15 RPTOR SHANK1 SMS SRC STAT3 STK11 SUMO2 TP53 YBX1	14 interacting genes: CEBPA EP300 HMGN1 HPF1 KAT2B MTNR1A PARP1 PRKACA PRKCA RPS6KA3 SRPK2 TERF2 UBC UBE2I
Entrez ID		6197	3151
HPRD ID		02092	01230
Ensembl ID		ENSG00000177189	ENSG00000198830
Uniprot IDs		A0A384MDW3 B1AXG1 B4DG22 B7ZB17 P51812	P05204
PDB IDs		4D9T 4D9U 4JG6 4JG7 4JG8 4NUS 4NW5 4NW6 5D9K 5D9L 7OPO 8EQ5 8R58 8XEY 8XFY
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Autophagy Regulation Of Carbohydrate Catabolic Process Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Pentose-phosphate Shunt Positive Regulation Of ATP Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Intracellular Signaling Cassette Regulation Of NADP Metabolic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Glycolytic Process DNA Damage Response Positive Regulation Of Phosphate Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Biological Quality Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Regulation Of Protein Stability Regulation Of Immune System Process Negative Regulation Of Signal Transduction Regulation Of ATP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cellular Response To Heat Protein Localization To Organelle Regulation Of Cell Population Proliferation Positive Regulation Of Pentose-phosphate Shunt Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Primary Metabolic Process Response To Stress Regulation Of TOR Signaling Regulation Of Small Molecule Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process	Protein Modification Process Nucleoplasm Protein Localization To Chromosome Regulation Of ATP Metabolic Process Chromatin Organization Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Small Molecule Metabolic Process Chromatin Binding N-terminal Peptidyl-lysine Acetylation Response To Hormone Protein Localization To Chromatin Chromatin Remodeling Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Regulation Of Glycolytic Process Regulation Of Gluconeogenesis Macromolecule Metabolic Process Transferase Activity Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation TORC1 Signaling Regulation Of Carbohydrate Catabolic Process Response To Stress Nucleus Internal Protein Amino Acid Acetylation STAT Family Protein Binding Cellular Response To Parathyroid Hormone Stimulus TOR Signaling N-terminal Protein Amino Acid Acetylation Positive Regulation Of Metabolic Process Peptidyl-lysine Acetylation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Learning Or Memory Modification-dependent Protein Catabolic Process Response To Parathyroid Hormone Regulation Of Glucose Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Peptide Hormone Protein Poly-ADP-ribosylation Carbohydrate Biosynthetic Process Cognition Protein Localization To Organelle Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Acetyltransferase Activity
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