RPL18 and IL7R

Number of citations of the paper that reports this interaction (PMID 23151878)
3

Data Source:
BioGRID (unspecified method)

		RPL18	IL7R
Gene Name		ribosomal protein L18	interleukin 7 receptor
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	RNA Binding Structural Constituent Of Ribosome	Antigen Binding Interleukin-7 Receptor Activity Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process	Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Size Positive Regulation Of Gene Expression Cell Growth T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells
Pathways		Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Signaling by Interleukins Interleukin-7 signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)	Multiple sclerosis ( 21244703 19525953 21833088) Primary biliary cirrhosis ( 23000144 21399635) Type 1 diabetes ( 17554260) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		4 interactors: CDKN1A FANCA FANCC IL7R	104 interactors: ALYREF CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 GNB2L1 H1FX HIST1H1C HIST1H1E HIST2H2BE HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MAP4 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787
Entrez ID		6141	3575
HPRD ID		16046	00893
Ensembl ID		ENSG00000063177	ENSG00000168685
Uniprot IDs		F8VWC5 Q07020	D6RGV2 D9N160 P16871
PDB IDs		3J3B	3DI2 3DI3 3UP1
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus Interleukin-7-mediated Signaling Pathway Homeostasis Of Number Of Cells Negative Regulation Of T Cell Mediated Cytotoxicity Intestinal Epithelial Cell Maturation Positive Regulation Of Cell Activation Cellular Response To Stress Cellular Response To UV-B Regulation Of Lymphocyte Activation Stress-induced Premature Senescence Anatomical Structure Development Negative Regulation Of T Cell Mediated Immunity Regulation Of Cell Activation Lymph Node Development Positive Regulation Of T Cell Differentiation In Thymus Mitotic Cell Cycle Arrest Response To UV-B Intestinal Epithelial Cell Development Immune System Process Developmental Process Regulation Of Protein Import Into Nucleus, Translocation Removal Of Superoxide Radicals Intestinal Epithelial Cell Differentiation Cellular Response To Superoxide Epithelial Cell Maturation DNA Repair Response To Superoxide Response To Arsenic-containing Substance Response To Oxygen Radical Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Senescence Regulation Of T Cell Differentiation In Thymus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To X-ray Developmental Process Involved In Reproduction Response To Hyperoxia Response To Corticosterone Negative Regulation Of Adaptive Immune Response Cellular Response To Stimulus Response To Mineralocorticoid B Cell Proliferation Positive Regulation Of B Cell Proliferation Superoxide Metabolic Process Organ Development Regulation Of Immune Response Columnar/cuboidal Epithelial Cell Development Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA Biosynthetic Process Positive Regulation Of Immune System Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest	MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing RNA Splicing MRNA Processing RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Viral Process RNA Biosynthetic Process SRP-dependent Cotranslational Protein Targeting To Membrane Termination Of RNA Polymerase II Transcription Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein Localization To Endoplasmic Reticulum Viral Life Cycle Cytoplasmic Transport Posttranscriptional Regulation Of Gene Expression MRNA Stabilization RNA 3'-end Processing MRNA 3'-end Processing RNA Catabolic Process Viral Transcription Cellular Metabolic Process Protein Targeting To Membrane DNA-templated Transcription, Termination Protein Targeting Nuclear-transcribed MRNA Catabolic Process Establishment Of Protein Localization To Organelle MRNA Catabolic Process Ribonucleoprotein Complex Assembly Regulation Of Translation Ribonucleoprotein Complex Biogenesis Biosynthetic Process Protein Localization To Organelle Translational Termination Establishment Of Protein Localization To Membrane Intracellular Transport Translational Elongation
Tagcloud ?		19q 19q13 1p 1p36 allelic anaplastic astrocytomas cdnas dbp deleted flj10781 ftl gliomas heterozygosity icmt loh losses mgc4399 microarrays microsatellite oligoastrocytomas oligodendroglial oligodendrogliomas p36 pla2g4c q13 radio srm zin	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		19q 19q13 1p 1p36 allelic anaplastic astrocytomas cdnas dbp deleted flj10781 ftl gliomas heterozygosity icmt loh losses mgc4399 microarrays microsatellite oligoastrocytomas oligodendroglial oligodendrogliomas p36 pla2g4c q13 radio srm zin	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?