RPL10 and YES1

Number of citations of the paper that reports this interaction (PMID 12138090)
5

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		RPL10	YES1
Gene Name		ribosomal protein L10	YES proto-oncogene 1, Src family tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Membrane Cytosolic Large Ribosomal Subunit	Cytoplasm Golgi Apparatus Microtubule Organizing Center Cytosol Actin Filament Plasma Membrane Focal Adhesion Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Enzyme Binding Ion Channel Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process	Cellular Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Blood Coagulation Glucose Transport Cell Differentiation T Cell Costimulation Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Regulation Of Vascular Permeability Innate Immune Response Ephrin Receptor Signaling Pathway Leukocyte Migration Cellular Response To Peptide Hormone Stimulus
Pathways		Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Axon guidance Costimulation by the CD28 family EPHB-mediated forward signaling Signaling by SCF-KIT EPHA-mediated growth cone collapse Regulation of KIT signaling EPH-ephrin mediated repulsion of cells Regulation of signaling by CBL EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Innate Immune System CTLA4 inhibitory signaling CD28 co-stimulation Cytokine Signaling in Immune system PECAM1 interactions Cell surface interactions at the vascular wall Signaling by ERBB2 Signaling by Interleukins Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System
Drugs			Dasatinib
Diseases
GWAS			Pulmonary function in asthmatics ( 23541324)
Protein-Protein Interactions		10 interactors: FYN HCK LYN MAPK6 PRKCA RAD21 SRC TAB1 TBPL1 YES1	49 interactors: ADAM12 ADAM15 C1orf94 CBL CD2AP CD36 CD46 CDH1 CDKN1B CSF1R DLG4 DOK1 EPHB2 FASLG FLT1 FUNDC1 FXR2 GP6 ITGB4 JAK2 KDR KHDRBS1 KIT MST1R NEDD4 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PTK2 PTPRE RASA1 RPL10 SLC9A3R1 SOCS3 SPRR2A SSBP3 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRPV4 TYRO3 ZBTB8A ZNF512B
Entrez ID		6134	7525
HPRD ID		02421	01285
Ensembl ID		ENSG00000147403	ENSG00000176105
Uniprot IDs		P27635	P07947
PDB IDs		2PA2	2HDA
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Autophosphorylation Protein Autophosphorylation Leukocyte Migration Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Innate Immune Response Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Immune Response-regulating Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process T Cell Costimulation Phagocytosis Peptidyl-tyrosine Phosphorylation Phosphate-containing Compound Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Phosphorylation Positive Regulation Of Immune Response Cellular Response To Peptide Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Peptide Immune Response Regulation Of Immune System Process Protein Phosphorylation Defense Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cell Migration Blood Coagulation Regulation Of Immune Response Hemostasis Cell Motility Response To Peptide Hormone Cellular Response To Organonitrogen Compound Regulation Of Cell Activation Peptidyl-amino Acid Modification Response To Peptide Platelet Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Cellular Response To Hormone Stimulus Regulation Of Body Fluid Levels Response To Growth Factor Positive Regulation Of Cell-cell Adhesion	Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Positive Regulation Of Protein Metabolic Process Signaling Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Communication Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Signal Transduction Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Immune System Process Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Innate Immune Response Response To Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Process Locomotion Intracellular Signal Transduction Immune Response Regulation Of Phosphorylation Positive Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Immune System Process Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Organic Substance System Development Regulation Of Cellular Component Movement Regulation Of Immune Response Positive Regulation Of Transferase Activity
Tagcloud ?		a1bg akr1c ambp anxa2 eef1g eif4a1 elucidating eno1 est ests fn1 ftl gnb2l1 gpx4 hcc id1 krt8 ldha libraries rpl13a rpl4 rpl9 rplp0 rps10 rps15 rps21 serpinc1 vim virological	answered antiapoptotic coculture defensive deregulated dramatic heat hyperthermia indicative indispensable insult mechanistically meiotic mta1 naturally negligible nonreceptor pachytene paracrine ps scs sertoli spermatocytes standpoint su6656 testicular testis thereafter varicocele
Tagcloud (Difference) ?		a1bg akr1c ambp anxa2 eef1g eif4a1 elucidating eno1 est ests fn1 ftl gnb2l1 gpx4 hcc id1 krt8 ldha libraries rpl13a rpl4 rpl9 rplp0 rps10 rps15 rps21 serpinc1 vim virological	answered antiapoptotic coculture defensive deregulated dramatic heat hyperthermia indicative indispensable insult mechanistically meiotic mta1 naturally negligible nonreceptor pachytene paracrine ps scs sertoli spermatocytes standpoint su6656 testicular testis thereafter varicocele
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