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AKAP5 and PRKAR2B
Number of citations of the paper that reports this interaction (PMID
8509414
)
18
Data Source:
HPRD
(in vivo, in vitro)
AKAP5
PRKAR2B
Gene Name
A kinase (PRKA) anchor protein 5
protein kinase, cAMP-dependent, regulatory, type II, beta
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Plasma Membrane
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
CAMP-dependent Protein Kinase Complex
Dendritic Spine
Dendritic Shaft
Extracellular Vesicular Exosome
Ciliary Base
Molecular Function
Protein Binding
Calmodulin Binding
Adenylate Cyclase Binding
Protein Kinase A Binding
CAMP-dependent Protein Kinase Inhibitor Activity
CAMP-dependent Protein Kinase Regulator Activity
CAMP Binding
Ubiquitin Protein Ligase Binding
Protein Kinase A Catalytic Subunit Binding
Biological Process
Energy Reserve Metabolic Process
Protein Targeting
Signal Transduction
Synaptic Transmission
Positive Regulation Of Protein Kinase A Signaling
Positive Regulation Of CAMP Biosynthetic Process
Small Molecule Metabolic Process
Regulation Of Insulin Secretion
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Renal Water Homeostasis
Energy Reserve Metabolic Process
Fatty Acid Metabolic Process
Water Transport
Organelle Organization
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Blood Coagulation
Learning
Fibroblast Growth Factor Receptor Signaling Pathway
Activation Of Protein Kinase A Activity
Intracellular Signal Transduction
Small Molecule Metabolic Process
Innate Immune Response
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Insulin Secretion
Transmembrane Transport
Cellular Response To Glucagon Stimulus
Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Integration of energy metabolism
Regulation of insulin secretion
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
Trafficking of AMPA receptors
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Transmission across Chemical Synapses
Ca-dependent events
Signaling by GPCR
CaM pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Hedgehog 'off' state
Signaling by FGFR in disease
Phospholipase C-mediated cascade
Integration of energy metabolism
Signaling by EGFRvIII in Cancer
Regulation of PLK1 Activity at G2/M Transition
PLCG1 events in ERBB2 signaling
DAP12 signaling
Recruitment of mitotic centrosome proteins and complexes
Glucagon signaling in metabolic regulation
Signaling by PDGF
Calmodulin induced events
DAP12 interactions
PKA-mediated phosphorylation of CREB
Opioid Signalling
PKA activation
Factors involved in megakaryocyte development and platelet production
Aquaporin-mediated transport
EGFR interacts with phospholipase C-gamma
Signaling by ERBB2
Signaling by EGFR
PKA-mediated phosphorylation of CREB
Calmodulin induced events
Downstream signal transduction
Signaling by EGFR in Cancer
PKA activation
Mitotic G2-G2/M phases
Organelle biogenesis and maintenance
G2/M Transition
DAG and IP3 signaling
CaM pathway
Downstream signaling of activated FGFR
Loss of Nlp from mitotic centrosomes
DARPP-32 events
Innate Immune System
PKA activation in glucagon signalling
Signalling by NGF
PLC beta mediated events
Vasopressin regulates renal water homeostasis via Aquaporins
Regulation of insulin secretion
Signaling by Ligand-Responsive EGFR Variants in Cancer
Assembly of the primary cilium
G-protein mediated events
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Anchoring of the basal body to the plasma membrane
Cell Cycle, Mitotic
Signaling by FGFR
Loss of proteins required for interphase microtubule organization from the centrosome
Signaling by Hedgehog
PLC-gamma1 signalling
Centrosome maturation
Drugs
Diseases
GWAS
Adverse response to lamotrigine and phenytoin (
22379998
)
Response to antipsychotic treatment (
20195266
)
Protein-Protein Interactions
13 interactors:
ADRB2
CALM1
DLG1
DLG4
GABRB1
GABRB3
IQGAP1
KCNJ2
PPP3CA
PRKAR2A
PRKAR2B
PRKCA
RET
14 interactors:
AKAP1
AKAP10
AKAP11
AKAP14
AKAP4
AKAP5
AKAP7
AKAP9
GNAI3
KIF5B
LASP1
MAATS1
NBEA
TAF12
Entrez ID
9495
5577
HPRD ID
05255
01486
Ensembl ID
ENSG00000179841
ENSG00000005249
Uniprot IDs
P24588
Q6PG46
B3KY43
P31323
PDB IDs
2H9R
3LL8
Enriched GO Terms of Interacting Partners
?
Synaptic Transmission
Cell-cell Signaling
Energy Reserve Metabolic Process
Signaling
Positive Regulation Of Catalytic Activity
Cell Communication
Activation Of Phospholipase C Activity
Epidermal Growth Factor Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Positive Regulation Of Phospholipase C Activity
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Phosphorylation
Cellular Response To Fibroblast Growth Factor Stimulus
Regulation Of Protein Kinase Activity
Response To Fibroblast Growth Factor
Regulation Of Insulin Secretion
Positive Regulation Of Protein Metabolic Process
Regulation Of Kinase Activity
Cellular Response To Organic Substance
Positive Regulation Of Phospholipase Activity
Regulation Of Peptide Hormone Secretion
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Kinase Activity
Positive Regulation Of Phosphorylation
Regulation Of Phospholipase Activity
Positive Regulation Of Lipase Activity
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Protein Modification Process
Regulation Of Hormone Secretion
Positive Regulation Of Transferase Activity
Regulation Of Signaling
Energy Derivation By Oxidation Of Organic Compounds
Regulation Of Cellular Localization
Activation Of Adenylate Cyclase Activity
Positive Regulation Of Hydrolase Activity
Regulation Of Protein Phosphorylation
Regulation Of Catalytic Activity
Positive Regulation Of Metabolic Process
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Adenylate Cyclase Activity
Response To Organic Substance
Positive Regulation Of Cellular Metabolic Process
Response To Stimulus
Regulation Of Muscle Contraction
Regulation Of Protein Secretion
Regulation Of Protein Localization
Generation Of Precursor Metabolites And Energy
Regulation Of Phosphorylation
Regulation Of Protein Kinase A Signaling
Positive Regulation Of Potassium Ion Transport
Regulation Of Potassium Ion Transport
Positive Regulation Of Potassium Ion Transmembrane Transporter Activity
Positive Regulation Of Potassium Ion Transmembrane Transport
Regulation Of Membrane Repolarization
Regulation Of Potassium Ion Transmembrane Transporter Activity
Positive Regulation Of Ion Transport
Regulation Of Potassium Ion Transmembrane Transport
Cellular Response To CAMP
Positive Regulation Of Ion Transmembrane Transporter Activity
Regulation Of Membrane Potential
Positive Regulation Of Transporter Activity
Positive Regulation Of Ion Transmembrane Transport
Regulation Of CAMP Biosynthetic Process
Stress Granule Disassembly
Regulation Of CAMP Metabolic Process
Blood Coagulation
Hemostasis
Response To CAMP
Positive Regulation Of Delayed Rectifier Potassium Channel Activity
Protein Localization
Positive Regulation Of Protein Kinase A Signaling
Regulation Of Ion Transmembrane Transporter Activity
Regulation Of Transmembrane Transporter Activity
Response To Organophosphorus
Plus-end-directed Vesicle Transport Along Microtubule
Regulation Of Body Fluid Levels
Regulation Of Signaling
Synaptic Transmission
Wound Healing
Response To Purine-containing Compound
Cytoplasm Organization
Regulation Of Ion Transport
Regulation Of Delayed Rectifier Potassium Channel Activity
Response To Wounding
Positive Regulation Of Transport
Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization
Sexual Reproduction
Positive Regulation Of Synaptic Transmission, GABAergic
Transport
Tagcloud
?
agouti
albinism
asip
atf1
delta25
dopachrome
edn1
edn3
ednrb
exoc2
exocyst
kitlg
ludwigshafen
mc1r
microphthalmia
oca2
oculocutaneous
pigmentation
prkacg
proopiomelanocortin
slc24a4
slc45a2
tautomerase
tpcn2
tubb3
tyrp1
Tagcloud (Difference)
?
agouti
albinism
asip
atf1
delta25
dopachrome
edn1
edn3
ednrb
exoc2
exocyst
kitlg
ludwigshafen
mc1r
microphthalmia
oca2
oculocutaneous
pigmentation
prkacg
proopiomelanocortin
slc24a4
slc45a2
tautomerase
tpcn2
tubb3
tyrp1
Tagcloud (Intersection)
?