AKAP5 and GABRB3

Number of citations of the paper that reports this interaction (PMID 12595241)
24

Data Source:
HPRD (in vivo, in vitro)

		AKAP5	GABRB3
Gene Name		A kinase (PRKA) anchor protein 5	gamma-aminobutyric acid (GABA) A receptor, beta 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Chloride Channel Complex Postsynaptic Membrane GABA-A Receptor Complex
	Molecular Function	Protein Binding Calmodulin Binding Adenylate Cyclase Binding Protein Kinase A Binding	GABA-A Receptor Activity Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity GABA-gated Chloride Ion Channel Activity
	Biological Process	Energy Reserve Metabolic Process Protein Targeting Signal Transduction Synaptic Transmission Positive Regulation Of Protein Kinase A Signaling Positive Regulation Of CAMP Biosynthetic Process Small Molecule Metabolic Process Regulation Of Insulin Secretion	Transport Signal Transduction Synaptic Transmission Sensory Perception Of Sound Ion Transmembrane Transport Negative Regulation Of Neuron Apoptotic Process Transmembrane Transport Palate Development Inner Ear Receptor Cell Development Innervation Cellular Response To Histamine Cochlea Development Chloride Transmembrane Transport
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses	GABA receptor activation Ion channel transport GABA A receptor activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Orphan transporters Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Cognitive performance ( 19734545) Longevity ( 20834067)
Protein-Protein Interactions		13 interactors: ADRB2 CALM1 DLG1 DLG4 GABRB1 GABRB3 IQGAP1 KCNJ2 PPP3CA PRKAR2A PRKAR2B PRKCA RET	8 interactors: AKAP5 ARFGEF2 GNB2L1 MEOX2 PPP2CA PRKACA PRKCA UBQLN1
Entrez ID		9495	2562
HPRD ID		05255	08844
Ensembl ID		ENSG00000179841	ENSG00000166206
Uniprot IDs		P24588 Q6PG46	B2RCW8 P28472
PDB IDs		2H9R 3LL8
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Energy Reserve Metabolic Process Signaling Positive Regulation Of Catalytic Activity Cell Communication Activation Of Phospholipase C Activity Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phospholipase C Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Protein Kinase Activity Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Cellular Response To Organic Substance Positive Regulation Of Phospholipase Activity Regulation Of Peptide Hormone Secretion Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Hormone Secretion Positive Regulation Of Transferase Activity Regulation Of Signaling Energy Derivation By Oxidation Of Organic Compounds Regulation Of Cellular Localization Activation Of Adenylate Cyclase Activity Positive Regulation Of Hydrolase Activity Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Adenylate Cyclase Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Stimulus Regulation Of Muscle Contraction Regulation Of Protein Secretion Regulation Of Protein Localization Generation Of Precursor Metabolites And Energy Regulation Of Phosphorylation	Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Metabolic Process Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Intracellular Signal Transduction Inactivation Of MAPK Activity Histone H3-T6 Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Positive Regulation Of CAMP Biosynthetic Process Nuclear Envelope Organization Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of MAP Kinase Activity Regulation Of CAMP Biosynthetic Process Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Glucose Import Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macrophage Differentiation Nucleus Organization Endomembrane System Organization Desmosome Organization Cell Death Death Positive Regulation Of Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Energy Reserve Metabolic Process Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Glucose Transport Regulation Of Platelet Aggregation Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of MAPK Cascade Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Lyase Activity Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Regulation Of Rhodopsin Mediated Signaling Pathway
Tagcloud ?			agonistic alpha6 aminobutyric antiepileptic beta3 compromise dravet dysfunctions epilepsy gabaa gabra1 gabra6 gabrd gabrg2 gamma2 gastaut gated gating hyperpolarization infantile insufficiencies lennox myoclonic nonsense pathomechanisms pentamers seizures spasms
Tagcloud (Difference) ?			agonistic alpha6 aminobutyric antiepileptic beta3 compromise dravet dysfunctions epilepsy gabaa gabra1 gabra6 gabrd gabrg2 gamma2 gastaut gated gating hyperpolarization infantile insufficiencies lennox myoclonic nonsense pathomechanisms pentamers seizures spasms
Tagcloud (Intersection) ?