AKAP5 and PPP3CA

Number of citations of the paper that reports this interaction (PMID 7528941)
107

Data Source:
HPRD (in vitro, in vivo)

		AKAP5	PPP3CA
Gene Name		A kinase (PRKA) anchor protein 5	protein phosphatase 3, catalytic subunit, alpha isozyme
Image
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane	Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcineurin Complex Z Disc Sarcolemma
	Molecular Function	Protein Binding Calmodulin Binding Adenylate Cyclase Binding Protein Kinase A Binding	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Energy Reserve Metabolic Process Protein Targeting Signal Transduction Synaptic Transmission Positive Regulation Of Protein Kinase A Signaling Positive Regulation Of CAMP Biosynthetic Process Small Molecule Metabolic Process Regulation Of Insulin Secretion	G1/S Transition Of Mitotic Cell Cycle Response To Amphetamine Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Transition Between Fast And Slow Fiber Dephosphorylation Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Cellular Response To Drug Fc-epsilon Receptor Signaling Pathway T Cell Activation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Insulin Secretion Skeletal Muscle Fiber Development Regulation Of Synaptic Transmission Positive Regulation Of NFAT Protein Import Into Nucleus Response To Calcium Ion Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Response To Glucose Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses	Signaling by GPCR Ca2+ pathway Opioid Signalling DARPP-32 events Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Signaling by Wnt Innate Immune System beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Blood pressure ( 22763476) Corneal structure ( 21979947)
Protein-Protein Interactions		13 interactors: ADRB2 CALM1 DLG1 DLG4 GABRB1 GABRB3 IQGAP1 KCNJ2 PPP3CA PRKAR2A PRKAR2B PRKCA RET	24 interactors: AKAP5 ATP2B4 BAD BCL2 C16orf74 CABIN1 CASP3 CRTC2 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 KCNIP3 MARCH7 MYOZ2 MYOZ3 PPP3R1 PRKCZ RCAN1 RCAN2 SOD1 SYNJ1
Entrez ID		9495	5530
HPRD ID		05255	00234
Ensembl ID		ENSG00000179841	ENSG00000138814
Uniprot IDs		P24588 Q6PG46	Q08209
PDB IDs		2H9R 3LL8	1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Energy Reserve Metabolic Process Signaling Positive Regulation Of Catalytic Activity Cell Communication Activation Of Phospholipase C Activity Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Phospholipase C Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Protein Kinase Activity Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Cellular Response To Organic Substance Positive Regulation Of Phospholipase Activity Regulation Of Peptide Hormone Secretion Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Hormone Secretion Positive Regulation Of Transferase Activity Regulation Of Signaling Energy Derivation By Oxidation Of Organic Compounds Regulation Of Cellular Localization Activation Of Adenylate Cyclase Activity Positive Regulation Of Hydrolase Activity Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Adenylate Cyclase Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Stimulus Regulation Of Muscle Contraction Regulation Of Protein Secretion Regulation Of Protein Localization Generation Of Precursor Metabolites And Energy Regulation Of Phosphorylation	Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Signaling Cell Communication Behavior Cellular Response To Histamine Synaptic Transmission, GABAergic Response To Organic Cyclic Compound Calcineurin-NFAT Signaling Cascade Response To Histamine Single-organism Behavior Regulation Of Neuron Death Cellular Response To Stimulus Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Signal Transduction Inositol Phosphate-mediated Signaling Cellular Response To Ammonium Ion Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Organic Cyclic Compound Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Release Of Cytochrome C From Mitochondria Gamma-aminobutyric Acid Signaling Pathway Regulation Of Cell Activation Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Neurological System Process Positive Regulation Of Cellular Metabolic Process Regulation Of T Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Stimulus Synaptic Transmission Negative Regulation Of Apoptotic Process Cell-cell Signaling Regulation Of Immune System Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Phosphorylation Negative Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Transport Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Death
Tagcloud ?			adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak
Tagcloud (Difference) ?			adenocarcinoma chip coding cre dt ductal fresh g12d intraepithelial kras lincrna1611 lncrnas lsl neoplasia operation pan pancreatic panin pca pdac pdx profilings r172h resected rnas sh tissues tp53 weak
Tagcloud (Intersection) ?