BCL2A1 and NR4A1

Number of citations of the paper that reports this interaction (PubMedID 18835031)
50

Data Source:
HPRD (in vivo)

		BCL2A1	NR4A1
Description		BCL2 related protein A1	nuclear receptor subfamily 4 group A member 1
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GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Cytosol	Chromatin Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Nuclear Speck Nuclear Membrane
	Molecular Function	Protein Binding Channel Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Lipopolysaccharide Binding DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Apoptotic Process Mitochondrial Fusion Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Import Into Nucleus Apoptotic Process Inflammatory Response Signal Transduction Intracellular Receptor Signaling Pathway Detection Of Lipopolysaccharide Endothelial Cell Chemotaxis Skeletal Muscle Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Macrophage Activation Positive Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Fat Cell Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus Non-canonical Inflammasome Complex Assembly
Pathways		Nuclear events stimulated by ALK signaling in cancer Regulation of MITF-M-dependent genes involved in apoptosis	AKT phosphorylates targets in the nucleus Nuclear Receptor transcription pathway Constitutive Signaling by AKT1 E17K in Cancer
Drugs
Diseases
GWAS		Eosinophil count ( 27863252 29403010 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252 29403010 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Primary sclerosing cholangitis ( 27992413) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 29403010)
Interacting Genes		18 interacting genes: APP BAD BAK1 BAX BBC3 BCL2L11 BID BIK BMF BOK CT45A1 FAM9B GRB2 GSK3B HRK NHERF1 NR4A1 PMAIP1	86 interacting genes: ABCA5 ABCB11 ABCC13 ABCC6 ABCG8 AKT1 ANKIB1 ARHGEF10L ARHGEF5 ATM ATXN1 BBS10 BCL2 BCL2A1 BCL2L10 CD2AP CDKN2D CHD1L CHD3 CHEK2 CPT1A CUTA DIABLO EP300 FAF1 FXYD3 GADD45GIP1 GK GLOD4 GLUD1 HADHA HES1 HIF1A HNRNPA2B1 HSP90AB1 KAT2B KRTAP10-1 KRTAP10-5 LONRF1 LSS MAP3K1 MAPK1 MAPK8 MED1 MED31 NACAD NCOA1 NCOA2 NCOA3 NCOR2 NDRG1 NFKB1 NR3C1 PGBD1 PML POLA2 PPARG PPBP PPM1A PRDX4 PRDX6 RBL1 ROBO2 RPL7 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KA6 RTN4 RXRA RXRG SERPINA4 SERPING1 SOCS4 STAT3 SUGT1 TCF4 TP53 TRAF2 TRIM28 TUBB4A VASP VHL YWHAZ ZNF331 ZNF579
Entrez ID		597	3164
HPRD ID		03034	00744
Ensembl ID		ENSG00000140379	ENSG00000123358
Uniprot IDs		Q16548	F5GXF0 P22736 Q6ZMM6
PDB IDs		2VM6 3I1H 3MQP 4ZEQ 5UUK 5UUL 5UUP 5WHH 5WHI 6E3I 6E3J 6MBB 6MBC 6RJP 6VO4 8RPO 9FKY 9FKZ 9FL0 9GIP 9GIQ 9GIR 9GIS 9GIT	2QW4 3V3E 3V3Q 4JGV 4KZI 4KZJ 4KZM 4RE8 4REE 4REF 4RZE 4RZF 4RZG 4WHF 4WHG 6KZ5 6LC1 8WUY 8Y7L
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrion Organization Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Mitochondrial Changes Release Of Cytochrome C From Mitochondria Positive Regulation Of Organelle Organization Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Mitochondrion Organization Regulation Of Apoptotic Process Positive Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Bcl-2 Family Protein Complex Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Apoptotic Process Mitochondrial Outer Membrane Positive Regulation Of Mitochondrial Membrane Permeability Programmed Cell Death Cell Death Positive Regulation Of Membrane Permeability Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein-containing Complex Assembly Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Organelle Organization Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Response To Stress Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Potential Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitochondrion Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Regulation Of Neuron Apoptotic Process	Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process TOR Signaling Positive Regulation Of RNA Metabolic Process TORC1 Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Receptor Signaling Pathway Response To Lipid Peroxisome Proliferator Activated Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Nuclear Receptor Binding Ubiquitin Protein Ligase Binding Programmed Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Death Positive Regulation Of Biosynthetic Process Protein-containing Complex Cellular Response To Stress Positive Regulation Of Macromolecule Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleoplasm Intrinsic Apoptotic Signaling Pathway Response To Nutrient Levels Identical Protein Binding MRNA Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Protein Stability Response To Decreased Oxygen Levels Negative Regulation Of RNA Metabolic Process Response To Hormone Negative Regulation Of Nucleobase-containing Compound Metabolic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Developmental Process Response To Oxygen Levels MRNA Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Primary Metabolic Process
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