BCL2A1 and BAK1

Number of citations of the paper that reports this interaction (PubMedID 10381646)
0

Data Source:
HPRD (two hybrid, in vivo)

		BCL2A1	BAK1
Description		BCL2 related protein A1	BCL2 antagonist/killer 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Cytosol	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Cytosol Membrane Mitochondrial Membrane Pore Complex Bcl-2 Family Protein Complex BAK Complex
	Molecular Function	Protein Binding Channel Activity	Protein Binding Channel Activity Porin Activity Heat Shock Protein Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity Protein-folding Chaperone Binding BH Domain Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Apoptotic Process Mitochondrial Fusion Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Leukocyte Homeostasis B Cell Homeostasis B Cell Apoptotic Process Release Of Cytochrome C From Mitochondria Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection Apoptotic Process Mitochondrial Fusion Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Xenobiotic Stimulus Response To Fungus Response To Mycotoxin Response To UV-C Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Gene Expression Endocrine Pancreas Development Animal Organ Regeneration Positive Regulation Of Protein-containing Complex Assembly Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Monoatomic Ion Transmembrane Transport Cellular Response To Unfolded Protein Cellular Response To UV Limb Morphogenesis Response To Hydrogen Peroxide Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Fibroblast Apoptotic Process Response To Ethanol Positive Regulation Of Proteolysis Regulation Of Mitochondrial Membrane Permeability Post-embryonic Camera-type Eye Morphogenesis Homeostasis Of Number Of Cells Epithelial Cell Proliferation Regulation Of Transport Establishment Of Localization In Cell Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Vagina Development Calcium Ion Transport Into Cytosol Regulation Of Biological Quality Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Involved In Blood Vessel Morphogenesis Regulation Of Intracellular Signal Transduction Positive Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of Apoptotic Signaling Pathway
Pathways		Nuclear events stimulated by ALK signaling in cancer Regulation of MITF-M-dependent genes involved in apoptosis	Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria Pyroptosis
Drugs
Diseases
GWAS		Eosinophil count ( 27863252 29403010 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252 29403010 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Primary sclerosing cholangitis ( 27992413) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 29403010)	Autism spectrum disorder or schizophrenia ( 28540026) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Body mass index ( 26426971) Chronic lymphocytic leukemia ( 24292274 28165464 23770605 22700719) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease or systemic sclerosis ( 32024964) Diastolic blood pressure ( 27841878) Eosinophil count ( 32888494 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Hematological parameters ( 19820697) Lung cancer ( 28604730) Multiple sclerosis and systolic blood pressure (pleiotropy) ( 26920376) Neutrophil percentage of granulocytes ( 27863252) Obesity-related traits ( 23251661) Platelet count ( 29066854 27863252 29403010 32888494 33545615 28031487 20139978 26805783 25705162 24026423 22139419 22423221 23263863) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Schizophrenia ( 30285260) Spleen volume ( 34128465) Sum eosinophil basophil counts ( 27863252) Testicular germ cell tumor ( 23666239 23666240 28604732 28604728 19483681)
Interacting Genes		18 interacting genes: APP BAD BAK1 BAX BBC3 BCL2L11 BID BIK BMF BOK CT45A1 FAM9B GRB2 GSK3B HRK NHERF1 NR4A1 PMAIP1	20 interacting genes: ARHGDIA BAX BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BID DBN1 ERN1 HERC1 HSD17B4 HSPD1 MCL1 MFN1 NFKBIB TP53 UBE3A VDAC1 VDAC2
Entrez ID		597	578
HPRD ID		03034	02744
Ensembl ID		ENSG00000140379	ENSG00000030110
Uniprot IDs		Q16548	A0A0S2Z391 Q16611
PDB IDs		2VM6 3I1H 3MQP 4ZEQ 5UUK 5UUL 5UUP 5WHH 5WHI 6E3I 6E3J 6MBB 6MBC 6RJP 6VO4 8RPO 9FKY 9FKZ 9FL0 9GIP 9GIQ 9GIR 9GIS 9GIT	1BXL 2IMS 2IMT 2JBY 2JCN 2LP8 2M5B 2XPX 2YV6 3I1H 3QBR 4D2L 4U2U 4U2V 4UF1 5AJK 5FMI 5FMK 5VWV 5VWW 5VWX 5VWY 5VWZ 5VX0 5VX1 6ODH 6UXM 6UXN 6UXO 6UXP 6UXQ 6UXR 7K02 7LK4 7M5A 7M5B 7OFM 7OFO 8CZF 8CZG 8CZH 8GSV 8IGC 8IVB 8SRX 8SRY 8UKY 8Y1Y 8Y1Z
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrion Organization Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Mitochondrial Changes Release Of Cytochrome C From Mitochondria Positive Regulation Of Organelle Organization Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Mitochondrion Organization Regulation Of Apoptotic Process Positive Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Bcl-2 Family Protein Complex Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Apoptotic Process Mitochondrial Outer Membrane Positive Regulation Of Mitochondrial Membrane Permeability Programmed Cell Death Cell Death Positive Regulation Of Membrane Permeability Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein-containing Complex Assembly Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Organelle Organization Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Response To Stress Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Potential Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitochondrion Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Regulation Of Neuron Apoptotic Process	Apoptotic Mitochondrial Changes Release Of Cytochrome C From Mitochondria Mitochondrion Organization Mitochondrial Outer Membrane Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Channel Activity Bcl-2 Family Protein Complex Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death BH3 Domain Binding Negative Regulation Of Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Programmed Cell Death Regulation Of Membrane Permeability Pore Complex Apoptotic Process Mitochondrial Membrane Programmed Cell Death Cell Death Mitochondrial Membrane Organization Mitochondrion Mitochondrial Fusion Regulation Of Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Mitochondrial Membrane Potential Regulation Of Programmed Cell Death Positive Regulation Of Mitochondrial Membrane Permeability Cellular Response To Stress Positive Regulation Of Membrane Permeability Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Intrinsic Apoptotic Signaling Pathway DNA Damage Response Negative Regulation Of Autophagy Intracellular Signal Transduction Neuron Apoptotic Process Regulation Of Autophagy Regulation Of Release Of Cytochrome C From Mitochondria Transmembrane Transport Epithelial Cell Apoptotic Process Ovarian Follicle Development Mononuclear Cell Proliferation Leukocyte Apoptotic Process Response To Gamma Radiation Leukocyte Proliferation Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
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