BCL2A1 and BOK

Number of citations of the paper that reports this interaction (PubMedID 9356461)
48

Data Source:
HPRD (two hybrid)

		BCL2A1	BOK
Description		BCL2 related protein A1	BCL2 family apoptosis regulator BOK
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Cytosol	Nucleus Nuclear Outer Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Early Endosome Membrane Mitochondrial Membrane Trans-Golgi Network Membrane Cis-Golgi Network Membrane Recycling Endosome Membrane
	Molecular Function	Protein Binding Channel Activity	Signaling Receptor Binding Protein Binding Channel Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity Protein Dimerization Activity BH Domain Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Apoptotic Process Mitochondrial Fusion Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Release Of Cytochrome C From Mitochondria Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Autophagy Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Oligodendrocyte Differentiation Protein Complex Oligomerization Neuron Apoptotic Process Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Mitochondrial Depolarization Transmembrane Transport Negative Regulation Of Necroptotic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Cisplatin Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Chorionic Trophoblast Cell Proliferation Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Granulosa Cell Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Nuclear events stimulated by ALK signaling in cancer Regulation of MITF-M-dependent genes involved in apoptosis
Drugs
Diseases
GWAS		Eosinophil count ( 27863252 29403010 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252 29403010 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Primary sclerosing cholangitis ( 27992413) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 29403010)	Appendicular lean mass ( 33097823) Brain structure ( 20171287) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Planum temporale asymmetry index ( 31887566) Prostate cancer ( 23535732) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		18 interacting genes: APP BAD BAK1 BAX BBC3 BCL2L11 BID BIK BMF BOK CT45A1 FAM9B GRB2 GSK3B HRK NHERF1 NR4A1 PMAIP1	3 interacting genes: BCL2A1 MCL1 NOA1
Entrez ID		597	666
HPRD ID		03034	05657
Ensembl ID		ENSG00000140379	ENSG00000176720
Uniprot IDs		Q16548	A0A024R4A8 A0A481T0W6 A0A4D6NU76 Q9UMX3
PDB IDs		2VM6 3I1H 3MQP 4ZEQ 5UUK 5UUL 5UUP 5WHH 5WHI 6E3I 6E3J 6MBB 6MBC 6RJP 6VO4 8RPO 9FKY 9FKZ 9FL0 9GIP 9GIQ 9GIR 9GIS 9GIT	6CKV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrion Organization Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Mitochondrial Changes Release Of Cytochrome C From Mitochondria Positive Regulation Of Organelle Organization Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Mitochondrion Organization Regulation Of Apoptotic Process Positive Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Bcl-2 Family Protein Complex Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Apoptotic Process Mitochondrial Outer Membrane Positive Regulation Of Mitochondrial Membrane Permeability Programmed Cell Death Cell Death Positive Regulation Of Membrane Permeability Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein-containing Complex Assembly Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Organelle Organization Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Response To Stress Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Potential Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitochondrion Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Regulation Of Neuron Apoptotic Process	Release Of Cytochrome C From Mitochondria Mitochondrion Organization Mitochondrial Fusion Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Channel Activity Apoptotic Mitochondrial Changes Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Death Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Apoptotic Process Organelle Fusion Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane BH Domain Binding Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway BH3 Domain Binding Matrix Side Of Mitochondrial Inner Membrane Mitochondrial Ribosome Assembly Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Bcl-2 Family Protein Complex Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Organelle Organization Negative Regulation Of Anoikis Ribosome Assembly Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Anoikis Protein Transmembrane Transporter Activity DNA Damage Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Apoptotic Process Cell Fate Determination Negative Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Transmembrane Transport Positive Regulation Of Neuron Apoptotic Process Protein Transmembrane Transport Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
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