BCL2A1 and BMF

Number of citations of the paper that reports this interaction (PubMedID 15694340)
0

Data Source:
BioGRID (unspecified method)

		BCL2A1	BMF
Description		BCL2 related protein A1	Bcl2 modifying factor
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Cytosol	Mitochondrial Outer Membrane Cytosol Plasma Membrane Myosin Complex
	Molecular Function	Protein Binding Channel Activity	Protein Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Apoptotic Process Mitochondrial Fusion Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Apoptotic Process Negative Regulation Of Autophagy Positive Regulation Of Protein-containing Complex Assembly Cellular Response To UV Positive Regulation Of Apoptotic Process Anoikis Positive Regulation Of Release Of Cytochrome C From Mitochondria
Pathways		Nuclear events stimulated by ALK signaling in cancer Regulation of MITF-M-dependent genes involved in apoptosis	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of BMF and translocation to mitochondria
Drugs
Diseases
GWAS		Eosinophil count ( 27863252 29403010 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252 29403010 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Primary sclerosing cholangitis ( 27992413) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 29403010)	B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Chronic lymphocytic leukemia ( 24292274 26956414 28165464) Dehydroepiandrosterone sulphate levels ( 21533175) Endometrial cancer ( 27135401 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Ewing sarcoma ( 22327514) Hip circumference adjusted for BMI ( 34021172) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		18 interacting genes: APP BAD BAK1 BAX BBC3 BCL2L11 BID BIK BMF BOK CT45A1 FAM9B GRB2 GSK3B HRK NHERF1 NR4A1 PMAIP1	26 interacting genes: AQP1 BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BCL2L2-PABPN1 CTAG1A CTAG1B CXCL9 DYNLL1 DYNLL2 GPSM3 LCN2 MAPK8 MCL1 MGAT5B MYO5A NNMT RECK REL SEC14L4 SHC3 TCF12 TFIP11 TRIM54
Entrez ID		597	90427
HPRD ID		03034	05881
Ensembl ID		ENSG00000140379	ENSG00000104081
Uniprot IDs		Q16548	Q96LC9
PDB IDs		2VM6 3I1H 3MQP 4ZEQ 5UUK 5UUL 5UUP 5WHH 5WHI 6E3I 6E3J 6MBB 6MBC 6RJP 6VO4 8RPO 9FKY 9FKZ 9FL0 9GIP 9GIQ 9GIR 9GIS 9GIT	7CNU 8IQK 8IQL 8IQM 8R58
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrion Organization Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Mitochondrial Changes Release Of Cytochrome C From Mitochondria Positive Regulation Of Organelle Organization Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Mitochondrion Organization Regulation Of Apoptotic Process Positive Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Bcl-2 Family Protein Complex Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Apoptotic Process Mitochondrial Outer Membrane Positive Regulation Of Mitochondrial Membrane Permeability Programmed Cell Death Cell Death Positive Regulation Of Membrane Permeability Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein-containing Complex Assembly Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Organelle Organization Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Response To Stress Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Potential Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitochondrion Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Regulation Of Neuron Apoptotic Process	Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Channel Activity Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Bcl-2 Family Protein Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage BH3 Domain Binding Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Mitochondrial Outer Membrane Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Damage Response Mitochondrion Organization Negative Regulation Of Apoptotic Process Negative Regulation Of Anoikis Negative Regulation Of Programmed Cell Death Dendritic Cell Apoptotic Process Cellular Response To Stress Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Microtubule Associated Complex Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Stress Programmed Cell Death Cell Death Cell Surface Receptor Signaling Pathway Negative Regulation Of Dendritic Cell Apoptotic Process Response To Reactive Oxygen Species Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Mitochondrial Fusion TRNA Threonylcarbamoyladenosine Metabolic Process Response To Radiation Response To Hydrogen Peroxide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To External Biotic Stimulus Programmed Cell Death Involved In Cell Development Regulation Of Neuron Apoptotic Process Negative Regulation Of Autophagy Cytoplasmic Dynein Complex Cellular Response To Reactive Oxygen Species Nuclear Membrane Identical Protein Binding Cytoplasm Metanephric Descending Thin Limb Development Cellular Response To Decreased Oxygen Levels
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