BCL2A1 and HRK

Number of citations of the paper that reports this interaction (PMID 15694340)
428

Data Source:
HPRD (in vitro)

		BCL2A1	HRK
Gene Name		BCL2-related protein A1	harakiri, BCL2 interacting protein
Image
Gene Ontology Annotations	Cellular Component	Mitochondrial Outer Membrane	Mitochondrion Integral Component Of Membrane
	Molecular Function	Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH Domain Binding	Protein Binding
	Biological Process	Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Apoptotic Process Positive Regulation Of Protein Homooligomerization Positive Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease (age of onset) ( 22005931) Brain structure ( 22504417) Hippocampal volume ( 22504421)
Protein-Protein Interactions		15 interactors: APP BAD BAK1 BAX BBC3 BCL2L11 BID BIK BMF BOK FAM9B GRB2 HRK NR4A1 PMAIP1	7 interactors: BAD BCL2 BCL2A1 BCL2L1 BCL2L2 C1QBP MCL1
Entrez ID		597	8739
HPRD ID		03034	04581
Ensembl ID		ENSG00000140379
Uniprot IDs		Q16548	O00198
PDB IDs		2VM6 3I1H 3MQP	2L58 2L5B
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrion Organization Positive Regulation Of Protein Oligomerization Regulation Of Mitochondrion Organization Regulation Of Protein Oligomerization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Homooligomerization Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Apoptotic Mitochondrial Changes Positive Regulation Of Organelle Organization Apoptotic Process Positive Regulation Of Peptidase Activity Programmed Cell Death Cell Death Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Complex Assembly Activation Of Cysteine-type Endopeptidase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Zymogen Activation Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Peptidase Activity Positive Regulation Of Endopeptidase Activity Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Proteolysis Regulation Of Membrane Permeability Positive Regulation Of Cellular Component Biogenesis Regulation Of Protein Complex Assembly Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Apoptotic Process Regulation Of Proteolysis Protein Processing Positive Regulation Of Intracellular Transport Regulation Of Cell Death Mitochondrial Membrane Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Programmed Cell Death Cell Death Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Anoikis Regulation Of Mitochondrion Organization Regulation Of Anoikis Regulation Of Intracellular Signal Transduction Cellular Response To DNA Damage Stimulus Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Release Of Cytochrome C From Mitochondria Negative Regulation Of Signal Transduction Suppression By Virus Of Host Apoptotic Process Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Signaling Regulation Of Membrane Permeability Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Signal Transduction Cellular Response To Stress Positive Regulation Of Mitochondrion Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Organization Cellular Process Regulating Host Cell Cycle In Response To Virus Regulation Of Signaling Regulation Of Neuron Death Positive Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrion Organization Regulation Of Autophagy
Tagcloud ?		aims apoptotic bax brdu cdk1 cdk4 changed cyclind1 cytometer explored facscan immunoblotting incorporation insulin manners obatoclax oncogene osteoblasts osteoclast poorly precursors promoted promotes remarkably suppressing treating ultimately	a280 acidic adsorptions ahraa amidase amidases amidolysis aprotinin arginine bean bis column daltons differing egta elution elutions ethylenglycol ethylether kallikrein lbti leu lima named pna tentatively tetraacetic trypsin val
Tagcloud (Difference) ?		aims apoptotic bax brdu cdk1 cdk4 changed cyclind1 cytometer explored facscan immunoblotting incorporation insulin manners obatoclax oncogene osteoblasts osteoclast poorly precursors promoted promotes remarkably suppressing treating ultimately	a280 acidic adsorptions ahraa amidase amidases amidolysis aprotinin arginine bean bis column daltons differing egta elution elutions ethylenglycol ethylether kallikrein lbti leu lima named pna tentatively tetraacetic trypsin val
Tagcloud (Intersection) ?