BCL2A1 and BBC3

Number of citations of the paper that reports this interaction (PubMedID 15694340)
0

Data Source:
HPRD (in vitro)

		BCL2A1	BBC3
Description		BCL2 related protein A1	BCL2 binding component 3
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Cytosol	Mitochondrion Mitochondrial Outer Membrane Lysosome Cytosol
	Molecular Function	Protein Binding Channel Activity	Protein Binding ATPase Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Apoptotic Process Mitochondrial Fusion Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Release Of Cytochrome C From Mitochondria Apoptotic Process DNA Damage Response Determination Of Adult Lifespan Positive Regulation Of Protein-containing Complex Assembly Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Lymphocyte Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Thymocyte Apoptotic Process Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Nuclear events stimulated by ALK signaling in cancer Regulation of MITF-M-dependent genes involved in apoptosis	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Eosinophil count ( 27863252 29403010 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252 29403010 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Primary sclerosing cholangitis ( 27992413) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 29403010)	Appendicular lean mass ( 33097823) Monocyte count ( 27863252) White blood cell count ( 32888494)
Interacting Genes		18 interacting genes: APP BAD BAK1 BAX BBC3 BCL2L11 BID BIK BMF BOK CT45A1 FAM9B GRB2 GSK3B HRK NHERF1 NR4A1 PMAIP1	15 interacting genes: BAX BCL2 BCL2A1 BCL2L1 BCL2L2 FBXL20 FHL5 HGS HSD17B13 MCL1 MYPOP NDUFAB1 UBASH3B WDR5 ZNF438
Entrez ID		597	27113
HPRD ID		03034	16165
Ensembl ID		ENSG00000140379	ENSG00000105327
Uniprot IDs		Q16548	Q96PG8 Q9BXH1
PDB IDs		2VM6 3I1H 3MQP 4ZEQ 5UUK 5UUL 5UUP 5WHH 5WHI 6E3I 6E3J 6MBB 6MBC 6RJP 6VO4 8RPO 9FKY 9FKZ 9FL0 9GIP 9GIQ 9GIR 9GIS 9GIT	2M04 4BPI 4BPJ 4BPK 4HNJ 5UUL 6QFM 6QG8 6TQP 7DVD 7P0S 7P9W 7QTX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrion Organization Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Mitochondrial Changes Release Of Cytochrome C From Mitochondria Positive Regulation Of Organelle Organization Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Membrane Permeability Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Mitochondrion Organization Regulation Of Apoptotic Process Positive Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Bcl-2 Family Protein Complex Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Apoptotic Process Mitochondrial Outer Membrane Positive Regulation Of Mitochondrial Membrane Permeability Programmed Cell Death Cell Death Positive Regulation Of Membrane Permeability Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein-containing Complex Assembly Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Organelle Organization Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Response To Stress Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Potential Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitochondrion Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Regulation Of Neuron Apoptotic Process	Release Of Cytochrome C From Mitochondria Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Channel Activity BH3 Domain Binding Apoptotic Mitochondrial Changes Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Mitochondrion Organization Apoptotic Signaling Pathway Mitochondrial Membrane Mitochondrial Fusion Negative Regulation Of Anoikis Programmed Cell Death Involved In Cell Development Regulation Of Anoikis Regulation Of Nitrogen Utilization Retinal Cell Programmed Cell Death Dendritic Cell Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Epithelial Cell Apoptotic Process Ovarian Follicle Development Leukocyte Apoptotic Process Sertoli Cell Proliferation Response To Gamma Radiation Regulation Of Mitochondrial Membrane Permeability Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Developmental Pigmentation Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential DNA Damage Response Negative Regulation Of Apoptotic Signaling Pathway B Cell Apoptotic Process Calcium Ion Transport Into Cytosol Negative Regulation Of Apoptotic Process Regulation Of Developmental Pigmentation Pore Complex Regulation Of Neuron Apoptotic Process Apoptotic Process Negative Regulation Of Programmed Cell Death Motor Neuron Apoptotic Process Regulation Of Motor Neuron Apoptotic Process Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Death
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?