ADRB2 and ADRB3

Number of citations of the paper that reports this interaction (PMID 15123695)
31

Data Source:
HPRD (in vivo)

		ADRB2	ADRB3
Gene Name		adrenoceptor beta 2, surface	adrenoceptor beta 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Lysosome Endosome Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Receptor Complex	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Beta2-adrenergic Receptor Activity Protein Binding Adenylate Cyclase Binding Potassium Channel Regulator Activity Protein Homodimerization Activity Norepinephrine Binding	Beta-adrenergic Receptor Activity Protein Binding Beta3-adrenergic Receptor Activity Beta-3 Adrenergic Receptor Binding Protein Homodimerization Activity Epinephrine Binding Norepinephrine Binding
	Biological Process	Diet Induced Thermogenesis Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Endosome To Lysosome Transport Response To Cold Positive Regulation Of Bone Mineralization Positive Regulation Of Protein Ubiquitination Heat Generation Negative Regulation Of Multicellular Organism Growth Regulation Of Vasodilation Positive Regulation Of MAPK Cascade Bone Resorption Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Smooth Muscle Contraction Brown Fat Cell Differentiation Adrenergic Receptor Signaling Pathway	Diet Induced Thermogenesis Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Carbohydrate Metabolic Process Generation Of Precursor Metabolites And Energy Energy Reserve Metabolic Process Receptor-mediated Endocytosis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Aging Response To Cold Heat Generation Negative Regulation Of Multicellular Organism Growth Eating Behavior Positive Regulation Of MAPK Cascade Response To Antibiotic Brown Fat Cell Differentiation Adrenergic Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Adrenoceptors Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Adrenoceptors Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Betaxolol Metoprolol Norepinephrine Timolol Dipivefrin Sotalol Carteolol Propranolol Labetalol Bisoprolol Epinephrine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Isoproterenol Arbutamine Carvedilol Desipramine Acebutolol Nadolol Levobunolol Metipranolol Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra Procaterol Clenbuterol Bambuterol Oxprenolol Nebivolol Indacaterol Asenapine Droxidopa (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol Bopindolol Bupranolol	Norepinephrine Propranolol Isoproterenol Arbutamine Fenoterol Ephedra Clenbuterol Droxidopa Bopindolol Bupranolol Mirabegron
Diseases
GWAS
Protein-Protein Interactions		88 interactors: ADRB3 ADRBK1 AKAP12 AKAP5 ALDOA ARF4 ARHGAP5 ARHGDIA ARR3 ARRB1 ARRB2 CCKBR CD4 CD68 CD81 CD9 CEACAM1 CNN1 CSK EGLN3 EIF2B1 GMPR2 GNA11 GNA14 GNA15 GNAI2 GNAS GNAT2 GNB1 GNB2L1 GNG2 GNL3L GPR37 GPR56 GPRASP1 GPRC5B GRB2 GRIA3 GRK5 GRK6 HDAC6 HTR4 IL1B IL6R INSR KCNE1 KCNJ6 KCNJ9 KCTD13 MAPK8IP2 MCAM MDM2 NEDD4 NOS1 OPRD1 PLA2G2D PRKCD PTGER1 RAB27A RAB3A RAN RAP2C REL RGS10 RGS11 RGS17 RGS2 RGS20 RGS5 RGS8 RGS9 RHOD RNF41 SLC52A2 SLC9A3R1 SLC9A3R2 SNCG SRC STAT3 STAT4 TSG101 TSHR UCHL1 VAPA VDAC1 VDAC2 VEGFB WNK1	3 interactors: ADRB2 GNAS SRC
Entrez ID		154	155
HPRD ID		00187	00188
Ensembl ID		ENSG00000169252	ENSG00000188778
Uniprot IDs		P07550	A8KAG8 P13945
PDB IDs		1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO	2CDW
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Cell Communication Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Response To Stimulus Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cellular Process Termination Of Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Catalytic Activity Negative Regulation Of Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Blood Coagulation Positive Regulation Of Catalytic Activity Hemostasis Wound Healing Response To Wounding Regulation Of Phosphorylation G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Cell Activation Dopamine Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Protein Phosphorylation Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cell-cell Signaling Regulation Of Cell Motility Positive Regulation Of Hydrolase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Response To Abiotic Stimulus Regulation Of Cellular Amino Acid Metabolic Process	Tissue Homeostasis Multicellular Organismal Homeostasis Adrenergic Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Activation Of Adenylate Cyclase Activity Bone Resorption Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Fatty Acid Positive Regulation Of Lyase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Bone Remodeling Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Response To Fatty Acid Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Developmental Growth Regulation Of CAMP Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Ossification Regulation Of Multicellular Organism Growth Regulation Of CAMP Metabolic Process Tissue Remodeling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Protein Binding Post-embryonic Body Morphogenesis Positive Regulation Of Signal Transduction Cellular Response To Acid Chemical Platelet Activation Homeostatic Process Regulation Of Ossification Cellular Response To Progesterone Stimulus Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Phosphorus Metabolic Process Bone Development Positive Regulation Of Catalytic Activity Negative Regulation Of Growth Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Binding Activation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Developmental Growth Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Blood Circulation Cellular Response To Peptide
Tagcloud ?		acting adrenergic agonists approved arrestin arrestin2 asthma beta2 copd decreasing fda ikappabalpha improving indacaterol inhaled inhibits internalization invasiveness laba mediates obstructive pharmacological precise preventing recognized relieving subsequently transmembrane ultra	adiposity adjusted adra2b apai bsmi circumference considerable covariates dimensionality educational esr1 genotype hip lepr logistic menopause multifactor obesity overweight postmenopausal sign tc tt ucp1 ucp2 unadjusted vdr vietnamese waist
Tagcloud (Difference) ?		acting adrenergic agonists approved arrestin arrestin2 asthma beta2 copd decreasing fda ikappabalpha improving indacaterol inhaled inhibits internalization invasiveness laba mediates obstructive pharmacological precise preventing recognized relieving subsequently transmembrane ultra	adiposity adjusted adra2b apai bsmi circumference considerable covariates dimensionality educational esr1 genotype hip lepr logistic menopause multifactor obesity overweight postmenopausal sign tc tt ucp1 ucp2 unadjusted vdr vietnamese waist
Tagcloud (Intersection) ?