ADRB2 and DCLRE1A

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		ADRB2	DCLRE1A
Description		adrenoceptor beta 2	DNA cross-link repair 1A
Image
GO Annotations	Cellular Component	Nucleus Lysosome Endosome Early Endosome Golgi Apparatus Plasma Membrane Cilium Endosome Membrane Microtubule Cytoskeleton Membrane Apical Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Ciliary Basal Body Receptor Complex Intercellular Bridge Mitotic Spindle Neuronal Dense Core Vesicle	Fibrillar Center Nucleus Nucleoplasm
	Molecular Function	Amyloid-beta Binding G Protein-coupled Receptor Activity Adrenergic Receptor Activity Beta-adrenergic Receptor Activity Beta2-adrenergic Receptor Activity Protein Binding Adenylate Cyclase Binding Potassium Channel Regulator Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Norepinephrine Binding	DNA Binding Damaged DNA Binding Zinc Ion Binding Beta-lactamase Activity Hydrolase Activity 5'-3' DNA Exonuclease Activity Metal Ion Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Transcription By RNA Polymerase II Receptor-mediated Endocytosis Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Endosome To Lysosome Transport Response To Cold Positive Regulation Of Bone Mineralization Heat Generation Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Bone Resorption Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Smooth Muscle Contraction Brown Fat Cell Differentiation Positive Regulation Of Mini Excitatory Postsynaptic Potential Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Blood Vessel Diameter Maintenance AMPA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Autophagosome Maturation Positive Regulation Of Lipophagy Cellular Response To Amyloid-beta Response To Psychosocial Stress	DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Interstrand Cross-link Repair Cell Division
Pathways		Adrenoceptors G alpha (s) signalling events Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Fanconi Anemia Pathway
Drugs		Spermine Amphetamine Betaxolol Bethanidine Isoetharine Cabergoline Metoprolol Metoprolol Olanzapine Atenolol Norepinephrine Timolol Phenylpropanolamine Dipivefrin Sotalol Carteolol Nortriptyline Propranolol Labetalol Bisoprolol Epinephrine Paroxetine Trimipramine Cryptenamine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Ergoloid mesylate Isoprenaline Arbutamine Amiodarone Carvedilol Desipramine Propafenone Acebutolol Nadolol Levobunolol Metipranolol Aripiprazole Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra sinica root Ephedrine Mephentermine Procaterol Clenbuterol Bambuterol Oxprenolol Putrescine Spermidine Celiprolol Nebivolol Indacaterol Bedoradrine NCX 950 Asenapine Droxidopa Bufuralol Protokylol (S)-carazolol Bopindolol Bupranolol Befunolol Olodaterol Vilanterol Viloxazine Arotinolol Doxofylline Racepinephrine Dihydroergocornine DL-Methylephedrine Etafedrine Tulobuterol Levosalbutamol Dihydroergocristine Methoxyphenamine
Diseases		Asthma
GWAS		Chronic obstructive pulmonary disease ( 30804561 33909500) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 30804560) Lymphocyte percentage of white cells ( 27863252) Peak expiratory flow ( 30804560) Systolic blood pressure ( 29615537)
Interacting Genes		162 interacting genes: ABCA7 ADGRG1 ADRB1 ADRB3 AKAP12 AKAP5 ALDOA ARF4 ARHGAP5 ARHGDIA ARR3 ARRB1 ARRB2 ARRDC3 ARV1 ATP6V0B ATP6V0D1 BACE1 BAZ2A BECN2 BSG CAV3 CCKBR CCND2 CD4 CD68 CD81 CD9 CEACAM1 CENPB CLASP2 CLPTM1L CNN1 CRYM CSK DCAF10 DCLRE1A DNAJC14 DRD4 EGLN3 EIF2B1 FBXO17 GBP5 GJC2 GMPR2 GNA11 GNA14 GNA15 GNAI1 GNAI2 GNAS GNAT2 GNB1 GNG2 GNL3L GOLGB1 GPR37 GPRASP1 GPRC5B GRB2 GRIA3 GRK1 GRK2 GRK3 GRK4 GRK5 GRK6 GTF2B HDAC6 HNRNPK HS2ST1 HTR4 IL1B IL6R INSR KCNE1 KCNJ5 KCNJ6 KCNJ9 KCTD13 KLC1 LRATD2 MAPK8IP2 MBOAT2 MBP MCAM MDM2 MFSD12 MFSD2A MGLL MITF MOG MSR1 NAT14 NCOR2 NEDD4 NHERF1 NHERF2 NIPAL2 NOS1 NPTX1 OBP2A OPRD1 PLA2G2D PRDX1 PRKCD PRNP PTGDS PTGER1 PTGES2 RAB14 RAB27A RAB3A RACK1 RAN RAP2C REL RGR RGS10 RGS11 RGS17 RGS2 RGS20 RGS5 RGS8 RGS9 RHOD RIOX1 RNF41 RTN1 SACS SENP3 SI SLC37A1 SLC39A4 SLC52A2 SNCA SNCG SPTBN2 SRC STAT3 STAT4 TCTA TMCC2 TMEM144 TMEM187 TMEM259 TPTE TSG101 TSHR TSPAN7 UCHL1 UST VAPA VDAC1 VDAC2 VEGFB WNK1 YIPF5 YWHAQ ZNF25 ZNF254	4 interacting genes: ADRB2 ERCC6 PIAS1 TP53BP1
Entrez ID		154	9937
HPRD ID		00187	08519
Ensembl ID		ENSG00000169252	ENSG00000198924
Uniprot IDs		P07550 X5DQM5	Q6PJP8
PDB IDs		1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO 4QKX 5D5A 5D5B 5D6L 5JQH 5X7D 6E67 6KR8 6MXT 6N48 6NI3 6OBA 6PRZ 6PS0 6PS1 6PS2 6PS3 6PS4 6PS5 6PS6 7BZ2 7DHI 7DHR 7XK9 7XKA 8GDZ 8GE1 8GE2 8GE3 8GE4 8GE5 8GE6 8GE7 8GE8 8GE9 8GEA 8GEB 8GEC 8GED 8GEE 8GEF 8GEG 8GEH 8GEI 8GEJ 8GFV 8GFW 8GFX 8GFY 8GFZ 8GG0 8GG1 8GG2 8GG3 8GG4 8GG5 8GG6 8GG7 8GG8 8GG9 8GGA 8GGB 8GGC 8GGE 8GGF 8GGI 8GGJ 8GGK 8GGL 8GGM 8GGN 8GGO 8GGP 8GGQ 8GGR 8GGS 8GGT 8GGU 8GGV 8GGW 8GGX 8GGY 8GGZ 8GH0 8GH1 8JJ8 8JJL 8JJO 8UHB 8UNL 8UNM 8UNN 8UNO 8UNP 8UNQ 8UNR 8UNS 8UNT 8UNU 8UNV 8UNW 8UNX 8UNY 8UNZ 8UO0 8UO1 8UO2 8UO3 8UO4 8W1V 8ZBE 8ZCJ 9CHU 9CHV 9CHX	4B87 5AHR 5NZW 5NZX 5NZY 5Q1J 5Q1K 5Q1L 5Q1M 5Q1N 5Q1O 5Q1P 5Q1Q 5Q1R 5Q1S 5Q1T 5Q1U 5Q1V 5Q1W 5Q1X 5Q1Y 5Q1Z 5Q20 5Q22 5Q23 5Q24 5Q25 5Q26 5Q27 5Q28 5Q29 5Q2A 5Q2B 5Q2C 5Q2D 5Q2E 5Q2F 5Q2G 5Q2H 5Q2I 5Q2J 5Q2K 5Q2L 5Q2M 5Q2N 5Q2O 5Q2P 5Q2Q 5Q2R 5Q2S 5Q2T 5Q2U 5Q2V 5Q2W 5Q2X 5Q2Y 5Q2Z 5Q30 5Q31 5Q32 5Q33 5Q34 5Q35 5Q36 5Q37 5Q38 5Q39 5Q3A 5Q3B 5Q3C 5Q3D 5Q3E 5Q3F 5Q3G 5Q3H 5Q3I 5Q3J 5Q3K 5Q3L 5Q3M 5Q3N 5Q3O 5Q3P 5Q3Q 5Q3R 5Q3S 5Q3T 5Q3U 5Q3V 5Q3W 5Q3X 5Q3Y 5Q3Z 5Q40 5Q41 5Q42 5Q43 5Q44 5Q45 5Q46 5Q47 5Q48 5Q49 5Q4A 5Q4B 5Q4C 5Q4D 5Q4E 5Q4F 5Q4G 5Q4H 5Q4I 5Q4J 5Q4K 5Q4L 5Q4M 5Q4N 5Q4O 5Q4P 5Q4Q 5Q4R 5Q4S 5Q4T 5Q4U 5Q4V 5Q4W 5Q4X 5Q4Y 5Q4Z 5Q50 5Q51 5Q52 5Q53 5Q54 5Q55 5Q56 5Q57 5Q58 5Q59 5Q5A 5Q5B 5Q5C 5Q5D 5Q5E 5Q5F 5Q5G 5Q5H 5Q5I 5Q5J 5Q5K 5Q5L 5Q5M 5Q5N 5Q5O 5Q5P 5Q5Q 5Q5R 5Q5S 5Q5T 5Q5U 5Q5V 5Q5W 5Q5X 5Q5Y 5Q5Z 5Q60 5Q61 5Q62 5Q63 5Q64 5Q65 5Q66 5Q67 5Q68 5Q69 5Q6A 5Q6B 5Q6C 5Q6D 5Q6E 5Q6F 5Q6G 5Q6H 5Q6I 5Q6J 5Q6K 5Q6L 5Q6M 5Q6N 5Q6O 5Q6P 5Q6Q 5Q6R 5Q6S 5Q6T 5Q6U 5Q6V 5Q6W 5Q6X 5Q6Y 5Q6Z 5Q70 5Q71 5Q72 5Q73 5Q74 5Q75 5Q76 5Q77 5Q78 5Q79 5Q7A 5Q7B 5Q7C 5Q7D 5Q7E 5Q7F 5Q7G 5Q7H 5Q7I 5Q7J 5Q7K 5Q7L 5Q7M 5Q7N 5Q7O 5Q7P 5Q7Q 5Q7R 5Q7S 5Q7T 5Q7U 5Q7V 5Q7W 5Q7X 5Q7Y 5Q7Z 5Q80 5Q81 5Q82 5Q83 5Q84 5Q85 5Q86 5Q87 5Q88 5Q89 5Q8A 5Q8B 5Q8C 5Q8D 5Q8E 5Q8F 5Q8G 5Q8H 5Q8I 5Q8J 5Q8K 5Q8L 5Q8M 5Q8N 5Q8O 5Q8P 5Q8Q 5Q8R 5Q8S 5Q8T 5Q8U 5Q8V 5Q8W 5Q8X 5Q8Y 5Q8Z 5Q90 5Q91 5Q92 5Q93 5Q94 5Q95 5Q96 5Q97 5Q98 5Q99 5Q9A 5Q9B 5Q9C 5Q9D 5Q9E 5Q9F 5Q9G 5Q9H 5Q9I 5Q9J 5Q9K 5Q9L 5Q9M 5Q9N 5Q9O 5Q9P 5Q9Q 5Q9R 5Q9S 5Q9T 5Q9U 5Q9V 5Q9W 5Q9X 5Q9Y 5Q9Z 5QA0 5QA1 5QA2 8C8B 8C8D 8C8S 8CEW 8CF0 8CG9
Enriched GO Terms of Interacting Partners?		Regulation Of G Protein-coupled Receptor Signaling Pathway Membrane G Protein-coupled Receptor Signaling Pathway Plasma Membrane GTPase Activity Receptor Internalization Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Transport Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Signal Transduction G Protein-coupled Receptor Kinase Activity Regulation Of Biological Quality Receptor-mediated Endocytosis Heterotrimeric G-protein Complex Guanyl Nucleotide Binding Regulation Of MAPK Cascade System Process G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction G-protein Beta/gamma-subunit Complex Binding Regulation Of Intracellular Signal Transduction Beta-adrenergic Receptor Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Transport Import Into Cell Regulation Of Multicellular Organismal Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Protein Domain Specific Binding GTP Binding Regulation Of Monoatomic Ion Transport Desensitization Of G Protein-coupled Receptor Signaling Pathway Beta-2 Adrenergic Receptor Binding Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Transport Acetylcholine Receptor Signaling Pathway Endocytosis Heat Generation Negative Adaptation Of Signaling Pathway Regulation Of Endocytosis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Biological Process Involved In Interaction With Host	Double-strand Break Repair Via Classical Nonhomologous End Joining Double-strand Break Repair Response To X-ray Negative Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Radiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA Recombination DNA Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Mini Excitatory Postsynaptic Potential Nucleic Acid Metabolic Process Protein Localization To Chromosome DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process Fat Cell Differentiation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Beta2-adrenergic Receptor Activity Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair DNA Metabolic Process DNA Damage Response Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Transcription Coregulator Activity Positive Regulation Of Biosynthetic Process Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Norepinephrine Binding Histone H4K20me Methyltransferase Activity Response To Psychosocial Stress Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Response To Stress Positive Regulation Of Lipophagy Regulation Of RNA Biosynthetic Process AMPA Selective Glutamate Receptor Signaling Pathway Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair Positive Regulation Of Metabolic Process
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