ADRB2 and GNAT2

Number of citations: 0 (PubMedID 24561123)
Data Source: BioGRID (protein complementation assay, affinity chromatography technology)

		ADRB2	GNAT2
Name		adrenoceptor beta 2	G protein subunit alpha transducin 2
Structure
GO Annotations	Cellular Component	Nucleus Lysosome Endosome Early Endosome Golgi Apparatus Plasma Membrane Cilium Endosome Membrane Microtubule Cytoskeleton Membrane Apical Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Ciliary Basal Body Receptor Complex Intercellular Bridge Mitotic Spindle Neuronal Dense Core Vesicle	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Membrane Photoreceptor Outer Segment Membrane Cell Projection Synapse
	Molecular Function	Amyloid-beta Binding G Protein-coupled Receptor Activity Adrenergic Receptor Activity Beta-adrenergic Receptor Activity Beta2-adrenergic Receptor Activity Protein Binding Adenylate Cyclase Binding Potassium Channel Regulator Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Norepinephrine Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity GTP Binding G Protein-coupled Photoreceptor Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Transcription By RNA Polymerase II Receptor-mediated Endocytosis Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Endosome To Lysosome Transport Response To Cold Positive Regulation Of Bone Mineralization Heat Generation Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Bone Resorption Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Smooth Muscle Contraction Brown Fat Cell Differentiation Positive Regulation Of Mini Excitatory Postsynaptic Potential Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Blood Vessel Diameter Maintenance AMPA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Autophagosome Maturation Positive Regulation Of Lipophagy Cellular Response To Amyloid-beta Response To Psychosocial Stress	Cell Morphogenesis Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Visual Perception Phototransduction Visual Behavior Intracellular Protein Localization Response To UV Response To Light Stimulus Detection Of Light Stimulus Detection Of Visible Light Response To Light Intensity Gene Expression Dopamine Metabolic Process Retinal Cone Cell Differentiation Camera-type Eye Development Retinal Cone Cell Development Tissue Remodeling Homeostasis Of Number Of Retina Cells Detection Of Light Stimulus Involved In Visual Perception L-glutamate Import Retinal Rod Cell Differentiation Neural Tissue Regeneration Background Adaptation Reactive Gliosis Cone Retinal Bipolar Cell Differentiation
Pathways		Adrenoceptors G alpha (s) signalling events Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Ca2+ pathway Ca2+ pathway G alpha (i) signalling events
Drugs		Spermine Amphetamine Betaxolol Bethanidine Isoetharine Cabergoline Metoprolol Metoprolol Olanzapine Atenolol Norepinephrine Timolol Phenylpropanolamine Dipivefrin Sotalol Carteolol Nortriptyline Propranolol Labetalol Bisoprolol Epinephrine Paroxetine Trimipramine Cryptenamine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Ergoloid mesylate Isoprenaline Arbutamine Amiodarone Carvedilol Desipramine Propafenone Acebutolol Nadolol Levobunolol Metipranolol Aripiprazole Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra sinica root Ephedrine Mephentermine Procaterol Clenbuterol Bambuterol Oxprenolol Putrescine Spermidine Celiprolol Nebivolol Indacaterol Bedoradrine NCX 950 Asenapine Droxidopa Bufuralol Protokylol (S)-carazolol Bopindolol Bupranolol Befunolol Olodaterol Vilanterol Viloxazine Arotinolol Doxofylline Racepinephrine Dihydroergocornine DL-Methylephedrine Etafedrine Tulobuterol Levosalbutamol Dihydroergocristine Methoxyphenamine	None
Diseases		Asthma	Achromatopsia; Rod monochromacy
GWAS		Chronic obstructive pulmonary disease ( 30804561 33909500 ) Eosinophil percentage of white cells ( 32888494 ) FEV1 ( 30804560 ) Lung function (FEV1/FVC) ( 30804560 ) Lymphocyte percentage of white cells ( 27863252 ) Peak expiratory flow ( 30804560 ) Systolic blood pressure ( 29615537 )	BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) Body mass index ( 25673413 26961502 28448500 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index in physically active individuals ( 28448500 ) Hand grip strength ( 29691431 ) Hip circumference ( 25673412 ) Major depressive disorder ( 20125088 ) Obesity ( 23563607 )
Interacting Genes		162 interacting genes: ABCA7 ADGRG1 ADRB1 ADRB3 AKAP12 AKAP5 ALDOA ARF4 ARHGAP5 ARHGDIA ARR3 ARRB1 ARRB2 ARRDC3 ARV1 ATP6V0B ATP6V0D1 BACE1 BAZ2A BECN2 BSG CAV3 CCKBR CCND2 CD4 CD68 CD81 CD9 CEACAM1 CENPB CLASP2 CLPTM1L CNN1 CRYM CSK DCAF10 DCLRE1A DNAJC14 DRD4 EGLN3 EIF2B1 FBXO17 GBP5 GJC2 GMPR2 GNA11 GNA14 GNA15 GNAI1 GNAI2 GNAS GNAT2 GNB1 GNG2 GNL3L GOLGB1 GPR37 GPRASP1 GPRC5B GRB2 GRIA3 GRK1 GRK2 GRK3 GRK4 GRK5 GRK6 GTF2B HDAC6 HNRNPK HS2ST1 HTR4 IL1B IL6R INSR KCNE1 KCNJ5 KCNJ6 KCNJ9 KCTD13 KLC1 LRATD2 MAPK8IP2 MBOAT2 MBP MCAM MDM2 MFSD12 MFSD2A MGLL MITF MOG MSR1 NAT14 NCOR2 NEDD4 NHERF1 NHERF2 NIPAL2 NOS1 NPTX1 OBP2A OPRD1 PLA2G2D PRDX1 PRKCD PRNP PTGDS PTGER1 PTGES2 RAB14 RAB27A RAB3A RACK1 RAN RAP2C REL RGR RGS10 RGS11 RGS17 RGS2 RGS20 RGS5 RGS8 RGS9 RHOD RIOX1 RNF41 RTN1 SACS SENP3 SI SLC37A1 SLC39A4 SLC52A2 SNCA SNCG SPTBN2 SRC STAT3 STAT4 TCTA TMCC2 TMEM144 TMEM187 TMEM259 TPTE TSG101 TSHR TSPAN7 UCHL1 UST VAPA VDAC1 VDAC2 VEGFB WNK1 YIPF5 YWHAQ ZNF25 ZNF254	2 interacting genes: ADRB2 APP
Entrez ID		154	2780
HPRD ID		00187	00762
Ensembl ID		ENSG00000169252	ENSG00000134183
Uniprot IDs		P07550 X5DQM5	P19087 Q5T697
PDB IDs		1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO 4QKX 5D5A 5D5B 5D6L 5JQH 5X7D 6E67 6KR8 6MXT 6N48 6NI3 6OBA 6PRZ 6PS0 6PS1 6PS2 6PS3 6PS4 6PS5 6PS6 7BZ2 7DHI 7DHR 7XK9 7XKA 8GDZ 8GE1 8GE2 8GE3 8GE4 8GE5 8GE6 8GE7 8GE8 8GE9 8GEA 8GEB 8GEC 8GED 8GEE 8GEF 8GEG 8GEH 8GEI 8GEJ 8GFV 8GFW 8GFX 8GFY 8GFZ 8GG0 8GG1 8GG2 8GG3 8GG4 8GG5 8GG6 8GG7 8GG8 8GG9 8GGA 8GGB 8GGC 8GGE 8GGF 8GGI 8GGJ 8GGK 8GGL 8GGM 8GGN 8GGO 8GGP 8GGQ 8GGR 8GGS 8GGT 8GGU 8GGV 8GGW 8GGX 8GGY 8GGZ 8GH0 8GH1 8JJ8 8JJL 8JJO 8UHB 8UNL 8UNM 8UNN 8UNO 8UNP 8UNQ 8UNR 8UNS 8UNT 8UNU 8UNV 8UNW 8UNX 8UNY 8UNZ 8UO0 8UO1 8UO2 8UO3 8UO4 8W1V 8ZBE 8ZCJ 9CHU 9CHV 9CHX	6N84 6N85
GO Terms Enriched among Interactors		Regulation Of G Protein-coupled Receptor Signaling Pathway Membrane G Protein-coupled Receptor Signaling Pathway Plasma Membrane GTPase Activity Receptor Internalization Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Transport Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Signal Transduction G Protein-coupled Receptor Kinase Activity Regulation Of Biological Quality Receptor-mediated Endocytosis Heterotrimeric G-protein Complex Guanyl Nucleotide Binding Regulation Of MAPK Cascade System Process G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction G-protein Beta/gamma-subunit Complex Binding Regulation Of Intracellular Signal Transduction Beta-adrenergic Receptor Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Transport Import Into Cell Regulation Of Multicellular Organismal Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Protein Domain Specific Binding GTP Binding Regulation Of Monoatomic Ion Transport Desensitization Of G Protein-coupled Receptor Signaling Pathway Beta-2 Adrenergic Receptor Binding Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Transport Acetylcholine Receptor Signaling Pathway Endocytosis Heat Generation Negative Adaptation Of Signaling Pathway Regulation Of Endocytosis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Biological Process Involved In Interaction With Host	Neuronal Dense Core Vesicle Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Excitatory Postsynaptic Potential Ionotropic Glutamate Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Glutamate Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Cellular Response To Amyloid-beta Modulation Of Excitatory Postsynaptic Potential Response To Amyloid-beta Regulation Of Multicellular Organism Growth Regulation Of Nervous System Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Mini Excitatory Postsynaptic Potential Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Receptor Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Beta2-adrenergic Receptor Activity Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Early Endosome Regulation Of Developmental Growth Beta-adrenergic Receptor Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Psychosocial Stress Enzyme Binding Norepinephrine Binding Positive Regulation Of Lipophagy Regulation Of Metal Ion Transport AMPA Selective Glutamate Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle