ADRB2 and ARF4

Number of citations of the paper that reports this interaction (PMID 24561123)
0

Data Source:
BioGRID (protein complementation assay)

		ADRB2	ARF4
Gene Name		adrenoceptor beta 2, surface	ADP-ribosylation factor 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Lysosome Endosome Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Receptor Complex	Golgi Apparatus Cytosol Membrane Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	Beta2-adrenergic Receptor Activity Protein Binding Adenylate Cyclase Binding Potassium Channel Regulator Activity Protein Homodimerization Activity Norepinephrine Binding	GTPase Activity Epidermal Growth Factor Receptor Binding Protein Binding GTP Binding
	Biological Process	Diet Induced Thermogenesis Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Endosome To Lysosome Transport Response To Cold Positive Regulation Of Bone Mineralization Positive Regulation Of Protein Ubiquitination Heat Generation Negative Regulation Of Multicellular Organism Growth Regulation Of Vasodilation Positive Regulation Of MAPK Cascade Bone Resorption Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Smooth Muscle Contraction Brown Fat Cell Differentiation Adrenergic Receptor Signaling Pathway	Protein ADP-ribosylation Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Brain Development Protein Transport Vesicle-mediated Transport Cell Migration Activation Of Phospholipase D Activity Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Axon Injury Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Adrenoceptors Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance VxPx cargo-targeting to cilium Assembly of the primary cilium
Drugs		Betaxolol Metoprolol Norepinephrine Timolol Dipivefrin Sotalol Carteolol Propranolol Labetalol Bisoprolol Epinephrine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Isoproterenol Arbutamine Carvedilol Desipramine Acebutolol Nadolol Levobunolol Metipranolol Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra Procaterol Clenbuterol Bambuterol Oxprenolol Nebivolol Indacaterol Asenapine Droxidopa (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol Bopindolol Bupranolol
Diseases
GWAS
Protein-Protein Interactions		88 interactors: ADRB3 ADRBK1 AKAP12 AKAP5 ALDOA ARF4 ARHGAP5 ARHGDIA ARR3 ARRB1 ARRB2 CCKBR CD4 CD68 CD81 CD9 CEACAM1 CNN1 CSK EGLN3 EIF2B1 GMPR2 GNA11 GNA14 GNA15 GNAI2 GNAS GNAT2 GNB1 GNB2L1 GNG2 GNL3L GPR37 GPR56 GPRASP1 GPRC5B GRB2 GRIA3 GRK5 GRK6 HDAC6 HTR4 IL1B IL6R INSR KCNE1 KCNJ6 KCNJ9 KCTD13 MAPK8IP2 MCAM MDM2 NEDD4 NOS1 OPRD1 PLA2G2D PRKCD PTGER1 RAB27A RAB3A RAN RAP2C REL RGS10 RGS11 RGS17 RGS2 RGS20 RGS5 RGS8 RGS9 RHOD RNF41 SLC52A2 SLC9A3R1 SLC9A3R2 SNCG SRC STAT3 STAT4 TSG101 TSHR UCHL1 VAPA VDAC1 VDAC2 VEGFB WNK1	6 interactors: ADRB2 EGFR HNRNPD RAB11FIP3 RCHY1 SDCBP2
Entrez ID		154	378
HPRD ID		00187	03107
Ensembl ID		ENSG00000169252	ENSG00000168374
Uniprot IDs		P07550	P18085
PDB IDs		1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO	1Z6X
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Cell Communication Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Response To Stimulus Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cellular Process Termination Of Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Catalytic Activity Negative Regulation Of Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Blood Coagulation Positive Regulation Of Catalytic Activity Hemostasis Wound Healing Response To Wounding Regulation Of Phosphorylation G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Cell Activation Dopamine Receptor Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Protein Phosphorylation Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cell-cell Signaling Regulation Of Cell Motility Positive Regulation Of Hydrolase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Response To Abiotic Stimulus Regulation Of Cellular Amino Acid Metabolic Process	Regulation Of Vasodilation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Alkanesulfonate Metabolic Process Positive Regulation Of Protein Ubiquitination Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Cellular Protein Metabolic Process Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Circadian Rhythm Regulation Of Protein Metabolic Process Activation Of Phospholipase A2 Activity Positive Regulation Of Protein Modification Process Regulation Of Protein Ubiquitination Endosomal Transport Positive Regulation Of Phospholipase A2 Activity Cellular Localization Response To Cobalamin Response To UV-A Circadian Regulation Of Translation Heat Generation Response To Hydroxyisoflavone Diet Induced Thermogenesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Activation Of Protein Kinase Activity Rhythmic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Catenin Import Into Nucleus Regulation Of Phospholipase A2 Activity Positive Regulation Of Transcription, DNA-templated Regulation Of Superoxide Anion Generation Magnesium Ion Homeostasis Negative Regulation Of Smooth Muscle Contraction Regulation Of Protein Catabolic Process Adrenergic Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Response To Dietary Excess Intracellular Transport Response To Nutrient Levels Positive Regulation Of Gene Expression Cellular Response To Estradiol Stimulus Positive Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Multicellular Organism Growth Protein Insertion Into Membrane
Tagcloud ?		acting adrenergic agonists approved arrestin arrestin2 asthma beta2 copd decreasing fda ikappabalpha improving indacaterol inhaled inhibits internalization invasiveness laba mediates obstructive pharmacological precise preventing recognized relieving subsequently transmembrane ultra	apparatus arf1 arf3 arf5 arf6 arfs carrier coated complementary endocytic endocytosed endosomes former furin golgi gtpases localize overlapping pair recycling redundantly retrograde ribosylation tgn tgn38 transferrin trigger tubulation
Tagcloud (Difference) ?		acting adrenergic agonists approved arrestin arrestin2 asthma beta2 copd decreasing fda ikappabalpha improving indacaterol inhaled inhibits internalization invasiveness laba mediates obstructive pharmacological precise preventing recognized relieving subsequently transmembrane ultra	apparatus arf1 arf3 arf5 arf6 arfs carrier coated complementary endocytic endocytosed endosomes former furin golgi gtpases localize overlapping pair recycling redundantly retrograde ribosylation tgn tgn38 transferrin trigger tubulation
Tagcloud (Intersection) ?