ADRB2 and GNAS

Number of citations: 79 (PubMedID 23798571)
Data Source: BioGRID (affinity chromatography technology, proximity labelling technology, fluorescent resonance energy transfer, affinity chromatography technology)

		ADRB2	GNAS
Name		adrenoceptor beta 2	GNAS complex locus
Structure
GO Annotations	Cellular Component	Nucleus Lysosome Endosome Early Endosome Golgi Apparatus Plasma Membrane Cilium Endosome Membrane Microtubule Cytoskeleton Membrane Apical Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Ciliary Basal Body Receptor Complex Intercellular Bridge Mitotic Spindle Neuronal Dense Core Vesicle	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Apical Plasma Membrane Transport Vesicle Cytoplasmic Vesicle Trans-Golgi Network Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Amyloid-beta Binding G Protein-coupled Receptor Activity Adrenergic Receptor Activity Beta-adrenergic Receptor Activity Beta2-adrenergic Receptor Activity Protein Binding Adenylate Cyclase Binding Potassium Channel Regulator Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Norepinephrine Binding	Nucleotide Binding GTPase Activity G Protein Activity Insulin-like Growth Factor Receptor Binding Protein Binding GTP Binding Adenylate Cyclase Regulator Activity Adenylate Cyclase Activator Activity Hydrolase Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Ionotropic Glutamate Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Transcription By RNA Polymerase II Receptor-mediated Endocytosis Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Endosome To Lysosome Transport Response To Cold Positive Regulation Of Bone Mineralization Heat Generation Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Bone Resorption Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Smooth Muscle Contraction Brown Fat Cell Differentiation Positive Regulation Of Mini Excitatory Postsynaptic Potential Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Blood Vessel Diameter Maintenance AMPA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Autophagosome Maturation Positive Regulation Of Lipophagy Cellular Response To Amyloid-beta Response To Psychosocial Stress	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Renal Water Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Female Pregnancy Sensory Perception Of Chemical Stimulus Sensory Perception Of Smell Protein Secretion Regulation Of Signal Transduction Regulation Of Skeletal Muscle Contraction Response To Prostaglandin E Negative Regulation Of Multicellular Organism Growth Intracellular Transport Developmental Growth Positive Regulation Of Phagocytosis Regulation Of Insulin Secretion Cognition Bone Development Hair Follicle Placode Formation Platelet Aggregation Response To Parathyroid Hormone Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Acidic PH Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Positive Regulation Of Cold-induced Thermogenesis
Pathways		Adrenoceptors G alpha (s) signalling events Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Spermine Amphetamine Betaxolol Bethanidine Isoetharine Cabergoline Metoprolol Metoprolol Olanzapine Atenolol Norepinephrine Timolol Phenylpropanolamine Dipivefrin Sotalol Carteolol Nortriptyline Propranolol Labetalol Bisoprolol Epinephrine Paroxetine Trimipramine Cryptenamine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Ergoloid mesylate Isoprenaline Arbutamine Amiodarone Carvedilol Desipramine Propafenone Acebutolol Nadolol Levobunolol Metipranolol Aripiprazole Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra sinica root Ephedrine Mephentermine Procaterol Clenbuterol Bambuterol Oxprenolol Putrescine Spermidine Celiprolol Nebivolol Indacaterol Bedoradrine NCX 950 Asenapine Droxidopa Bufuralol Protokylol (S)-carazolol Bopindolol Bupranolol Befunolol Olodaterol Vilanterol Viloxazine Arotinolol Doxofylline Racepinephrine Dihydroergocornine DL-Methylephedrine Etafedrine Tulobuterol Levosalbutamol Dihydroergocristine Methoxyphenamine	Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE
Diseases		Asthma	Pseudohypoparathyroidism Progressive osseous heteroplasia (POH) Fibrous dysplasia, polyostotic; Albright hereditary osteodystrophy
GWAS		Chronic obstructive pulmonary disease ( 30804561 33909500 ) Eosinophil percentage of white cells ( 32888494 ) FEV1 ( 30804560 ) Lung function (FEV1/FVC) ( 30804560 ) Lymphocyte percentage of white cells ( 27863252 ) Peak expiratory flow ( 30804560 ) Systolic blood pressure ( 29615537 )	Appendicular lean mass ( 33097823 ) Birth weight ( 31043758 ) Blood pressure ( 21909110 ) Blood urea nitrogen levels ( 31152163 ) Body size at age 10 ( 32376654 ) Colorectal cancer ( 30529582 ) Creatinine levels ( 29124443 ) Diastolic blood pressure ( 29403010 30487518 28739976 27618452 21909115 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) DNA methylation (variation) ( 23725790 ) Estimated glomerular filtration rate ( 31152163 31015462 29124443 ) HDL cholesterol levels ( 32203549 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Hypertension ( 21909115 ) Hyperuricemia ( 29124443 ) Mean arterial pressure ( 29403010 ) Platelet distribution width ( 27863252 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Renal function-related traits (BUN) ( 22797727 ) Response to diuretic therapy in hypertension ( 23753411 ) Serum uric acid levels ( 29124443 ) Sulfasalazine-induced agranulocytosis ( 28762467 ) Systolic blood pressure ( 27618452 28739976 21909115 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Type 2 diabetes ( 30297969 32499647 ) Urate levels ( 31578528 ) Waist circumference adjusted for body mass index ( 26785701 )
Interacting Genes		162 interacting genes: ABCA7 ADGRG1 ADRB1 ADRB3 AKAP12 AKAP5 ALDOA ARF4 ARHGAP5 ARHGDIA ARR3 ARRB1 ARRB2 ARRDC3 ARV1 ATP6V0B ATP6V0D1 BACE1 BAZ2A BECN2 BSG CAV3 CCKBR CCND2 CD4 CD68 CD81 CD9 CEACAM1 CENPB CLASP2 CLPTM1L CNN1 CRYM CSK DCAF10 DCLRE1A DNAJC14 DRD4 EGLN3 EIF2B1 FBXO17 GBP5 GJC2 GMPR2 GNA11 GNA14 GNA15 GNAI1 GNAI2 GNAS GNAT2 GNB1 GNG2 GNL3L GOLGB1 GPR37 GPRASP1 GPRC5B GRB2 GRIA3 GRK1 GRK2 GRK3 GRK4 GRK5 GRK6 GTF2B HDAC6 HNRNPK HS2ST1 HTR4 IL1B IL6R INSR KCNE1 KCNJ5 KCNJ6 KCNJ9 KCTD13 KLC1 LRATD2 MAPK8IP2 MBOAT2 MBP MCAM MDM2 MFSD12 MFSD2A MGLL MITF MOG MSR1 NAT14 NCOR2 NEDD4 NHERF1 NHERF2 NIPAL2 NOS1 NPTX1 OBP2A OPRD1 PLA2G2D PRDX1 PRKCD PRNP PTGDS PTGER1 PTGES2 RAB14 RAB27A RAB3A RACK1 RAN RAP2C REL RGR RGS10 RGS11 RGS17 RGS2 RGS20 RGS5 RGS8 RGS9 RHOD RIOX1 RNF41 RTN1 SACS SENP3 SI SLC37A1 SLC39A4 SLC52A2 SNCA SNCG SPTBN2 SRC STAT3 STAT4 TCTA TMCC2 TMEM144 TMEM187 TMEM259 TPTE TSG101 TSHR TSPAN7 UCHL1 UST VAPA VDAC1 VDAC2 VEGFB WNK1 YIPF5 YWHAQ ZNF25 ZNF254	41 interacting genes: ADCY2 ADCY5 ADCY6 ADORA1 ADRB2 ADRB3 AVPR2 AXIN1 CALM1 CAV3 CFTR CHEK2 CHRM3 CRHR1 CYSLTR2 DRD5 EGFR FZD7 GCGR GLP1R GNGT1 HTR6 LHB LHCGR MSANTD3 MTNR1B NUCB1 NUCB2 OPTN PANX1 PTGDR PTGIR RGS2 RIC8A RIC8B RXFP3 SNX13 TBXA2R TSHR TTC1 VIPR1
Entrez ID		154	2778
HPRD ID		00187	00761
Ensembl ID		ENSG00000169252	ENSG00000087460
Uniprot IDs		P07550 X5DQM5	A0A0A0MR13 A0A0S2Z3H8 A0A0S2Z3S5 A0A590UJF0 A0A590UJQ9 A0A590UK28 A0A7I2V5R6 B0AZR9 O95467 P63092 P84996 Q14455 Q5FWY2 Q5JWD1 Q5JWE9 Q5JWF2
PDB IDs		1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO 4QKX 5D5A 5D5B 5D6L 5JQH 5X7D 6E67 6KR8 6MXT 6N48 6NI3 6OBA 6PRZ 6PS0 6PS1 6PS2 6PS3 6PS4 6PS5 6PS6 7BZ2 7DHI 7DHR 7XK9 7XKA 8GDZ 8GE1 8GE2 8GE3 8GE4 8GE5 8GE6 8GE7 8GE8 8GE9 8GEA 8GEB 8GEC 8GED 8GEE 8GEF 8GEG 8GEH 8GEI 8GEJ 8GFV 8GFW 8GFX 8GFY 8GFZ 8GG0 8GG1 8GG2 8GG3 8GG4 8GG5 8GG6 8GG7 8GG8 8GG9 8GGA 8GGB 8GGC 8GGE 8GGF 8GGI 8GGJ 8GGK 8GGL 8GGM 8GGN 8GGO 8GGP 8GGQ 8GGR 8GGS 8GGT 8GGU 8GGV 8GGW 8GGX 8GGY 8GGZ 8GH0 8GH1 8JJ8 8JJL 8JJO 8UHB 8UNL 8UNM 8UNN 8UNO 8UNP 8UNQ 8UNR 8UNS 8UNT 8UNU 8UNV 8UNW 8UNX 8UNY 8UNZ 8UO0 8UO1 8UO2 8UO3 8UO4 8W1V 8ZBE 8ZCJ 9CHU 9CHV 9CHX	5G53 5UZ7 5VAI 6AU6 6B3J 6E3Y 6E67 6EG8 6GDG 6LI3 6LMK 6LPB 6M1H 6M1I 6NI3 6NIY 6ORV 6P9X 6P9Y 6PB0 6PB1 6UUN 6UUS 6UVA 6VCB 6VN7 6WHC 6WI9 6WPW 6WZG 6X18 6X19 6X1A 6XOX 7AUE 7BB6 7BB7 7BPH 7BW0 7BZ2 7C2E 7CFM 7CFN 7CKW 7CKX 7CKY 7CKZ 7CRH 7CX2 7CX3 7CX4 7CZ5 7D3S 7D7M 7DH5 7DHI 7DHR 7DUQ 7DUR 7DW9 7E14 7E5E 7EPT 7EVM 7EZK 7F0T 7F16 7F1O 7F1Z 7F23 7F24 7F4D 7F4F 7F4H 7F4I 7F53 7F54 7F55 7F58 7JOZ 7JV5 7JVP 7JVQ 7KH0 7KI0 7KI1 7LCI 7LJC 7LJD 7LLL 7LLY 7MBX 7P02 7PIU 7PIV 7RA3 7RBT 7RG9 7RGP 7RMH 7RTB 7S1M 7S3I 7T9I 7T9N 7TMW 7TYF 7TYH 7TYI 7TYL 7TYN 7TYO 7TYW 7TYX 7TYY 7TZF 7UTZ 7V35 7V9L 7V9M 7VAB 7VBH 7VBI 7VUH 7VUI 7VUJ 7VVJ 7VVK 7VVL 7VVM 7VVN 7VVO 7WCM 7WCN 7WQ4 7WU2 7WU3 7WUI 7WUJ 7WUQ 7X2C 7X2D 7X2F 7X8R 7X8S 7XJH 7XJI 7XKD 7XKF 7XOU 7XOV 7XP4 7XP5 7XP6 7XT8 7XT9 7XTB 7XTC 7XTQ 7XW6 7XY6 7XY7 7XZ5 7XZ6 7Y35 7Y36 7Y3G 7YDP 7YP7 7YS6 8E3X 8E3Y 8E3Z 8EL7 8F0J 8F0K 8F2A 8F2B 8F76 8FLQ 8FLR 8FLS 8FLT 8FLU 8FU6 8GD9 8GDA 8GDB 8GDZ 8GE1 8GE2 8GE3 8GE4 8GE5 8GE6 8GE7 8GE8 8GE9 8GEA 8GEB 8GEC 8GED 8GEE 8GEF 8GEG 8GEH 8GEI 8GEJ 8GFV 8GFW 8GFX 8GFY 8GFZ 8GG0 8GG1 8GG2 8GG3 8GG4 8GG5 8GG6 8GG7 8GG8 8GG9 8GGA 8GGB 8GGC 8GGE 8GGF 8GW8 8H4I 8HDO 8HDP 8HIX 8HJ0 8HJ1 8HJ2 8HMP 8HMV 8HTI 8I2G 8INR 8IOC 8IOD 8IQ4 8IQ6 8IRV 8IW4 8IW7 8IW9 8IZB 8J9N 8JHB 8JHI 8JIP 8JIQ 8JIR 8JIS 8JIT 8JIU 8JLJ 8JLK 8JLO 8JLQ 8JLR 8JLZ 8JPP 8JR9 8JSO 8K8J 8KGK 8KH4 8KH5 8PM2 8POK 8QJ2 8SMV 8TB0 8TYW 8U26 8U8F 8UNL 8UNM 8UNN 8UNO 8UNP 8UNQ 8UNR 8UNS 8UNT 8UNU 8UNV 8UNW 8UNX 8UNY 8UNZ 8UO0 8UO1 8UO2 8UO3 8UO4 8UXV 8UXY 8UY0 8UYQ 8VHF 8W88 8W8Q 8W8R 8WC3 8WC4 8WC5 8WC6 8WC7 8WC8 8WG7 8WG8 8WJX 8WW2 8X2K 8X79 8X7A 8XQL 8XQR 8XVE 8XVH 8XVI 8YUT 8YW3 8YW4 8YW5 8YY8 8ZD1 8ZFZ 8ZPS 8ZPT 8ZR5 8ZRK 8ZSJ 8ZSP 8ZSS 8ZSV 9AUC 9BHL 9BHM 9BKK 9EW2 9GYO 9IVG 9J1P 9J31 9JKQ 9JR2 9JR3
GO Terms Enriched among Interactors		Regulation Of G Protein-coupled Receptor Signaling Pathway Membrane G Protein-coupled Receptor Signaling Pathway Plasma Membrane GTPase Activity Receptor Internalization Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Transport Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Signal Transduction G Protein-coupled Receptor Kinase Activity Regulation Of Biological Quality Receptor-mediated Endocytosis Heterotrimeric G-protein Complex Guanyl Nucleotide Binding Regulation Of MAPK Cascade System Process G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction G-protein Beta/gamma-subunit Complex Binding Regulation Of Intracellular Signal Transduction Beta-adrenergic Receptor Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Transport Import Into Cell Regulation Of Multicellular Organismal Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Protein Domain Specific Binding GTP Binding Regulation Of Monoatomic Ion Transport Desensitization Of G Protein-coupled Receptor Signaling Pathway Beta-2 Adrenergic Receptor Binding Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Transport Acetylcholine Receptor Signaling Pathway Endocytosis Heat Generation Negative Adaptation Of Signaling Pathway Regulation Of Endocytosis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Biological Process Involved In Interaction With Host	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Signal Transduction Plasma Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Oxygen-containing Compound Membrane System Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Pressure G-protein Alpha-subunit Binding G Protein-coupled Peptide Receptor Activity Cellular Response To Forskolin Regulation Of System Process Response To Forskolin Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Regulation Of Biological Quality Positive Regulation Of Lyase Activity Regulation Of Blood Circulation Regulation Of Muscle Contraction Positive Regulation Of Cyclase Activity Vascular Process In Circulatory System Regulation Of Signaling Regulation Of Cell Communication Circulatory System Process Positive Regulation Of Blood Pressure Guanyl-nucleotide Exchange Factor Activity Cellular Response To Lipid Cellular Response To Hormone Stimulus Positive Regulation Of Cytosolic Calcium Ion Concentration CAMP Biosynthetic Process Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Regulation Of Muscle System Process Adenylate Cyclase Binding Response To Alcohol Activation Of Adenylate Cyclase Activity Regulation Of Hormone Levels Cellular Response To Peptide Hormone Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Cell-cell Signaling Phosphorus-oxygen Lyase Activity Response To Ketone