ADRB2 and CCND2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		ADRB2	CCND2
Description		adrenoceptor beta 2	cyclin D2
Image
GO Annotations	Cellular Component	Nucleus Lysosome Endosome Early Endosome Golgi Apparatus Plasma Membrane Cilium Endosome Membrane Microtubule Cytoskeleton Membrane Apical Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Ciliary Basal Body Receptor Complex Intercellular Bridge Mitotic Spindle Neuronal Dense Core Vesicle	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Membrane Nuclear Membrane Cyclin D2-CDK4 Complex
	Molecular Function	Amyloid-beta Binding G Protein-coupled Receptor Activity Adrenergic Receptor Activity Beta-adrenergic Receptor Activity Beta2-adrenergic Receptor Activity Protein Binding Adenylate Cyclase Binding Potassium Channel Regulator Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Norepinephrine Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Transcription By RNA Polymerase II Receptor-mediated Endocytosis Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Endosome To Lysosome Transport Response To Cold Positive Regulation Of Bone Mineralization Heat Generation Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Bone Resorption Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Smooth Muscle Contraction Brown Fat Cell Differentiation Positive Regulation Of Mini Excitatory Postsynaptic Potential Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Blood Vessel Diameter Maintenance AMPA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Autophagosome Maturation Positive Regulation Of Lipophagy Cellular Response To Amyloid-beta Response To Psychosocial Stress	G1/S Transition Of Mitotic Cell Cycle Long-term Memory Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Negative Regulation Of Apoptotic Process Cell Division Regulation Of Cell Cycle Cellular Response To X-ray Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Adrenoceptors G alpha (s) signalling events Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity
Drugs		Spermine Amphetamine Betaxolol Bethanidine Isoetharine Cabergoline Metoprolol Metoprolol Olanzapine Atenolol Norepinephrine Timolol Phenylpropanolamine Dipivefrin Sotalol Carteolol Nortriptyline Propranolol Labetalol Bisoprolol Epinephrine Paroxetine Trimipramine Cryptenamine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Ergoloid mesylate Isoprenaline Arbutamine Amiodarone Carvedilol Desipramine Propafenone Acebutolol Nadolol Levobunolol Metipranolol Aripiprazole Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra sinica root Ephedrine Mephentermine Procaterol Clenbuterol Bambuterol Oxprenolol Putrescine Spermidine Celiprolol Nebivolol Indacaterol Bedoradrine NCX 950 Asenapine Droxidopa Bufuralol Protokylol (S)-carazolol Bopindolol Bupranolol Befunolol Olodaterol Vilanterol Viloxazine Arotinolol Doxofylline Racepinephrine Dihydroergocornine DL-Methylephedrine Etafedrine Tulobuterol Levosalbutamol Dihydroergocristine Methoxyphenamine
Diseases		Asthma	Testicular cancer
GWAS		Chronic obstructive pulmonary disease ( 30804561 33909500) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 30804560) Lymphocyte percentage of white cells ( 27863252) Peak expiratory flow ( 30804560) Systolic blood pressure ( 29615537)	Alanine aminotransferase levels ( 34315874) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Blood glucose levels ( 31928498) Brown vs. black hair color ( 30531825) Colorectal cancer ( 24836286 31826910 26151821 30529582 23266556 23263487) Colorectal cancer or advanced adenoma ( 30510241) Glucocorticoid-induced osteonecrosis ( 26265699) Height ( 28270201 28552196) Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 19107115 23377640) Mean corpuscular hemoglobin ( 28017375) Mean corpuscular volume ( 28017375) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 27841878 30578418) QT interval (drug interaction) ( 23459443) Red blood cell count ( 20139978 28017375) Red blood cell traits ( 23222517) Smoking behaviour (cigarettes smoked per day) ( 30679032) Triglyceride levels ( 31928498 32154731 32203549) Type 2 diabetes ( 30297969 31118516 30054458 29358691 28869590 32499647 22885922) Waist circumference ( 31928498)
Interacting Genes		162 interacting genes: ABCA7 ADGRG1 ADRB1 ADRB3 AKAP12 AKAP5 ALDOA ARF4 ARHGAP5 ARHGDIA ARR3 ARRB1 ARRB2 ARRDC3 ARV1 ATP6V0B ATP6V0D1 BACE1 BAZ2A BECN2 BSG CAV3 CCKBR CCND2 CD4 CD68 CD81 CD9 CEACAM1 CENPB CLASP2 CLPTM1L CNN1 CRYM CSK DCAF10 DCLRE1A DNAJC14 DRD4 EGLN3 EIF2B1 FBXO17 GBP5 GJC2 GMPR2 GNA11 GNA14 GNA15 GNAI1 GNAI2 GNAS GNAT2 GNB1 GNG2 GNL3L GOLGB1 GPR37 GPRASP1 GPRC5B GRB2 GRIA3 GRK1 GRK2 GRK3 GRK4 GRK5 GRK6 GTF2B HDAC6 HNRNPK HS2ST1 HTR4 IL1B IL6R INSR KCNE1 KCNJ5 KCNJ6 KCNJ9 KCTD13 KLC1 LRATD2 MAPK8IP2 MBOAT2 MBP MCAM MDM2 MFSD12 MFSD2A MGLL MITF MOG MSR1 NAT14 NCOR2 NEDD4 NHERF1 NHERF2 NIPAL2 NOS1 NPTX1 OBP2A OPRD1 PLA2G2D PRDX1 PRKCD PRNP PTGDS PTGER1 PTGES2 RAB14 RAB27A RAB3A RACK1 RAN RAP2C REL RGR RGS10 RGS11 RGS17 RGS2 RGS20 RGS5 RGS8 RGS9 RHOD RIOX1 RNF41 RTN1 SACS SENP3 SI SLC37A1 SLC39A4 SLC52A2 SNCA SNCG SPTBN2 SRC STAT3 STAT4 TCTA TMCC2 TMEM144 TMEM187 TMEM259 TPTE TSG101 TSHR TSPAN7 UCHL1 UST VAPA VDAC1 VDAC2 VEGFB WNK1 YIPF5 YWHAQ ZNF25 ZNF254	64 interacting genes: ABCB5 ABL1 ADRB2 AKAP8 AKT1 ARAF ARNT AURKA BECN1 CALM1 CALM2 CALM3 CBLC CCNE1 CD44 CDK4 CDK5 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C DMTF1 EPHA2 ERBB2 FBXL2 FGFR4 FZR1 GLIS2 GRM1 H1-1 HGF HIF1A KAT2A KDELR2 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MET NF2 NPDC1 PCGF2 PDGFRA PIK3CA PSMD10 PTEN RAF1 RASSF1 RB1 RELA RUNX1 SERTAD1 STK11 TEAD2 TERT TEX11 TNFRSF1A TSC1 TTYH2
Entrez ID		154	894
HPRD ID		00187	00451
Ensembl ID		ENSG00000169252	ENSG00000118971
Uniprot IDs		P07550 X5DQM5	P30279
PDB IDs		1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO 4QKX 5D5A 5D5B 5D6L 5JQH 5X7D 6E67 6KR8 6MXT 6N48 6NI3 6OBA 6PRZ 6PS0 6PS1 6PS2 6PS3 6PS4 6PS5 6PS6 7BZ2 7DHI 7DHR 7XK9 7XKA 8GDZ 8GE1 8GE2 8GE3 8GE4 8GE5 8GE6 8GE7 8GE8 8GE9 8GEA 8GEB 8GEC 8GED 8GEE 8GEF 8GEG 8GEH 8GEI 8GEJ 8GFV 8GFW 8GFX 8GFY 8GFZ 8GG0 8GG1 8GG2 8GG3 8GG4 8GG5 8GG6 8GG7 8GG8 8GG9 8GGA 8GGB 8GGC 8GGE 8GGF 8GGI 8GGJ 8GGK 8GGL 8GGM 8GGN 8GGO 8GGP 8GGQ 8GGR 8GGS 8GGT 8GGU 8GGV 8GGW 8GGX 8GGY 8GGZ 8GH0 8GH1 8JJ8 8JJL 8JJO 8UHB 8UNL 8UNM 8UNN 8UNO 8UNP 8UNQ 8UNR 8UNS 8UNT 8UNU 8UNV 8UNW 8UNX 8UNY 8UNZ 8UO0 8UO1 8UO2 8UO3 8UO4 8W1V 8ZBE 8ZCJ 9CHU 9CHV 9CHX	6EI2
Enriched GO Terms of Interacting Partners?		Regulation Of G Protein-coupled Receptor Signaling Pathway Membrane G Protein-coupled Receptor Signaling Pathway Plasma Membrane GTPase Activity Receptor Internalization Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Transport Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Signal Transduction G Protein-coupled Receptor Kinase Activity Regulation Of Biological Quality Receptor-mediated Endocytosis Heterotrimeric G-protein Complex Guanyl Nucleotide Binding Regulation Of MAPK Cascade System Process G Protein-coupled Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction G-protein Beta/gamma-subunit Complex Binding Regulation Of Intracellular Signal Transduction Beta-adrenergic Receptor Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Transport Import Into Cell Regulation Of Multicellular Organismal Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Protein Domain Specific Binding GTP Binding Regulation Of Monoatomic Ion Transport Desensitization Of G Protein-coupled Receptor Signaling Pathway Beta-2 Adrenergic Receptor Binding Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Transport Acetylcholine Receptor Signaling Pathway Endocytosis Heat Generation Negative Adaptation Of Signaling Pathway Regulation Of Endocytosis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Biological Process Involved In Interaction With Host	Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Animal Organ Development Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Signal Transduction Protein Kinase Activity Regulation Of Cell Cycle Process Regulation Of Cell Population Proliferation Intracellular Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Intracellular Signaling Cassette Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Kinase Binding Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Developmental Process Positive Regulation Of Signal Transduction Protein Serine Kinase Activity Regulation Of Growth Regulation Of Apoptotic Process Cell Cycle Phase Transition Negative Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Cellular Senescence Regulation Of Catalytic Activity Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Developmental Process Apoptotic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Programmed Cell Death Cell Death Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Cell Differentiation Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Cell Differentiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?