PHB1 and COX6C

Number of citations of the paper that reports this interaction (PubMedID 31536960)
63

Data Source:
BioGRID (biochemical, pull down)

		PHB1	COX6C
Description		prohibitin 1	cytochrome c oxidase subunit 6C
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Early Endosome Plasma Membrane Cell Surface Membrane Mitochondrial Prohibitin Complex Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Membrane Respiratory Chain Complex IV
	Molecular Function	Complement Component C3a Binding Complement Component C3b Binding Transcription Corepressor Activity Protein Binding Enzyme Binding Proteinase Activated Receptor Binding Histone Deacetylase Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Positive Regulation Of Immunoglobulin Production Regulation Of DNA-templated Transcription Mitochondrion Organization Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Cell Growth Positive Regulation Of Interleukin-17 Production RIG-I Signaling Pathway Epigenetic Regulation Of Gene Expression B Cell Activation Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Host-mediated Perturbation Of Viral RNA Genome Replication Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Complement Activation Symbiont Entry Into Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Progesterone Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interleukin-6 DNA Biosynthetic Process T-helper 17 Type Immune Response Antiviral Innate Immune Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway	Generation Of Precursor Metabolites And Energy Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Cellular Respiration
Pathways		RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Processing of SMDT1 Signaling downstream of RAS mutants	TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Complex IV assembly
Drugs		Rocaglamide Didesmethylrocaglamide	Cholic Acid N-Formylmethionine
Diseases
GWAS			Glucose homeostasis traits ( 25524916) Leukocyte telomere length ( 32109421)
Interacting Genes		27 interacting genes: ANXA2 BCAS3 CASC3 CCL5 CD40LG COX6C E2F1 ESR1 HDAC1 LONRF3 MAP1LC3A MAP3K10 MCM2 NCOR1 PTEN RAF1 RB1 RBL1 RBL2 SEC22A SIN3A SMARCA2 SMARCA4 ST14 SUMO4 TP53 XPO1	4 interacting genes: PHB1 PTN RCHY1 SAT1
Entrez ID		5245	1345
HPRD ID		01454	00494
Ensembl ID		ENSG00000167085	ENSG00000164919
Uniprot IDs		A8K401 P35232 Q53FV0	A0A024R9B7 P09669
PDB IDs		8RRH	5Z62
Enriched GO Terms of Interacting Partners?		Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Transcription Regulator Complex Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Chromatin Regulation Of Primary Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Enzyme Binding Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Heterochromatin Formation Rhythmic Process Transcription Repressor Complex Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Epigenetic Regulation Of Gene Expression Circadian Behavior Promoter-specific Chromatin Binding Regulation Of Stem Cell Population Maintenance Negative Regulation Of Gene Expression Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of MiRNA Transcription	DNA Biosynthetic Process Mitochondrial Prohibitin Complex Complement Component C3a Binding Dendrite Regeneration Spermidine Acetylation Putrescine Catabolic Process Spermidine Binding Proteinase Activated Receptor Binding Ossification Involved In Bone Remodeling Diamine N-acetyltransferase Activity Polyamine Catabolic Process T-helper 17 Type Immune Response Error-free Translesion Synthesis Positive Regulation Of Complement Activation Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Host-mediated Perturbation Of Viral RNA Genome Replication RIG-I Signaling Pathway Positive Regulation Of Axon Regeneration Leukocyte Chemotaxis Involved In Inflammatory Response Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Spermidine Metabolic Process Putrescine Metabolic Process Regulation Of Protein Catabolic Process Progesterone Receptor Signaling Pathway Complement Component C3b Binding Dendrite Arborization Negative Regulation Of Long-term Synaptic Potentiation Chondroitin Sulfate Binding Positive Regulation Of Hepatocyte Proliferation Estrous Cycle Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Neuroblast Proliferation Regulation Of Cell Population Proliferation Regulation Of Hepatocyte Proliferation Positive Regulation Of Dendrite Development Polyamine Biosynthetic Process N-acetyltransferase Activity Cellular Response To Interleukin-6 Negative Regulation Of Androgen Receptor Signaling Pathway Ovulation Cycle Polyamine Metabolic Process Response To Interleukin-6 Neuron Projection Arborization Response To Auditory Stimulus Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Humoral Immune Response Positive Regulation Of Stem Cell Differentiation Regulation Of Complement Activation Decidualization
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