PHB1 and MCM2

Number of citations of the paper that reports this interaction (PubMedID 19377303)
62

Data Source:
BioGRID (pull down)

		PHB1	MCM2
Description		prohibitin 1	minichromosome maintenance complex component 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Early Endosome Plasma Membrane Cell Surface Membrane Mitochondrial Prohibitin Complex Extracellular Exosome	Nuclear Chromosome Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Chromosome Nucleolus Cytoplasm Cytosol Cilium MCM Complex CMG Complex
	Molecular Function	Complement Component C3a Binding Complement Component C3b Binding Transcription Corepressor Activity Protein Binding Enzyme Binding Proteinase Activated Receptor Binding Histone Deacetylase Binding Protein Heterodimerization Activity	Nucleotide Binding DNA Binding DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding Histone Binding 3'-5' DNA Helicase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Positive Regulation Of Immunoglobulin Production Regulation Of DNA-templated Transcription Mitochondrion Organization Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Cell Growth Positive Regulation Of Interleukin-17 Production RIG-I Signaling Pathway Epigenetic Regulation Of Gene Expression B Cell Activation Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Host-mediated Perturbation Of Viral RNA Genome Replication Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Complement Activation Symbiont Entry Into Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Progesterone Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interleukin-6 DNA Biosynthetic Process T-helper 17 Type Immune Response Antiviral Innate Immune Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Nucleosome Assembly Apoptotic Process Regulation Of DNA-templated DNA Replication Initiation Cellular Response To Interleukin-4 Cochlea Development Mitotic DNA Replication Initiation
Pathways		RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Processing of SMDT1 Signaling downstream of RAS mutants	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Drugs		Rocaglamide Didesmethylrocaglamide
Diseases
GWAS			Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Red cell distribution width ( 32888494) Refractive error ( 32231278)
Interacting Genes		27 interacting genes: ANXA2 BCAS3 CASC3 CCL5 CD40LG COX6C E2F1 ESR1 HDAC1 LONRF3 MAP1LC3A MAP3K10 MCM2 NCOR1 PTEN RAF1 RB1 RBL1 RBL2 SEC22A SIN3A SMARCA2 SMARCA4 ST14 SUMO4 TP53 XPO1	57 interacting genes: AKAP8 APP ASF1A ATM ATR ATRIP CCNB2 CCNC CDC6 CDC7 CDK1 CDK2 CDK4 CDK6 CDKN2A CPSF1 CSNK2A1 DBF4 ELL EP300 ESCO2 FBXO7 GNB5 GTF2B GTF2H1 H3-4 KAT7 MCM10 MCM3 MCM4 MCM5 MCM6 MCM7 MCPH1 MOB4 MPP3 ORC1 ORC2 ORC4 ORC5 ORC6 P2RX4 PHB1 PHC2 PLK1 PTEN RAD52 RPA1 RPA2 RPA3 RPS4X SIK1 TBP TCEA2 TERF1 TERF2IP UBE3A
Entrez ID		5245	4171
HPRD ID		01454	00303
Ensembl ID		ENSG00000167085	ENSG00000073111
Uniprot IDs		A8K401 P35232 Q53FV0	P49736
PDB IDs		8RRH	4UUZ 5BNV 5BNX 5BO0 5C3I 5JA4 6XTX 6XTY 6YA7 7CIZ 7CJ0 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 8YJF 8YJM 9CAQ
Enriched GO Terms of Interacting Partners?		Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Transcription Regulator Complex Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Chromatin Regulation Of Primary Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Enzyme Binding Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Heterochromatin Formation Rhythmic Process Transcription Repressor Complex Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Epigenetic Regulation Of Gene Expression Circadian Behavior Promoter-specific Chromatin Binding Regulation Of Stem Cell Population Maintenance Negative Regulation Of Gene Expression Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of MiRNA Transcription	DNA Metabolic Process DNA Replication DNA Replication Initiation Nucleic Acid Metabolic Process Nucleoplasm Chromosome, Telomeric Region Regulation Of DNA Replication Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Damage Response Nucleus DNA Repair Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Recombinational Repair DNA Replication Origin Binding Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Recombination Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cell Cycle Phase Transition Protein Localization To Chromosome Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Double-strand Break Repair Via Break-induced Replication Cellular Response To Stress Regulation Of Cell Cycle Process Origin Recognition Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Single-stranded DNA Binding Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Phase Transition Nuclear Origin Of Replication Recognition Complex Regulation Of Primary Metabolic Process Chromosome Chromosome Organization Cell Cycle Phase Transition CMG Complex MCM Complex Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Protein Localization To Site Of Double-strand Break DNA Damage Checkpoint Signaling Telomere Maintenance Response To Stress Mitotic Cell Cycle Phase Transition
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