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PHB1 and SMARCA4
Number of citations of the paper that reports this interaction (PubMedID
12065415
)
36
Data Source:
HPRD
(in vivo)
PHB1
SMARCA4
Description
prohibitin 1
SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Early Endosome
Plasma Membrane
Cell Surface
Membrane
Mitochondrial Prohibitin Complex
Extracellular Exosome
Kinetochore
Chromatin
Fibrillar Center
Extracellular Space
Nucleus
Nucleoplasm
Nucleolus
Membrane
Nuclear Matrix
SWI/SNF Complex
RSC-type Complex
Protein-containing Complex
NpBAF Complex
NBAF Complex
BBAF Complex
GBAF Complex
Molecular Function
Complement Component C3a Binding
Complement Component C3b Binding
Transcription Corepressor Activity
Protein Binding
Enzyme Binding
Proteinase Activated Receptor Binding
Histone Deacetylase Binding
Protein Heterodimerization Activity
RNA Polymerase I Core Promoter Sequence-specific DNA Binding
Transcription Coregulator Binding
P53 Binding
DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Helicase Activity
Protein Binding
ATP Binding
ATP-dependent Activity, Acting On DNA
Hydrolase Activity
ATP Hydrolysis Activity
Tat Protein Binding
Nucleosomal DNA Binding
Histone Binding
Identical Protein Binding
Nuclear Androgen Receptor Binding
DNA Polymerase Binding
ATP-dependent Chromatin Remodeler Activity
Nucleosome Array Spacer Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
Positive Regulation Of Immunoglobulin Production
Regulation Of DNA-templated Transcription
Mitochondrion Organization
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Transcription By Competitive Promoter Binding
Negative Regulation Of Cell Growth
Positive Regulation Of Interleukin-17 Production
RIG-I Signaling Pathway
Epigenetic Regulation Of Gene Expression
B Cell Activation
Negative Regulation Of Protein Catabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Host-mediated Perturbation Of Viral RNA Genome Replication
Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Complement Activation
Symbiont Entry Into Host Cell
Positive Regulation Of Smooth Muscle Cell Proliferation
Protein Stabilization
Progesterone Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interleukin-6
DNA Biosynthetic Process
T-helper 17 Type Immune Response
Antiviral Innate Immune Response
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
RNA Polymerase I Preinitiation Complex Assembly
Neural Retina Development
Chromatin Organization
Nucleosome Disassembly
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Nervous System Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Mitotic Metaphase/anaphase Transition
Positive Regulation Of Wnt Signaling Pathway
Negative Regulation Of Cell Growth
Heterochromatin Formation
Host-mediated Activation Of Viral Transcription
Positive Regulation Of T Cell Differentiation
Negative Regulation Of Cell Differentiation
Positive Regulation Of Cell Differentiation
Positive Regulation Of Myoblast Differentiation
Transcription Initiation-coupled Chromatin Remodeling
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Androgen Receptor Signaling Pathway
Regulation Of G0 To G1 Transition
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Positive Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Glucose Mediated Signaling Pathway
Positive Regulation Of MiRNA Transcription
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Double-strand Break Repair
Regulation Of Nucleotide-excision Repair
Pathways
RAF activation
Signaling by moderate kinase activity BRAF mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Processing of SMDT1
Signaling downstream of RAS mutants
Interleukin-7 signaling
Formation of the beta-catenin:TCF transactivating complex
RMTs methylate histone arginines
Chromatin modifying enzymes
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
EGR2 and SOX10-mediated initiation of Schwann cell myelination
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Negative Regulation of CDH1 Gene Transcription
Regulation of MITF-M-dependent genes involved in pigmentation
Regulation of MITF-M-dependent genes involved in pigmentation
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Formation of the canonical BAF (cBAF) complex
Formation of the polybromo-BAF (pBAF) complex
Formation of the embryonic stem cell BAF (esBAF) complex
Formation of the non-canonical BAF (ncBAF) complex
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Rocaglamide
Didesmethylrocaglamide
Diseases
GWAS
Adult body size (
32376654
)
Apolipoprotein B levels (
32203549
)
Coronary artery disease (
24262325
32469254
33020668
)
Coronary artery disease or ischemic stroke (
24262325
)
Coronary artery disease or large artery stroke (
24262325
)
Disorders of lipid metabolism (
30166351
)
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
Inflammatory skin disease (
25574825
)
LDL cholesterol (
21347282
)
LDL cholesterol levels (
30698716
32203549
)
LDL cholesterol levels in current drinkers (
30698716
)
LDL cholesterol levels in HIV infection (
33109212
)
LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Low density lipoprotein cholesterol levels (
33339817
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
Multiple sclerosis (
31604244
)
Total cholesterol levels (
33339817
)
Interacting Genes
27 interacting genes:
ANXA2
BCAS3
CASC3
CCL5
CD40LG
COX6C
E2F1
ESR1
HDAC1
LONRF3
MAP1LC3A
MAP3K10
MCM2
NCOR1
PTEN
RAF1
RB1
RBL1
RBL2
SEC22A
SIN3A
SMARCA2
SMARCA4
ST14
SUMO4
TP53
XPO1
82 interacting genes:
ACTB
ACTL6A
AHR
AR
ARID1A
ARID1B
ARID2
ATM
BRCA1
BRWD1
CARM1
CBX5
CCNE1
CDK19
CDK8
CDKN2A
CDX2
CEBPA
CEBPB
CHD4
CHFR
CHMP5
CIITA
CREB1
CTNNB1
E2F6
E4F1
ESR1
ETS2
EZH2
FANCA
GATA1
GMNN
H2AX
H3-3A
H3C14
H4C6
HSF1
HSF4
HSPB1
IKZF1
KLF1
MDM2
MED17
MED6
MPHOSPH6
MRTFA
MYC
MYOCD
NR3C1
NR4A2
PABPN1
PALS2
PAX6
PBRM1
PHB1
PTEN
RAP1A
RASSF1
RB1
RBL1
RBL2
RELB
RFXAP
SIN3A
SIN3B
SMARCB1
SMARCC1
SMARCE1
SOX4
SS18
SS18L1
STAT2
STAT3
STK11
SUMO2
TAF15
TMF1
TP53
TTC3
USP7
ZMYND11
Entrez ID
5245
6597
HPRD ID
01454
04459
Ensembl ID
ENSG00000167085
ENSG00000127616
Uniprot IDs
A8K401
P35232
Q53FV0
A0A2R8Y7S2
A7E2E1
B3KNW7
P51532
Q9HBD4
PDB IDs
8RRH
2GRC
2H60
3UVD
5DKD
5EA1
6BGH
6HR2
6LTH
6LTJ
6SY2
6ZS2
7TAB
7TD9
7VDT
7VDV
7VRB
7Y8R
8EB1
8G1Q
8QJR
Enriched GO Terms of Interacting Partners
?
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Transcription Regulator Complex
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Lipid Kinase Activity
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Chromatin Organization
Chromatin
Regulation Of Primary Metabolic Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Enzyme Binding
Regulation Of Gene Expression
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Transcription Corepressor Activity
Positive Regulation Of Stem Cell Population Maintenance
Negative Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Negative Regulation Of Androgen Receptor Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Heterochromatin Formation
Rhythmic Process
Transcription Repressor Complex
Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Process
Epigenetic Regulation Of Gene Expression
Circadian Behavior
Promoter-specific Chromatin Binding
Regulation Of Stem Cell Population Maintenance
Negative Regulation Of Gene Expression
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of MiRNA Transcription
Nucleoplasm
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Chromatin
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Nucleus
Positive Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Chromatin Organization
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Binding
Positive Regulation Of Transcription By RNA Polymerase II
Protein-containing Complex
Regulation Of Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Positive Regulation Of Macromolecule Biosynthetic Process
Chromatin Remodeling
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Biosynthetic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Macromolecule Metabolic Process
SWI/SNF Complex
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Cell Cycle Process
Regulation Of Hemopoiesis
Positive Regulation Of Cell Differentiation
Regulation Of Cell Differentiation
NpBAF Complex
Regulation Of Cell Development
Positive Regulation Of Developmental Process
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Tagcloud (Intersection)
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