FGFR1 and FDPS

Number of citations of the paper that reports this interaction (PMID 12020352)
3

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		FGFR1	FDPS
Gene Name		fibroblast growth factor receptor 1	farnesyl diphosphate synthase
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Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Receptor Complex	Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding Identical Protein Binding Protein Homodimerization Activity	Dimethylallyltranstransferase Activity Geranyltranstransferase Activity Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Skeletal System Development Angiogenesis Ureteric Bud Development In Utero Embryonic Development Organ Induction Neuron Migration Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Transcription, DNA-templated Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Sensory Perception Of Sound Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Ventricular Zone Neuroblast Division Embryonic Limb Morphogenesis Midbrain Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fc-epsilon Receptor Signaling Pathway Inner Ear Morphogenesis Outer Ear Morphogenesis Middle Ear Morphogenesis Chordate Embryonic Development Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Innate Immune Response Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Paraxial Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Cell Maturation Skeletal System Morphogenesis Mesenchymal Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Auditory Receptor Cell Development Branching Involved In Salivary Gland Morphogenesis Lung-associated Mesenchyme Development Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Cholesterol Biosynthetic Process Viral Process Geranyl Diphosphate Biosynthetic Process Small Molecule Metabolic Process Farnesyl Diphosphate Biosynthetic Process
Pathways		Signaling by FGFR in disease Signaling by activated point mutants of FGFR1 Signaling by FGFR1 mutants Signaling by FGFR mutants	Regulation of cholesterol biosynthesis by SREBP (SREBF) Cholesterol biosynthesis Metabolism of lipids and lipoproteins Activation of gene expression by SREBF (SREBP)
Drugs			Pamidronate Zoledronate Alendronate Ibandronate Risedronate Dimethylallyl Diphosphate Isopentyl Pyrophosphate Geranyl Diphosphate ISOPENTENYL PYROPHOSPHATE FARNESYL DIPHOSPHATE GERANYLGERANYL DIPHOSPHATE
Diseases
GWAS
Protein-Protein Interactions		45 interactors: BNIP2 CREBBP CRK CTPS2 EPHA4 ERBB3 FDPS FGF1 FGF17 FGF18 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FLRT3 FRS2 FRS3 GRB14 GRB2 IL17RD ITK KPNB1 MMP2 NCAM1 NCK1 NCK2 NEDD4 NRP1 PIK3R1 PIK3R2 PLCG1 PTK6 RPS6KA1 RPS6KA3 RTN3 SH3BP2 SHC1 SLA SOS1 TNS2 VAV1	3 interactors: ATXN1 EIF4ENIF1 FGFR1
Entrez ID		2260	2224
HPRD ID		00634	00606
Ensembl ID		ENSG00000077782	ENSG00000160752
Uniprot IDs		P11362	P14324
PDB IDs		1AGW 1CVS 1EVT 1FGI 1FGK 1FQ9 1XR0 2CR3 2FGI 3C4F 3DPK 3GQI 3GQL 3JS2 3KRJ 3KRL 3KXX 3KY2 3OJV 3RHX 3TT0 4F63 4F64 4F65	1YQ7 1YV5 1ZW5 2F7M 2F89 2F8C 2F8Z 2F92 2F94 2F9K 2OPM 2OPN 2QIS 2RAH 2VF6 3B7L 3CP6 3N1V 3N1W 3N3L 3N45 3N46 3N49 3N5H 3N5J 3N6K 3RYE 3S4J 4DEM 4GA3 4H5C 4H5D 4H5E
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Fc Receptor Signaling Pathway Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Immune Response Immune Response Cellular Response To Insulin Stimulus Cellular Response To Organic Substance Defense Response Cell Surface Receptor Signaling Pathway Response To Insulin Regulation Of Immune System Process Cellular Response To Peptide Hormone Stimulus Immune System Process Cellular Response To Peptide Signal Transduction Cellular Response To Organonitrogen Compound Response To Organic Substance Signaling Cell Communication Response To Peptide Hormone Response To Peptide Cellular Response To Hormone Stimulus Intracellular Signal Transduction Cellular Response To Stimulus Response To Stress Locomotion Positive Regulation Of Signal Transduction Response To Organonitrogen Compound System Development Chemotaxis Multicellular Organismal Development Cell Differentiation Response To Hormone Regulation Of Phosphorylation Anatomical Structure Development	Regulation Of Lateral Mesodermal Cell Fate Specification Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Lung Development Respiratory Tube Development Ventricular Zone Neuroblast Division Respiratory System Development Orbitofrontal Cortex Development Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Outer Ear Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Mesenchymal-epithelial Cell Signaling Forebrain Neuroblast Division Regulation Of Branching Involved In Salivary Gland Morphogenesis Auditory Receptor Cell Development Lung-associated Mesenchyme Development Regulation Of Cell Fate Specification Tube Development Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Paraxial Mesoderm Development Middle Ear Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Somatic Stem Cell Division Positive Regulation Of Cardiac Muscle Cell Proliferation Branching Involved In Salivary Gland Morphogenesis Auditory Receptor Cell Differentiation Regulation Of Cell Fate Commitment Cell-cell Signaling Regulation Of Gastrulation Organ Induction Hair Cell Differentiation Positive Regulation Of Heart Growth Inner Ear Receptor Cell Development Positive Regulation Of Mesenchymal Cell Proliferation Stem Cell Division Regulation Of Cardiac Muscle Cell Proliferation Salivary Gland Morphogenesis Salivary Gland Development Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Organ Growth Cell Proliferation In Forebrain Negative Regulation Of Transcription, DNA-templated Developmental Induction Regulation Of Organ Formation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Lung Alveolus Development Neuroblast Proliferation Neurological System Process
Tagcloud ?		abrogated abrogation acetic antiproliferative aromatic arteriosclerosis compete dimerization embedded f32 former heparan heparin heparinase hs hydroxyphenoxy kd microvessel mimics mitogenic nonsulfated nontoxic outgrowth polyanionic proteoglycans restenosis rg rings	clopidogrel clots corresponds dissolution elt euglobulin extrinsic fgfc1 fibrin fibrinogen fibrinogenolysis fibrinolytic fitc fluorescein hemolytic hemorrhagic isothiocyanate lysis ogen olytic pharmacodynamic pyranoindole shortened stems thromboembolism thrombolysis thrombolytic thrombus urokinase
Tagcloud (Difference) ?		abrogated abrogation acetic antiproliferative aromatic arteriosclerosis compete dimerization embedded f32 former heparan heparin heparinase hs hydroxyphenoxy kd microvessel mimics mitogenic nonsulfated nontoxic outgrowth polyanionic proteoglycans restenosis rg rings	clopidogrel clots corresponds dissolution elt euglobulin extrinsic fgfc1 fibrin fibrinogen fibrinogenolysis fibrinolytic fitc fluorescein hemolytic hemorrhagic isothiocyanate lysis ogen olytic pharmacodynamic pyranoindole shortened stems thromboembolism thrombolysis thrombolytic thrombus urokinase
Tagcloud (Intersection) ?