FGFR1 and PTK6

Number of citations of the paper that reports this interaction (PMID 22974441)
2

Data Source:
BioGRID (unspecified method)

		FGFR1	PTK6
Gene Name		fibroblast growth factor receptor 1	protein tyrosine kinase 6
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Receptor Complex	Ruffle Nucleus Nucleoplasm Cytoplasm Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding Identical Protein Binding Protein Homodimerization Activity	Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Skeletal System Development Angiogenesis Ureteric Bud Development In Utero Embryonic Development Organ Induction Neuron Migration Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Transcription, DNA-templated Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Sensory Perception Of Sound Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Ventricular Zone Neuroblast Division Embryonic Limb Morphogenesis Midbrain Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fc-epsilon Receptor Signaling Pathway Inner Ear Morphogenesis Outer Ear Morphogenesis Middle Ear Morphogenesis Chordate Embryonic Development Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Innate Immune Response Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Paraxial Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Cell Maturation Skeletal System Morphogenesis Mesenchymal Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Auditory Receptor Cell Development Branching Involved In Salivary Gland Morphogenesis Lung-associated Mesenchyme Development Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Neuron Projection Development Cell Migration Actin Cytoskeleton Organization Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Tyrosine Phosphorylation Of Stat3 Protein Tyrosine Phosphorylation Of Stat5 Protein Innate Immune Response Negative Regulation Of Growth Protein Autophosphorylation Intestinal Epithelial Cell Differentiation Negative Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Retinoic Acid
Pathways		Signaling by FGFR in disease Signaling by activated point mutants of FGFR1 Signaling by FGFR1 mutants Signaling by FGFR mutants
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		45 interactors: BNIP2 CREBBP CRK CTPS2 EPHA4 ERBB3 FDPS FGF1 FGF17 FGF18 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FLRT3 FRS2 FRS3 GRB14 GRB2 IL17RD ITK KPNB1 MMP2 NCAM1 NCK1 NCK2 NEDD4 NRP1 PIK3R1 PIK3R2 PLCG1 PTK6 RPS6KA1 RPS6KA3 RTN3 SH3BP2 SHC1 SLA SOS1 TNS2 VAV1	14 interactors: APP CCDC33 DOK1 EFHC2 EGFR ERBB3 EXOC5 FCHO1 FGFR1 KHDRBS1 KHDRBS2 REL STAP2 WASL
Entrez ID		2260	5753
HPRD ID		00634	03594
Ensembl ID		ENSG00000077782	ENSG00000101213
Uniprot IDs		P11362	Q13882
PDB IDs		1AGW 1CVS 1EVT 1FGI 1FGK 1FQ9 1XR0 2CR3 2FGI 3C4F 3DPK 3GQI 3GQL 3JS2 3KRJ 3KRL 3KXX 3KY2 3OJV 3RHX 3TT0 4F63 4F64 4F65	1RJA 2KGT
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Fc Receptor Signaling Pathway Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Immune Response Immune Response Cellular Response To Insulin Stimulus Cellular Response To Organic Substance Defense Response Cell Surface Receptor Signaling Pathway Response To Insulin Regulation Of Immune System Process Cellular Response To Peptide Hormone Stimulus Immune System Process Cellular Response To Peptide Signal Transduction Cellular Response To Organonitrogen Compound Response To Organic Substance Signaling Cell Communication Response To Peptide Hormone Response To Peptide Cellular Response To Hormone Stimulus Intracellular Signal Transduction Cellular Response To Stimulus Response To Stress Locomotion Positive Regulation Of Signal Transduction Response To Organonitrogen Compound System Development Chemotaxis Multicellular Organismal Development Cell Differentiation Response To Hormone Regulation Of Phosphorylation Anatomical Structure Development	Innate Immune Response Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Immune Response Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Enzyme Linked Receptor Protein Signaling Pathway Phosphatidylinositol-mediated Signaling Immune Response-regulating Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Axonogenesis Response To Fibroblast Growth Factor Positive Regulation Of Cellular Protein Metabolic Process Axon Development Regulation Of Peptidyl-tyrosine Phosphorylation Cell Morphogenesis Involved In Neuron Differentiation Neurotrophin TRK Receptor Signaling Pathway Chemotaxis Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Immune System Process Salivary Gland Morphogenesis Regulation Of Protein Metabolic Process Salivary Gland Development Cell Morphogenesis Involved In Differentiation Peptidyl-tyrosine Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Cell Cycle Gene Expression Exocrine System Development Positive Regulation Of Phospholipase C Activity Regulation Of Nitrogen Compound Metabolic Process Neuron Apoptotic Process Regulation Of Kinase Activity Cellular Macromolecule Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Tyrosine Kinase Activity Neuron Projection Development Macromolecule Biosynthetic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Neuron Death
Tagcloud ?		abrogated abrogation acetic antiproliferative aromatic arteriosclerosis compete dimerization embedded f32 former heparan heparin heparinase hs hydroxyphenoxy kd microvessel mimics mitogenic nonsulfated nontoxic outgrowth polyanionic proteoglycans restenosis rg rings	1r additive additively attractive benefit cancers co combined depends depleted develops dimensional directed exist her2 her3 interestingly partners powerful promoting reveals rnai simultaneously stronger successfully tumour tumourigenesis tumours xenografts
Tagcloud (Difference) ?		abrogated abrogation acetic antiproliferative aromatic arteriosclerosis compete dimerization embedded f32 former heparan heparin heparinase hs hydroxyphenoxy kd microvessel mimics mitogenic nonsulfated nontoxic outgrowth polyanionic proteoglycans restenosis rg rings	1r additive additively attractive benefit cancers co combined depends depleted develops dimensional directed exist her2 her3 interestingly partners powerful promoting reveals rnai simultaneously stronger successfully tumour tumourigenesis tumours xenografts
Tagcloud (Intersection) ?