APBB1IP and VASP

Number of citations of the paper that reports this interaction (PMID 15469846)
97

Data Source:
HPRD (in vitro, in vivo)

		APBB1IP	VASP
Gene Name		amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	vasodilator-stimulated phosphoprotein
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Lamellipodium	Cytoplasm Cytosol Plasma Membrane Tight Junction Focal Adhesion Actin Cytoskeleton Lamellipodium Membrane Filopodium Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Signal Transduction Blood Coagulation Platelet Activation	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Positive Regulation Of Actin Filament Polymerization Cell Junction Assembly T Cell Receptor Signaling Pathway Protein Homotetramerization
Pathways		p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation)	Cell junction organization TCR signaling Generation of second messenger molecules Axon guidance Signaling by Robo receptor Cell-extracellular matrix interactions Adaptive Immune System
Drugs
Diseases
GWAS		Inflammatory biomarkers ( 22228203) Response to angiotensin II receptor blocker therapy ( 22566498)
Protein-Protein Interactions		8 interactors: EVL GAS7 NDN PFN1 PRPF40A RAP1A VASP ZDHHC17	36 interactors: ABI1 ABI2 ABI3 ACTA1 ACTG1 APBB1 APBB1IP DMRTB1 DNMBP ERMAP FAT1 FGFR1OP FYB GSN LPP NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A RAPH1 SAT1 SCGB2A2 SPTA1 TES TRIM9 VCL WAS WASL WWP2 XIRP1 XPO6 ZYX
Entrez ID		54518	7408
HPRD ID		16420	03415
Ensembl ID		ENSG00000077420	ENSG00000125753
Uniprot IDs		B4E100 Q7Z5R6	P50552
PDB IDs		3ZDL	1EGX 1JNG 1USD 1USE 2PAV 2PBD 3CHW
Enriched GO Terms of Interacting Partners?		Actin Polymerization Or Depolymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Regulation Of Cellular Component Organization Cytoskeleton Organization Regulation Of Ruffle Assembly Nervous System Development Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Cytoskeleton Organization Neuron Projection Morphogenesis Actin Filament-based Process Generation Of Neurons Neurogenesis Neuron Projection Development Cell Projection Morphogenesis Positive Regulation Of Stress Fiber Assembly Actin Filament Organization Cell Part Morphogenesis Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Cellular Component Biogenesis Cell Development Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Neuron Development Regulation Of Actin Cytoskeleton Organization Regulation Of Stress Fiber Assembly Protein Homotetramerization Cell Morphogenesis Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Neuron Differentiation Cell Projection Organization Regulation Of Cell Projection Organization Locomotion Anatomical Structure Morphogenesis Regulation Of Cytoskeleton Organization Protein Tetramerization Neural Tube Closure Axonogenesis System Development Regulation Of Cell Projection Assembly Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Neural Tube Formation Response To Growth Factor	Actin Cytoskeleton Organization Actin Filament-based Process Cytoskeleton Organization Actin Filament Organization Movement Of Cell Or Subcellular Component Response To Wounding Organelle Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin Polymerization Or Depolymerization Blood Coagulation Positive Regulation Of Actin Nucleation Wound Healing Hemostasis Platelet Activation Positive Regulation Of Cytoskeleton Organization Anatomical Structure Morphogenesis Regulation Of Actin Cytoskeleton Organization Cell Development Locomotion Negative Regulation Of Protein Complex Assembly Regulation Of Body Fluid Levels Regulation Of Actin Filament-based Process Negative Regulation Of Actin Filament Polymerization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cell Projection Organization Regulation Of Actin Nucleation Regulation Of Cytoskeleton Organization Negative Regulation Of Protein Polymerization Regulation Of Cellular Component Organization Regulation Of Cellular Process Positive Regulation Of ATPase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Neuron Projection Development Actomyosin Structure Organization Cell Projection Morphogenesis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Regulation Of ATPase Activity Positive Regulation Of Immune System Process Regulation Of Organelle Organization Anatomical Structure Development Fc Receptor Signaling Pathway Cell Activation Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Neuron Development Regulation Of Immune System Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Biogenesis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Tagcloud ?			abm acta cardinal colocalize concentrates concentrating factories fppppx gppppp immunolocalization listeria microinjection motile motility perinuclear phosphoprotein profilin rear redistributed rocket shigella tails underscore vaccinia vasodilator vinculin virions xppppp zyxin
Tagcloud (Difference) ?			abm acta cardinal colocalize concentrates concentrating factories fppppx gppppp immunolocalization listeria microinjection motile motility perinuclear phosphoprotein profilin rear redistributed rocket shigella tails underscore vaccinia vasodilator vinculin virions xppppp zyxin
Tagcloud (Intersection) ?