CD68 and CLEC2D

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CD68	CLEC2D
Name		CD68 molecule	C-type lectin domain family 2 member D
Structure		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Late Endosome Membrane Azurophil Granule Membrane	Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Carbohydrate Binding
	Biological Process	Inflammatory Response To Antigenic Stimulus Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Cellular Response To Nutrient Levels Autocrine Signaling Response To Ethanol Cellular Response To Lipopolysaccharide Establishment Of Protein Localization To Organelle Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus	Cell Surface Receptor Signaling Pathway
Pathways		Neutrophil degranulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
GWAS		Brain morphology (MOSTest) ( 32665545 ) Heel bone mineral density ( 28869591 ) IgA levels ( 28628107 ) Metabolic syndrome ( 31589552 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Refractive error ( 32231278 )	Autoimmune thyroid disease ( 32581359 ) HDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535 ) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Multiple sclerosis ( 31604244 )
Interacting Genes		13 interacting genes: ADRB2 AGR2 AQP6 CFTR CLEC2D KTN1 MAL2 MUC1 PLEKHB2 RALGDS SGTB TMEM179B TOMM6	33 interacting genes: ADIPOQ ATP6V0C B3GALT5 BRICD5 CD68 CLDN19 CLDN2 CLEC2A CLRN2 CXCL9 DEFB121 ENTPD8 ERMP1 FAM3C FNDC9 GPR42 IL1RL1 KLRB1 KLRC1 LEPROTL1 NKG7 PLLP PLN PLP1 RPRM SEC22A SHMT2 SYT15 SYT15B TM4SF18 TMEM190 TMEM80 TSPAN4
Entrez ID		968	29121
HPRD ID		01093	16134
Ensembl ID		ENSG00000129226	ENSG00000069493
Uniprot IDs		P34810	Q9UHP7 W8JXM2
PDB IDs		Not available	4QKG 4QKH 4QKI 4QKJ 4WCO 5MGT
GO Terms Enriched among Interactors		Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Apical Plasma Membrane Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Mini Excitatory Postsynaptic Potential Nitrate Transmembrane Transporter Activity Fluid Transport Water Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Clathrin-coated Endocytic Vesicle Membrane Beta2-adrenergic Receptor Activity Membrane PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Positive Regulation Of Anion Channel Activity TRC Complex Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Norepinephrine Binding Chloride Transmembrane Transport Odontogenesis Chloride Transport Protein-folding Chaperone Binding Positive Regulation Of Enamel Mineralization Recycling Endosome Membrane Positive Regulation Of Monoatomic Anion Transport Lung Goblet Cell Differentiation Positive Regulation Of PERK-mediated Unfolded Protein Response	Membrane Paracellular Transport Paracellular Tight Junction Channel Activity Defense Response Structural Constituent Of Myelin Sheath