CD68 and TMEM179B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD68	TMEM179B
Description		CD68 molecule	transmembrane protein 179B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Late Endosome Membrane Azurophil Granule Membrane	Nucleolus Plasma Membrane Membrane Nuclear Speck Secretory Granule Membrane Azurophil Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Inflammatory Response To Antigenic Stimulus Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Cellular Response To Nutrient Levels Autocrine Signaling Response To Ethanol Cellular Response To Lipopolysaccharide Establishment Of Protein Localization To Organelle Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Pathways		Neutrophil degranulation	Neutrophil degranulation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 28869591) IgA levels ( 28628107) Metabolic syndrome ( 31589552) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: ADRB2 AGR2 AQP6 CFTR CLEC2D KTN1 MAL2 MUC1 PLEKHB2 RALGDS SGTB TMEM179B TOMM6	47 interacting genes: ADIPOQ BTN2A2 C1QL4 C2CD2L C3orf52 CCDC167 CCL3L3 CCL4 CCL4L2 CD68 CLCA4 CLCN7 CLDN1 CLDN6 CTXN3 CYB561 DERL3 ERGIC3 FAM163A FATE1 FCER1G FXYD3 GALNT15 GKN1 GPR151 GUCA2A IGFBP5 KRTAP12-2 KTN1 LRP10 LYG1 MARCHF2 MFSD6 PLN SERP2 SLC1A1 SLC22A1 SLC52A1 SLC61A1 STX8 TM4SF19 TMEM14A TMEM236 TMEM237 TMEM242 TMEM47 TRARG1
Entrez ID		968	374395
HPRD ID		01093	14186
Ensembl ID		ENSG00000129226	ENSG00000185475
Uniprot IDs		P34810	G3V185 Q7Z7N9
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Apical Plasma Membrane Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Mini Excitatory Postsynaptic Potential Nitrate Transmembrane Transporter Activity Fluid Transport Water Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Clathrin-coated Endocytic Vesicle Membrane Beta2-adrenergic Receptor Activity Membrane PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Positive Regulation Of Anion Channel Activity TRC Complex Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Norepinephrine Binding Chloride Transmembrane Transport Odontogenesis Chloride Transport Protein-folding Chaperone Binding Positive Regulation Of Enamel Mineralization Recycling Endosome Membrane Positive Regulation Of Monoatomic Anion Transport Lung Goblet Cell Differentiation Positive Regulation Of PERK-mediated Unfolded Protein Response	Membrane Inorganic Anion Transport
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