CD68 and PLEKHB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD68	PLEKHB2
Description		CD68 molecule	pleckstrin homology domain containing B2
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Late Endosome Membrane Azurophil Granule Membrane	Endosome Membrane Recycling Endosome Membrane
	Molecular Function	Protein Binding	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding
	Biological Process	Inflammatory Response To Antigenic Stimulus Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Cellular Response To Nutrient Levels Autocrine Signaling Response To Ethanol Cellular Response To Lipopolysaccharide Establishment Of Protein Localization To Organelle Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus	Regulation Of Cell Differentiation
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 28869591) IgA levels ( 28628107) Metabolic syndrome ( 31589552) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278)
Interacting Genes		13 interacting genes: ADRB2 AGR2 AQP6 CFTR CLEC2D KTN1 MAL2 MUC1 PLEKHB2 RALGDS SGTB TMEM179B TOMM6	51 interacting genes: ATF7IP BHLHE40 C1orf94 CD68 CDA CFTR CLDN19 DAZAP2 DCUN1D1 EMP1 EMP3 EPN1 EPN2 FAM168A FOXD4L3 GGA3 GJB2 GLIS2 HEY1 HEYL HGS HIVEP1 MAP3K1 MED25 MTURN NTAQ1 OTUB2 PIP4P1 PITX1 POGZ PROP1 RHBDD1 RPS27A RUNX1 SFT2D1 SNRPB STAM2 SYNGR1 TAX1BP1 TRARG1 UBA52 UBAC1 UBAP2 UBASH3A UBB UBC UBQLN2 UBXN6 UPF1 YOD1 ZFAND2A
Entrez ID		968	55041
HPRD ID		01093	15144
Ensembl ID		ENSG00000129226	ENSG00000115762
Uniprot IDs		P34810	A0A0A0MSE9 A0A0A0MSI4 B4DJB7 Q96CS7
PDB IDs			3AJ4 3VIA
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Apical Plasma Membrane Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Mini Excitatory Postsynaptic Potential Nitrate Transmembrane Transporter Activity Fluid Transport Water Transport Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Clathrin-coated Endocytic Vesicle Membrane Beta2-adrenergic Receptor Activity Membrane PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Positive Regulation Of Anion Channel Activity TRC Complex Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Norepinephrine Binding Chloride Transmembrane Transport Odontogenesis Chloride Transport Protein-folding Chaperone Binding Positive Regulation Of Enamel Mineralization Recycling Endosome Membrane Positive Regulation Of Monoatomic Anion Transport Lung Goblet Cell Differentiation Positive Regulation Of PERK-mediated Unfolded Protein Response	Protein Tag Activity Endosome Membrane ESCRT-0 Complex Positive Regulation Of Macromolecule Metabolic Process Cytoplasm DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Macromolecule Catabolic Process Endocytic Vesicle Membrane Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Autophagy Endosome Transport Via Multivesicular Body Sorting Pathway Ubiquitin Binding Clathrin Vesicle Coat ERAD Pathway Early Endosome Membrane Bleb Assembly Multivesicular Body Sorting Pathway Endosome Protein K11-linked Deubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
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