RAP2B and RAB40B

Number of citations of the paper that reports this interaction (PubMedID 35293963)
87

Data Source:
BioGRID (pull down)

		RAP2B	RAB40B
Description		RAP2B, member of RAS oncogene family	RAB40B, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Bicellular Tight Junction Endomembrane System Membrane Cytoplasmic Vesicle Membrane Specific Granule Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane Bounding Membrane Of Organelle	Ruffle Nuclear Envelope Cytoplasm Endosome Cytosol Plasma Membrane Synaptic Vesicle Membrane Lamellipodium Lamellipodium Membrane Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Signal Transduction Platelet Activation Negative Regulation Of Cell Migration Rap Protein Signal Transduction Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier	Exocytosis Protein Ubiquitination Positive Regulation Of Cell Migration Negative Regulation Of Actin Filament Bundle Assembly Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Lamellipodium Organization Cellular Detoxification
Pathways		Neutrophil degranulation	RAB geranylgeranylation
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 30361487) Chronotype ( 30696823) Cutaneous melanoma or hair colour ( 32341527) Metabolite levels ( 23823483) PR interval ( 32439900) Serum sulfate level ( 27412988)	Colorectal cancer or advanced adenoma ( 30510241)
Interacting Genes		10 interacting genes: CAMK2B PDE6D RAB40B RALGDS RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF5 RASSF5 RUNDC3A	10 interacting genes: ANKRD27 APP CRYAA EFEMP2 FHIT FHL3 RAP2A RAP2B RAP2C WFDC1
Entrez ID		5912	10966
HPRD ID		01548	11472
Ensembl ID		ENSG00000181467	ENSG00000141542
Uniprot IDs		P61225	Q12829
PDB IDs		1N4P 1N4Q 1N4R
Enriched GO Terms of Interacting Partners?		Guanyl-nucleotide Exchange Factor Activity Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction GTPase Regulator Activity Signal Transduction Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Intracellular Signal Transduction CAMP Binding Positive Regulation Of Neuron Projection Development Intracellular Signaling Cassette Neurotrophin Signaling Pathway Establishment Of Endothelial Barrier Nervous System Development Endothelial Cell Development Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Regulation Of Neuron Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Response To CAMP Regulation Of Cell Projection Organization CAAX-box Protein Maturation Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell Projection Organization Response To CAMP Positive Regulation Of GTPase Activity Response To Antipsychotic Drug Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Regulation Of Dendrite Development Positive Regulation Of CAMP-dependent Protein Kinase Activity Beta-1 Adrenergic Receptor Binding Regulation Of Neuron Projection Development Positive Regulation Of Hydrolase Activity Myosin Filament Assembly Brain-derived Neurotrophic Factor Receptor Signaling Pathway CAMP-mediated Signaling Negative Regulation Of Melanin Biosynthetic Process Positive Regulation Of Dendritic Cell Apoptotic Process Calcium- And Calmodulin-dependent Protein Kinase Complex System Development Modulation Of Chemical Synaptic Transmission Regulation Of GTPase Activity Epithelial Cell Development Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Microvillus Assembly Response To Purine-containing Compound Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Synapse Structural Plasticity CAMP-dependent Protein Kinase Regulator Activity	Rap Protein Signal Transduction Bounding Membrane Of Organelle Recycling Endosome Cytoplasmic Vesicle Membrane GDP Binding Endomembrane System G Protein Activity Recycling Endosome Membrane Endosome Establishment Of Endothelial Intestinal Barrier Regulation Of Protein Tyrosine Kinase Activity Cell-cell Contact Zone Establishment Of Endothelial Barrier Endothelial Cell Development Amyloid-beta Complex Growth Cone Lamellipodium Synaptic Membrane Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Adenylylsulfatase Activity Adenylylsulfate-ammonia Adenylyltransferase Activity Diadenosine Triphosphate Catabolic Process Regulation Of Dendrite Morphogenesis Small GTPase-mediated Signal Transduction Tertiary Granule Membrane Positive Regulation Of Smooth Muscle Cell-matrix Adhesion GTPase Activity Negative Regulation Of Cell Migration Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization Intracellular Signaling Cassette Cell Development Lipoprotein Particle Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of Protein Import GTP Binding Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Negative Regulation Of SNARE Complex Assembly PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Cell Migration Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway
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