RAP2B and RAPGEF2

Number of citations of the paper that reports this interaction (PMID 10934204)
24

Data Source:
HPRD (in vivo, in vitro)

		RAP2B	RAPGEF2
Gene Name		RAP2B, member of RAS oncogene family	Rap guanine nucleotide exchange factor (GEF) 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Tight Junction Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Membrane Extracellular Vesicular Exosome	Cytoplasm Late Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Tight Junction Membrane Apical Plasma Membrane Endocytic Vesicle Neuron Projection Neuronal Cell Body Protein Complex Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	GTP Binding GDP Binding Protein Domain Specific Binding	Signal Transducer Activity Ras Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Rap Guanyl-nucleotide Exchange Factor Activity Protein Kinase Binding Diacylglycerol Binding PDZ Domain Binding CAMP Binding CGMP Binding Beta-1 Adrenergic Receptor Binding Rap GTPase Activator Activity WW Domain Binding Phosphatidic Acid Binding
	Biological Process	Signal Transduction Microvillus Assembly Platelet Activation Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier	MAPK Cascade Blood Vessel Development Neuron Migration G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Proliferation Positive Regulation Of Neuron Projection Development CAMP-mediated Signaling Ventricular System Development Forebrain Neuron Development Microvillus Assembly Neuron Projection Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Positive Regulation Of Ras GTPase Activity Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Intracellular Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Protein Kinase Activity Negative Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To CGMP Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Vasculogenesis Positive Regulation Of Neuron Migration
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CAMK2B PDE6D RALA RALGDS RAPGEF2 RAPGEF5 RASSF5 RUNDC3A	12 interactors: ATP8 CTNNB1 HSPA1A KIF5A KIF5B MAGI2 MOB4 NEDD4 RALGDS RAP1A RAP2B SPP1
Entrez ID		5912	9693
HPRD ID		01548	19358
Ensembl ID			ENSG00000109756
Uniprot IDs		P61225	Q9Y4G8
PDB IDs
Enriched GO Terms of Interacting Partners?		Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Positive Regulation Of Rap GTPase Activity Regulation Of Rap GTPase Activity Regulation Of Rap Protein Signal Transduction Ras Protein Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Cell Projection Organization Signal Transduction Response To Stimulus Regulation Of Dendrite Morphogenesis Signaling Cell Communication Inhibitory G-protein Coupled Receptor Phosphorylation Regulation Of Catalytic Activity Regulation Of Cell Projection Organization Regulation Of Dendrite Development Negative Regulation Of Melanin Biosynthetic Process Activation Of Meiosis Involved In Egg Activation Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Response To Growth Factor Positive Regulation Of Catalytic Activity Brain-derived Neurotrophic Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Raft Localization Activation Of Meiosis Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process Regulation Of Synaptic Plasticity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of GTPase Activity Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Establishment Of Endothelial Intestinal Barrier Cellular Response To CGMP Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Metabolic Process Positive Regulation Of Neuron Projection Development Response To CGMP Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Dendrite Morphogenesis Rap Protein Signal Transduction Regulation Of Skeletal Muscle Adaptation Positive Regulation Of Guanylate Cyclase Activity Regulation Of Synapse Structural Plasticity Positive Regulation Of Hydrolase Activity Positive Regulation Of Vasculogenesis	Generation Of Neurons Neurogenesis Rap Protein Signal Transduction Regulation Of Cellular Component Organization Regulation Of Neurogenesis Locomotion Nerve Growth Factor Signaling Pathway Regulation Of Neuron Projection Development Regulation Of Cell Development Nervous System Development Regulation Of Cell Differentiation Establishment Of Endothelial Barrier Response To Organic Substance Regulation Of Cell Projection Organization Cellular Response To Nerve Growth Factor Stimulus Regulation Of Neuron Differentiation Cell Development Epithelial Cell Development Cellular Response To Growth Factor Stimulus Ras Protein Signal Transduction Neurotrophin Signaling Pathway Response To Growth Factor Negative Regulation Of Signaling Establishment Of Localization In Cell Endothelial Cell Development Regulation Of Signaling Cell Activation Regulation Of Potassium Ion Transport Cell Differentiation Homotypic Cell-cell Adhesion Response To Stress Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Localization Intracellular Transport Intracellular Steroid Hormone Receptor Signaling Pathway Endothelial Cell Differentiation Positive Regulation Of Cell Differentiation Response To Stimulus Transport Endothelium Development Positive Regulation Of Neurogenesis Tissue Development Negative Regulation Of Mitotic Cell Cycle, Embryonic Cellular Heat Acclimation Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Stress Granule Disassembly Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Tagcloud ?		activates anchorage arrest balance binds counters damage decision depends evokes fate genomic integrative interference mediate oncogene overexpressed p53 player possibility pro programs raise reveals sensitize sensitizes ultimate upon weak	adapter aneuploidy betatrcp2 biochemistry comprehensively computation cul1 destabilized fbxw11 guanine identifier immunopurified instrumentation ligases multinucleation necessitates pac polyubiquitylated processivity proteomexchange proteomics putatively pxd001062 rap1 scf skp1 ubiquitylated ubiquitylation
Tagcloud (Difference) ?		activates anchorage arrest balance binds counters damage decision depends evokes fate genomic integrative interference mediate oncogene overexpressed p53 player possibility pro programs raise reveals sensitize sensitizes ultimate upon weak	adapter aneuploidy betatrcp2 biochemistry comprehensively computation cul1 destabilized fbxw11 guanine identifier immunopurified instrumentation ligases multinucleation necessitates pac polyubiquitylated processivity proteomexchange proteomics putatively pxd001062 rap1 scf skp1 ubiquitylated ubiquitylation
Tagcloud (Intersection) ?