RAP2B and RAPGEF5

Number of citations of the paper that reports this interaction (PMID 10934204)
24

Data Source:
HPRD (in vitro)

		RAP2B	RAPGEF5
Gene Name		RAP2B, member of RAS oncogene family	Rap guanine nucleotide exchange factor (GEF) 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Tight Junction Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Membrane Extracellular Vesicular Exosome	Nucleus
	Molecular Function	GTP Binding GDP Binding Protein Domain Specific Binding	Ras Guanyl-nucleotide Exchange Factor Activity Rap Guanyl-nucleotide Exchange Factor Activity GTP-dependent Protein Binding
	Biological Process	Signal Transduction Microvillus Assembly Platelet Activation Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier	Small GTPase Mediated Signal Transduction Nervous System Development Positive Regulation Of Ras GTPase Activity Positive Regulation Of Rap GTPase Activity
Pathways
Drugs
Diseases
GWAS			Dialysis-related mortality ( 21546767) Thyroid stimulating hormone ( 17903292)
Protein-Protein Interactions		8 interactors: CAMK2B PDE6D RALA RALGDS RAPGEF2 RAPGEF5 RASSF5 RUNDC3A	7 interactors: MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1
Entrez ID		5912	9771
HPRD ID		01548	15208
Ensembl ID			ENSG00000136237
Uniprot IDs		P61225	A8MQ07 Q5JPD2 Q92565
PDB IDs			1WGY
Enriched GO Terms of Interacting Partners?		Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Positive Regulation Of Rap GTPase Activity Regulation Of Rap GTPase Activity Regulation Of Rap Protein Signal Transduction Ras Protein Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Cell Projection Organization Signal Transduction Response To Stimulus Regulation Of Dendrite Morphogenesis Signaling Cell Communication Inhibitory G-protein Coupled Receptor Phosphorylation Regulation Of Catalytic Activity Regulation Of Cell Projection Organization Regulation Of Dendrite Development Negative Regulation Of Melanin Biosynthetic Process Activation Of Meiosis Involved In Egg Activation Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Response To Growth Factor Positive Regulation Of Catalytic Activity Brain-derived Neurotrophic Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Raft Localization Activation Of Meiosis Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process Regulation Of Synaptic Plasticity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of GTPase Activity Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Establishment Of Endothelial Intestinal Barrier Cellular Response To CGMP Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Metabolic Process Positive Regulation Of Neuron Projection Development Response To CGMP Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Dendrite Morphogenesis Rap Protein Signal Transduction Regulation Of Skeletal Muscle Adaptation Positive Regulation Of Guanylate Cyclase Activity Regulation Of Synapse Structural Plasticity Positive Regulation Of Hydrolase Activity Positive Regulation Of Vasculogenesis	Rap Protein Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Autophosphorylation Regulation Of Protein Autophosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Platelet Activation Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of Protein Phosphorylation Negative Regulation Of Cellular Component Movement Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Locomotion Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Vasculogenesis Regulation Of Neuron Projection Development Nerve Growth Factor Signaling Pathway Blood Coagulation Hemostasis Microvillus Assembly Negative Regulation Of Synaptic Vesicle Exocytosis Microvillus Organization Regulation Of Vasculogenesis Positive Regulation Of Rap GTPase Activity Regulation Of Cell Projection Organization Negative Regulation Of Neurotransmitter Secretion Regulation Of Rap GTPase Activity Negative Regulation Of Neurotransmitter Transport Regulation Of Cellular Protein Metabolic Process Regulation Of Neuron Differentiation Regulation Of Rap Protein Signal Transduction Cellular Response To Nerve Growth Factor Stimulus Regulation Of Body Fluid Levels Regulation Of Cell Migration Establishment Of Endothelial Barrier Wound Healing Actin Cytoskeleton Organization Regulation Of MAPK Cascade Regulation Of Cell Motility Multicellular Organismal Development Regulation Of Protein Metabolic Process Regulation Of Synaptic Vesicle Exocytosis Actin Filament-based Process Regulation Of Locomotion Cell Activation
Tagcloud ?		activates anchorage arrest balance binds counters damage decision depends evokes fate genomic integrative interference mediate oncogene overexpressed p53 player possibility pro programs raise reveals sensitize sensitizes ultimate upon weak
Tagcloud (Difference) ?		activates anchorage arrest balance binds counters damage decision depends evokes fate genomic integrative interference mediate oncogene overexpressed p53 player possibility pro programs raise reveals sensitize sensitizes ultimate upon weak
Tagcloud (Intersection) ?