RAP2B and CAMK2B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		RAP2B	CAMK2B
Description		RAP2B, member of RAS oncogene family	calcium/calmodulin dependent protein kinase II beta
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GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Bicellular Tight Junction Endomembrane System Membrane Cytoplasmic Vesicle Membrane Specific Granule Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane Bounding Membrane Of Organelle	Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection Synapse
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding	Nucleotide Binding Actin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	Signal Transduction Platelet Activation Negative Regulation Of Cell Migration Rap Protein Signal Transduction Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier	Protein Phosphorylation Signal Transduction Nervous System Development Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Cell Differentiation Protein Autophosphorylation Regulation Of Neuronal Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Structural Plasticity Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Regulation Of Protein Localization To Plasma Membrane Regulation Of Neuron Migration
Pathways		Neutrophil degranulation	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile Fostamatinib
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 30361487) Chronotype ( 30696823) Cutaneous melanoma or hair colour ( 32341527) Metabolite levels ( 23823483) PR interval ( 32439900) Serum sulfate level ( 27412988)	Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Fasting glucose ( 34059833) Intracranial aneurysm ( 29531279) Metabolic syndrome ( 22399527) Osteoarthritis (hip) ( 23989986) Systolic blood pressure ( 30578418) Triglyceride levels ( 32203549) Two-hour glucose ( 34059833)
Interacting Genes		10 interacting genes: CAMK2B PDE6D RAB40B RALGDS RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF5 RASSF5 RUNDC3A	58 interacting genes: ACOT7 ACTN4 ARSA ATXN1 CAMK2D CAMK2N2 CCM2L CDC37 COL4A3 DUS1L ETS1 FAM171A2 FMR1 FXR1 FXR2 GAPDH GRIN2A GRIN2B ITPKA KRT86 KRTAP1-1 KRTAP10-11 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-2 KRTAP6-3 MAD2L2 MED18 MEOX2 MGAT5B MORF4L1 MORF4L2 MRPL11 MVP NCOR2 PHKB PLCB3 PNKP POLR3C POP5 RAP2B RBFOX2 RBPMS RNF4 RPL11 RXRG SEMA4G SHANK3 SMYD3 SPRYD7 THRB TNPO2 TNPO3 TTC5 YWHAB ZBTB32 ZMYM5
Entrez ID		5912	816
HPRD ID		01548	12127
Ensembl ID		ENSG00000181467	ENSG00000058404
Uniprot IDs		P61225	A4D2J9 B7Z1Z6 Q13554
PDB IDs		1N4P 1N4Q 1N4R	3BHH 7URW 7URY 7URZ
Enriched GO Terms of Interacting Partners?		Guanyl-nucleotide Exchange Factor Activity Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction GTPase Regulator Activity Signal Transduction Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Intracellular Signal Transduction CAMP Binding Positive Regulation Of Neuron Projection Development Intracellular Signaling Cassette Neurotrophin Signaling Pathway Establishment Of Endothelial Barrier Nervous System Development Endothelial Cell Development Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Regulation Of Neuron Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Response To CAMP Regulation Of Cell Projection Organization CAAX-box Protein Maturation Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell Projection Organization Response To CAMP Positive Regulation Of GTPase Activity Response To Antipsychotic Drug Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Regulation Of Dendrite Development Positive Regulation Of CAMP-dependent Protein Kinase Activity Beta-1 Adrenergic Receptor Binding Regulation Of Neuron Projection Development Positive Regulation Of Hydrolase Activity Myosin Filament Assembly Brain-derived Neurotrophic Factor Receptor Signaling Pathway CAMP-mediated Signaling Negative Regulation Of Melanin Biosynthetic Process Positive Regulation Of Dendritic Cell Apoptotic Process Calcium- And Calmodulin-dependent Protein Kinase Complex System Development Modulation Of Chemical Synaptic Transmission Regulation Of GTPase Activity Epithelial Cell Development Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Microvillus Assembly Response To Purine-containing Compound Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Synapse Structural Plasticity CAMP-dependent Protein Kinase Regulator Activity	Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Intermediate Filament Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Translation Regulator Activity Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process RNA Strand Annealing Activity Positive Regulation Of Neurogenesis Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Synaptic Transmission Neuron Projection Dendritic Spine Regulation Of RNA Metabolic Process Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Membraneless Organelle NMDA Glutamate Receptor Activity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Presynaptic Modulation Of Chemical Synaptic Transmission Cytoplasmic Stress Granule Positive Regulation Of Dendritic Spine Development Poly(G) Binding Positive Regulation Of Nervous System Development Positive Regulation Of Double-strand Break Repair Nuclear Receptor-mediated Signaling Pathway NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Metabolic Process Postsynaptic Actin Cytoskeleton Excitatory Chemical Synaptic Transmission Regulation Of Macromolecule Metabolic Process Molecular Condensate Scaffold Activity Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Ubiquitin-protein Transferase Activity Protein Binding Glutamate Receptor Signaling Pathway Regulation Of Nervous System Process
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