APBB3 and RAB4A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		APBB3	RAB4A
Gene Name		amyloid beta (A4) precursor protein-binding, family B, member 3	RAB4A, member RAS oncogene family
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Actin Cytoskeleton	Endosome Membrane Vesicle Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Beta-amyloid Binding Protein Binding Transcription Factor Binding	GTPase Activity Protein Binding GTP Binding Protein Transporter Activity GDP Binding
	Biological Process	Regulation Of Transcription, DNA-templated	Intracellular Protein Transport Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Membrane Organization
Pathways			Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS			Aging ( 22773346)
Protein-Protein Interactions		6 interactors: APLP1 APLP2 APP EGFR ERBB2 RAB4A	31 interactors: ACTB APBB3 CD2AP CDK1 CHM DYNC1LI1 DYNLL1 EXOC5 GDI2 GRIPAP1 HACE1 IDH3A KIF3B MAPK3 PIN1 PRKCI PTTG1IP RAB11FIP1 RAB7A RABAC1 RABEP1 RABEP2 RABGAP1 RABGEF1 RBSN RUFY1 SOD2 STX4 TP53 VPS52 ZNF830
Entrez ID		10307	5867
HPRD ID		04089	01541
Ensembl ID		ENSG00000113108	ENSG00000168118
Uniprot IDs		O95704 Q59EH2 Q96DX9	P20338
PDB IDs		2DYQ 2YSC	1YU9 1Z0K 2BMD 2BME
Enriched GO Terms of Interacting Partners?		Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Development Regulation Of ERBB Signaling Pathway Forebrain Development Regulation Of Phosphorus Metabolic Process Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Kinase Activity Brain Development Regulation Of Kinase Activity Head Development MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Cellular Protein Metabolic Process Mating Behavior Regulation Of Translation RNA Polyadenylation Regulation Of Protein Metabolic Process Nervous System Development Regulation Of Protein Phosphorylation Neuromuscular Junction Development Mating Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Signal Transduction Regulation Of Phosphorylation Posttranscriptional Regulation Of Gene Expression Metal Ion Homeostasis Neuromuscular Process Controlling Balance MRNA 3'-end Processing Regulation Of Cellular Ketone Metabolic Process Organ Development Signaling Axonogenesis Cell Communication Cell Surface Receptor Signaling Pathway Feeding Behavior Ion Homeostasis Alkanesulfonate Metabolic Process Axon Development Cell Morphogenesis Involved In Neuron Differentiation RNA 3'-end Processing Behavior Chemotaxis Cholesterol Metabolic Process	Membrane Organization Protein Transport Establishment Of Protein Localization Protein Localization Vesicle-mediated Transport Cell Cycle Transport Regulation Of Catalytic Activity Regulation Of Cellular Localization Organelle Organization Ras Protein Signal Transduction Positive Regulation Of Catalytic Activity Protein Targeting Endocytosis Mitotic Cell Cycle Process Response To Wounding Membrane Fusion Positive Regulation Of GTPase Activity Mitotic Cell Cycle Regulation Of GTPase Activity Regulation Of Protein Localization Mitotic Nuclear Division Intracellular Transport Regulation Of Cellular Component Organization Cellular Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Intracellular Protein Transport Organelle Fusion Regulation Of Mitotic Cell Cycle Regulation Of Establishment Of Protein Localization Blood Coagulation Cellular Protein Localization Hemostasis Regulation Of Intracellular Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Hydrolase Activity Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Membrane Docking Mitotic DNA Damage Checkpoint Positive Regulation Of Transport Regulation Of Signal Transduction Intracellular Signal Transduction Mitotic DNA Integrity Checkpoint Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Component Assembly Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Metabolic Process
Tagcloud ?			abnormally accessing anova cascades ckit decoupled dex dexamethasone ery erys erythroblast erythroblasts erythropoiesis escape expansion fdr gata1 gpr56 il3 pdgfrbeta polycythemia polycythemic pv repertoire scf tal1 tgfbeta tightly vera
Tagcloud (Difference) ?			abnormally accessing anova cascades ckit decoupled dex dexamethasone ery erys erythroblast erythroblasts erythropoiesis escape expansion fdr gata1 gpr56 il3 pdgfrbeta polycythemia polycythemic pv repertoire scf tal1 tgfbeta tightly vera
Tagcloud (Intersection) ?