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QARS1 and H2AX
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
QARS1
H2AX
Description
glutaminyl-tRNA synthetase 1
H2A.X variant histone
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrial Matrix
Cytosol
Aminoacyl-tRNA Synthetase Multienzyme Complex
Protein-containing Complex
Chromosome, Telomeric Region
Chromatin
Nucleosome
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Centrosome
Nuclear Speck
Site Of Double-strand Break
Extracellular Exosome
Site Of DNA Damage
Molecular Function
Nucleotide Binding
Aminoacyl-tRNA Ligase Activity
Glutamine-tRNA Ligase Activity
Protein Kinase Inhibitor Activity
Protein Binding
ATP Binding
Ligase Activity
Protein Kinase Binding
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Structural Constituent Of Chromatin
Histone Binding
Protein Heterodimerization Activity
Chromatin-protein Adaptor Activity
Biological Process
Translation
TRNA Aminoacylation For Protein Translation
Glutaminyl-tRNA Aminoacylation
Brain Development
Negative Regulation Of Stress-activated MAPK Cascade
TRNA Aminoacylation
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Apoptotic Signaling Pathway
DNA Damage Checkpoint Signaling
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
DNA Recombination
Nucleosome Assembly
DNA Damage Response
Spermatogenesis
Response To Ionizing Radiation
Heterochromatin Formation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Protein K63-linked Ubiquitination
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Protein Localization To Site Of Double-strand Break
Pathways
Selenoamino acid metabolism
Cytosolic tRNA aminoacylation
Mitochondrial tRNA aminoacylation
Transcriptional and post-translational regulation of MITF-M expression and activity
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
Assembly of the ORC complex at the origin of replication
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Amyloid fiber formation
Chromatin modifications during the maternal to zygotic transition (MZT)
Replacement of protamines by nucleosomes in the male pronucleus
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS
Interacting Genes
158 interacting genes:
ACTN2
ANXA7
APP
ASL
B9D2
BIRC7
BTG3
CCDC33
CDK4
CDKN1A
CLTC
COG6
CPNE3
CTBP2
DISC1
DNM2
DPPA4
DTX2
DUSP11
EDC3
EFHC2
ESS2
FAM118B
FAM161A
FAM83A
GADD45A
GPBP1
GSK3B
GSTZ1
H2AX
HES7
HMG20A
HOXA1
IK
IKZF1
IRF1
KCNE3
KLC3
KRT36
LAMTOR3
LGALS9B
LGALS9C
LNX1
LZTS1
LZTS2
MAP3K5
MCCD1
MESD
MID2
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR155
MIR15A
MIR15B
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7G
MIRLET7I
NAB2
NEBL
NFKBID
NLGN3
NOXA1
PICK1
PIK3R3
PIN1
PRDM6
PRRC2A
PTPN21
RARS1
RBFOX2
REL
RNF10
RNF11
SAXO4
SF3B4
SHLD1
SLA
SMAD9
SMN1
SNCA
SORBS3
SP7
SPATC1L
SPDYE4
SPRED2
STK3
TADA2A
TCF12
TGM7
TK1
TLE5
TRAF2
TRAF4
TRIM27
TRIM35
TRIP13
TSC22D1
TTR
USHBP1
VPS37B
XIAP
ZMYND12
47 interacting genes:
A2M
ACTB
ALG9
ATM
ATR
BAZ1B
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
CTBP1
DDX21
EYA1
GRB2
HDAC6
HUWE1
KAT5
MAPK8
MASP1
MDC1
MRE11
MUC1
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PRKDC
PTEN
PTPA
QARS1
RNF8
RPS6KA3
SMARCA4
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TP53BP1
TRAF6
TSSK6
WRN
Entrez ID
5859
3014
HPRD ID
07223
03465
Ensembl ID
ENSG00000172053
ENSG00000188486
Uniprot IDs
B7Z840
P47897
P16104
PDB IDs
4R3Z
4YE6
4YE8
4YE9
1YDP
2AZM
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
6K1I
6K1J
6K1K
6ZWK
7YQK
Enriched GO Terms of Interacting Partners
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RISC Complex
MiRNA-mediated Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Post-transcriptional Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Regulatory NcRNA-mediated Gene Silencing
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Gene Expression
MiRNA-mediated Gene Silencing By Inhibition Of Translation
MRNA 3'-UTR Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
MiRNA-mediated Gene Silencing By MRNA Destabilization
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Extracellular Vesicle
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cytokine Production
MRNA Destabilization
RNA Destabilization
Negative Regulation Of Translation
Positive Regulation Of MRNA Catabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Multicellular Organismal Process
Negative Regulation Of Vascular Endothelial Growth Factor Production
Negative Regulation Of Angiogenesis
Negative Regulation Of Vasculature Development
Regulation Of Metabolic Process
Positive Regulation Of MRNA Metabolic Process
Negative Regulation Of Cell Motility
Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Cell Migration
Negative Regulation Of Locomotion
Regulation Of MRNA Stability
Negative Regulation Of Developmental Process
Regulation Of Angiogenesis
Regulation Of RNA Stability
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Vasculature Development
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Protein Metabolic Process
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Translation
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Endothelial Cell Migration
Regulation Of Cytokine Production
Regulation Of Developmental Process
Regulation Of Cellular Response To Stress
Regulation Of DNA Repair
DNA Damage Response
Signal Transduction In Response To DNA Damage
Positive Regulation Of DNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin Organization
Chromatin Remodeling
Regulation Of DNA Metabolic Process
DNA Repair
Double-strand Break Repair
Protein Localization To Site Of Double-strand Break
Response To Ionizing Radiation
Regulation Of Double-strand Break Repair
Nucleoplasm
Positive Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Metabolic Process
Cellular Response To Stress
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA Repair
Regulation Of Cell Cycle Process
Protein Localization To Chromosome
Response To Radiation
DNA Strand Resection Involved In Replication Fork Processing
Chromosome, Telomeric Region
Regulation Of Primary Metabolic Process
Intracellular Signal Transduction
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of DNA Recombination
Nucleic Acid Metabolic Process
Positive Regulation Of Double-strand Break Repair
DNA Damage Checkpoint Signaling
Telomere Maintenance
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Cell Cycle Process
Regulation Of Cell Cycle
Chromosome
Positive Regulation Of DNA Recombination
Positive Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Response To Stress
Telomere Organization
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Cell Cycle
Nucleus
Negative Regulation Of Cell Cycle Phase Transition
Mitotic DNA Damage Checkpoint Signaling
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