QARS and GADD45A

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		QARS	GADD45A
Gene Name		glutaminyl-tRNA synthetase	growth arrest and DNA-damage-inducible, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrial Matrix Cytosol	Nucleus Cytoplasm
	Molecular Function	Glutamine-tRNA Ligase Activity Protein Binding ATP Binding	Core Promoter Binding Protein Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Glutaminyl-tRNA Aminoacylation Brain Development Gene Expression	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Activation Of MAPKKK Activity DNA Repair Negative Regulation Of Protein Kinase Activity Apoptotic Process Cell Cycle Arrest Centrosome Cycle Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Cellular Response To Mechanical Stimulus Cellular Response To Ionizing Radiation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation Mitochondrial tRNA aminoacylation
Drugs
Diseases
GWAS
Protein-Protein Interactions		37 interactors: AES ANXA7 APP ASL CDK4 CDKN1A CLTC CPNE3 DPPA4 DTX2 DUSP11 FAM118B GADD45A GSK3B H2AFX IRF1 KCNE3 KLC3 LAMTOR3 LZTS2 MAP3K5 PIK3R3 PIN1 PRRC2A RARS RNF11 SMAD9 SMN1 STK3 TCF12 TK1 TRAF2 TRAF4 TRIP13 TSC22D1 TTR VPS37B	65 interactors: ADAP1 ASCC2 AURKA BAG6 C14orf1 CCNB1 CDK1 CDK11A CDKN1A CENPB CHD3 CLEC3B DCTN2 DNAJC13 EEF1A1 EEF1G FAM83D FAS FBN3 FTL GADD45GIP1 GAPDH GBP2 GNB2 HIST1H1A HIST1H2AL HIST2H2BE HIST3H3 HIST4H4 IGHM IGSF21 JMJD1C KHSRP LMO4 MAP3K4 MAPK14 MASP1 MDM2 MICAL1 MIDN MPP1 NPM1 NRBP1 NUCB2 PCNA PFKFB4 PPARA PSMC3 PTN PTPRK QARS RAI1 RBPJ RPS2 RXRA SH3GLB1 SPTBN4 SYNE4 TLE1 TP53 UBE2D1 UBR1 VIM ZHX1 ZNF135
Entrez ID		5859	1647
HPRD ID		07223	00528
Ensembl ID		ENSG00000172053	ENSG00000116717
Uniprot IDs		B4DWJ2 B7Z840 P47897	A5JUZ3 P24522
PDB IDs			2KG4
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Binding Regulation Of Kinase Activity Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Regulation Of Protein Phosphorylation Regulation Of Binding Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Binding Regulation Of JNK Cascade Response To Inorganic Substance Regulation Of Phosphorus Metabolic Process Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Apoptotic Process Programmed Cell Death Positive Regulation Of Transferase Activity Cell Cycle Process Metabolic Process Cell Death Death Cell Cycle Cellular Protein Modification Process Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Binding Cellular Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Catalytic Activity Regulation Of Cell Death Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Protein Homodimerization Activity Regulation Of Metabolic Process Response To Stimulus Innate Immune Response	Regulation Of Metabolic Process Cell Cycle Cell Cycle Process Regulation Of Gene Expression Mitotic Cell Cycle Mitotic Cell Cycle Process Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Organelle Organization DNA Packaging DNA Conformation Change Negative Regulation Of Cellular Metabolic Process Apoptotic Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Cell Aging Protein Complex Assembly Chromatin Organization Negative Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cell Death Death Positive Regulation Of Protein Metabolic Process Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Catabolic Process Response To Organic Substance DNA Damage Checkpoint Chromatin Assembly Or Disassembly Stress-induced Premature Senescence Immune Response Mitotic Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Gene Expression Mitotic DNA Damage Checkpoint Immune System Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cell Death Positive Regulation Of Metabolic Process Innate Immune Response Mitotic DNA Integrity Checkpoint Response To Toxic Substance Positive Regulation Of Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Proteolysis Cellular Response To Oxygen Levels
Tagcloud ?		aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured kars lysyl nerve pharmaceutical possibility powerful primers root satellite sensory spinal synthetase synthetases trna typical	2h5 accompanies anova dynactin gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase
Tagcloud (Difference) ?		aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured kars lysyl nerve pharmaceutical possibility powerful primers root satellite sensory spinal synthetase synthetases trna typical	2h5 accompanies anova dynactin gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase
Tagcloud (Intersection) ?