QARS1 and VPS37B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		QARS1	VPS37B
Description		glutaminyl-tRNA synthetase 1	VPS37B subunit of ESCRT-I
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GO Annotations	Cellular Component	Cytoplasm Mitochondrial Matrix Cytosol Aminoacyl-tRNA Synthetase Multienzyme Complex Protein-containing Complex	ESCRT I Complex Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Midbody Late Endosome Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Aminoacyl-tRNA Ligase Activity Glutamine-tRNA Ligase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Ligase Activity Protein Kinase Binding	Protein Binding Calcium-dependent Protein Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Glutaminyl-tRNA Aminoacylation Brain Development Negative Regulation Of Stress-activated MAPK Cascade TRNA Aminoacylation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Apoptotic Signaling Pathway	Protein Targeting To Membrane Protein Targeting To Vacuole Protein Transport Macroautophagy Viral Release From Host Cell Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission Positive Regulation Of Viral Budding Via Host ESCRT Complex
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS			A body shape index ( 34021172) Hip circumference adjusted for BMI ( 34021172) Tourette syndrome ( 30818990) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		158 interacting genes: ACTN2 ANXA7 APP ASL B9D2 BIRC7 BTG3 CCDC33 CDK4 CDKN1A CLTC COG6 CPNE3 CTBP2 DISC1 DNM2 DPPA4 DTX2 DUSP11 EDC3 EFHC2 ESS2 FAM118B FAM161A FAM83A GADD45A GPBP1 GSK3B GSTZ1 H2AX HES7 HMG20A HOXA1 IK IKZF1 IRF1 KCNE3 KLC3 KRT36 LAMTOR3 LGALS9B LGALS9C LNX1 LZTS1 LZTS2 MAP3K5 MCCD1 MESD MID2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR155 MIR15A MIR15B MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7G MIRLET7I NAB2 NEBL NFKBID NLGN3 NOXA1 PICK1 PIK3R3 PIN1 PRDM6 PRRC2A PTPN21 RARS1 RBFOX2 REL RNF10 RNF11 SAXO4 SF3B4 SHLD1 SLA SMAD9 SMN1 SNCA SORBS3 SP7 SPATC1L SPDYE4 SPRED2 STK3 TADA2A TCF12 TGM7 TK1 TLE5 TRAF2 TRAF4 TRIM27 TRIM35 TRIP13 TSC22D1 TTR USHBP1 VPS37B XIAP ZMYND12	27 interacting genes: BAG3 BYSL CDC73 CRK DCUN1D1 ENKD1 ERCC1 EXOC8 FBF1 GORASP2 HGS KDM1A LNX1 NCK2 OSTF1 PRKAA1 PRKAA2 QARS1 SH3YL1 SMARCD1 SORBS3 TLE5 TSG101 UBASH3A UBASH3B UBC VPS28
Entrez ID		5859	79720
HPRD ID		07223	07794
Ensembl ID		ENSG00000172053	ENSG00000139722
Uniprot IDs		B7Z840 P47897	Q9H9H4
PDB IDs		4R3Z 4YE6 4YE8 4YE9	6VME
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cytokine Production MRNA Destabilization RNA Destabilization Negative Regulation Of Translation Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Metabolic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Motility Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Cell Migration Negative Regulation Of Locomotion Regulation Of MRNA Stability Negative Regulation Of Developmental Process Regulation Of Angiogenesis Regulation Of RNA Stability Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Vasculature Development Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Translation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Endothelial Cell Migration Regulation Of Cytokine Production Regulation Of Developmental Process	Organelle Assembly Protein Localization To Vacuole Membrane Fission Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Ubiquitin-dependent Endocytosis Autophagy Endosome Organization Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Protein Localization To Lipid Droplet Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Negative Regulation Of Signal Transduction Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Localization Organelle Organization Positive Regulation Of Protein Localization Regulation Of Tubulin Deacetylation Regulation Of Protein Modification Process Lipid Droplet Disassembly Multivesicular Body Sorting Pathway Cytoplasm Protein Localization To Lysosome Phosphatidylethanolamine Biosynthetic Process Ciliary Basal Body Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Nucleotide-activated Protein Kinase Complex Establishment Of Protein Localization To Vacuole ESCRT I Complex Regulation Of Cellular Component Organization Protein-containing Complex Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Exosomal Secretion Regulation Of Signal Transduction Fatty Acid Homeostasis Hepatocyte Apoptotic Process Regulation Of Organelle Organization Cellular Response To Prostaglandin E Stimulus Regulation Of Exosomal Secretion Cellular Component Assembly Phosphatidylcholine Biosynthetic Process Positive Regulation Of Glycolytic Process
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