CEACAM1 and CEACAM6

Number of citations of the paper that reports this interaction (PubMedID 8018919)
0

Data Source:
HPRD (in vitro)

		CEACAM1	CEACAM6
Description		CEA cell adhesion molecule 1	CEA cell adhesion molecule 6
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell-cell Junction Adherens Junction Basal Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Transport Vesicle Membrane Cytoplasmic Vesicle Microvillus Membrane Specific Granule Membrane T Cell Receptor Complex Cell Projection Extracellular Exosome Anchoring Junction Tertiary Granule Membrane	Extracellular Space Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Azurophil Granule Membrane Side Of Membrane
	Molecular Function	Actin Binding Protein Binding Calmodulin Binding Bile Acid Transmembrane Transporter Activity Kinase Binding Protein Phosphatase Binding Filamin Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity Protein Tyrosine Kinase Binding	Protein Binding Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Angiogenesis Regulation Of Cell Growth Blood Vessel Development Negative Regulation Of T Cell Mediated Cytotoxicity Regulation Of Immune System Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Protein Kinase Activity Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Integrin-mediated Signaling Pathway Regulation Of Endothelial Cell Migration Bile Acid And Bile Salt Transport Cell Migration Regulation Of Cell Migration Negative Regulation Of Granulocyte Differentiation Negative Regulation Of Interleukin-1 Production Cellular Response To Insulin Stimulus Common Myeloid Progenitor Cell Proliferation Insulin Receptor Internalization Granulocyte Colony-stimulating Factor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Negative Regulation Of Cytotoxic T Cell Degranulation Wound Healing, Spreading Of Cells Regulation Of Endothelial Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Lipid Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Blood Vessel Remodeling Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Platelet Aggregation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Insulin Catabolic Process Regulation Of Homophilic Cell Adhesion Regulation Of Sprouting Angiogenesis Negative Regulation Of Hepatocyte Proliferation Positive Regulation Of Vasculogenesis	Apoptotic Process Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Negative Regulation Of Anoikis
Pathways		Fibronectin matrix formation Cell surface interactions at the vascular wall Neutrophil degranulation Regulation of MITF-M dependent genes involved in invasion	Fibronectin matrix formation Cell surface interactions at the vascular wall Neutrophil degranulation
Drugs		Technetium Tc-99m arcitumomab
Diseases
GWAS			Serum carcinoembryonic antigen levels ( 31666285)
Interacting Genes		18 interacting genes: ADRB2 ANXA2 CARTPT CD209 CEACAM3 CEACAM5 CEACAM6 CEACAM7 CEACAM8 EGFR FLNA INSR MAP3K10 PTPN11 PTPN6 PXN SHC1 SRC	32 interacting genes: APP ASPG CARTPT CEACAM1 CEACAM5 CEACAM7 CEACAM8 CIB1 CSTF2 EXOC3L1 FOXH1 GCM2 GPANK1 HGS HPCAL4 KANK2 MSS51 MYOZ1 PITX1 POM121 QRICH1 RHOXF2 SHC3 SMARCD1 TLX3 TNXB UBQLN2 VENTX VEZF1 WWOX ZMYND19 ZNF76
Entrez ID		634	4680
HPRD ID		00191	01233
Ensembl ID		ENSG00000079385	ENSG00000086548
Uniprot IDs		P13688 Q3KRG8	P40199
PDB IDs		2GK2 4QXW 4WHD 5DZL 6AW2 6GBG 6GBH 6V3P 6XNO 6XNT 6XNW 6XO1 7MU8 7RPP 8CXJ	4WHC 4WTZ 4Y8A 4YIQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Cell Adhesion Cell-cell Adhesion Positive Regulation Of Intracellular Signal Transduction Myeloid Cell Development Positive Regulation Of Signaling Negative Regulation Of Neutrophil Activation Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Signal Transduction Plasma Membrane Cell Surface Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Vasodilation Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Communication Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction Hemopoiesis Negative Regulation Of Anoikis Shc-EGFR Complex Regulation Of Intracellular Signal Transduction Negative Regulation Of Multicellular Organismal Process Positive Regulation Of ERK1 And ERK2 Cascade ERBB Signaling Pathway Megakaryocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Anoikis Negative Regulation Of Developmental Process Neutrophil Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Epidermal Growth Factor Binding Vascular Process In Circulatory System Regulation Of Apoptotic Process Side Of Membrane Symbiont Entry Into Host Cell Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Adhesion Protein Tyrosine Kinase Binding G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction T Cell Costimulation	Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Central Nervous System Development Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Developmental Process
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