EIF5A2 and PTBP2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		EIF5A2	PTBP2
Description		eukaryotic translation initiation factor 5A2	polypyrimidine tract binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane	Nucleus Spliceosomal Complex Growth Cone Neuronal Cell Body
	Molecular Function	RNA Binding Translation Elongation Factor Activity Protein Binding Ribosome Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Translation Translational Elongation Spermatogenesis Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination	MRNA Splice Site Recognition MRNA Processing RNA Splicing Spinal Cord Development Cerebellum Development Negative Regulation Of RNA Splicing Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation
Pathways		Hypusine synthesis from eIF5A-lysine
Drugs
Diseases
GWAS		C-reactive protein levels ( 30388399) Urate levels ( 31578528)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Anorexia nervosa ( 31308545) Autism spectrum disorder ( 30804558) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 20935630 28892062 28448500 25673413) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Chronotype ( 30696823) Daytime nap ( 33568662) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Headache ( 29397368) Hip circumference ( 25673412) Number of sexual partners ( 30643258) Reaction time ( 29844566) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 22688191 19571811) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 30944420 32239398) Waist circumference ( 25673412)
Interacting Genes		10 interacting genes: CDC23 DHPS FNDC3B HERC3 HIF1A NIF3L1 PTBP2 RAB30 REL SDCBP	26 interacting genes: CALCOCO2 EIF5A2 ELAVL1 GOLGA2 HNRNPAB HNRNPC HNRNPD ISY1 KHDRBS1 KHDRBS3 KHSRP LINC00624 MAGOH MATR3 OGT PCBP2 PCBP3 PRDX4 PUF60 QKI RBM10 RBM4 RBPMS2 SNRPA SRPK2 TOM1
Entrez ID		56648	58155
HPRD ID		10426	12233
Ensembl ID		ENSG00000163577	ENSG00000117569
Uniprot IDs		Q9GZV4	A0A6Q8PFE6 A0A7I2RVZ4 B4DSS8 B4DSU5 Q9UKA9
PDB IDs			2CQ1 2MJU 4CQ1
Enriched GO Terms of Interacting Partners?			Regulation Of MRNA Metabolic Process Nucleic Acid Binding RNA Binding MRNA Metabolic Process MRNA Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Processing Regulation Of RNA Splicing RNA Metabolic Process Post-transcriptional Regulation Of Gene Expression RNA Splicing RNA Processing RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Catabolic Process MiRNA Binding Negative Regulation Of RNA Catabolic Process Nucleic Acid Metabolic Process Negative Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process MRNA Stabilization Negative Regulation Of Catabolic Process Ribonucleoprotein Complex Nucleus Positive Regulation Of Translation RNA Stabilization Regulation Of Translation Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Gene Expression Regulation Of Gene Expression Circadian Regulation Of Translation Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process 3'-UTR-mediated MRNA Stabilization Regulation Of Nucleobase-containing Compound Metabolic Process MRNA 3'-UTR AU-rich Region Binding Cytoplasmic Stress Granule Regulation Of Primary Metabolic Process Nucleoplasm Positive Regulation Of Protein-containing Complex Disassembly Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Metabolic Process Non-canonical Inflammasome Complex Assembly Negative Regulation Of Gene Expression
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