EIF5A2 and DHPS

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		EIF5A2	DHPS
Description		eukaryotic translation initiation factor 5A2	deoxyhypusine synthase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane	Cytoplasm Cytosol
	Molecular Function	RNA Binding Translation Elongation Factor Activity Protein Binding Ribosome Binding	Protein Binding Transferase Activity Deoxyhypusine Synthase Activity Identical Protein Binding
	Biological Process	Translation Translational Elongation Spermatogenesis Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination	Translation Spermidine Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of T Cell Proliferation Glucose Homeostasis Spermidine Catabolic Process Protein Maturation
Pathways		Hypusine synthesis from eIF5A-lysine	Hypusine synthesis from eIF5A-lysine
Drugs			1-Guanidinium-7-Aminoheptane
Diseases
GWAS		C-reactive protein levels ( 30388399) Urate levels ( 31578528)	Platelet distribution width ( 32888494)
Interacting Genes		10 interacting genes: CDC23 DHPS FNDC3B HERC3 HIF1A NIF3L1 PTBP2 RAB30 REL SDCBP	16 interacting genes: BRCA1 EIF5A EIF5A2 LNX1 MEOX2 NIF3L1 NTAQ1 NUDT18 PAX6 PTPRH RAB27B RBP1 REL RPL9 VASH1 ZNF138
Entrez ID		56648	1725
HPRD ID		10426	02969
Ensembl ID		ENSG00000163577	ENSG00000095059
Uniprot IDs		Q9GZV4	P49366
PDB IDs			1DHS 1RLZ 1ROZ 1RQD 6P4V 6PGR 6WKZ 6WL6 6XXH 6XXI 6XXJ 6XXK 6XXL 6XXM 7A6S 7A6T 8A0E 8A0F 8A0G 8PVU 8R3U
Enriched GO Terms of Interacting Partners?			Regulation Of Translational Termination Positive Regulation Of Translational Termination Positive Regulation Of Translational Elongation Regulation Of Translational Elongation Translation Elongation Factor Activity Regulation Of Protein-containing Complex Disassembly Cytoplasm Positive Regulation Of Protein-containing Complex Disassembly Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Protein-N-terminal Glutamine Amidohydrolase Activity 8-hydroxy-dADP Phosphatase Activity 8-oxo-GDP Phosphatase Activity DGDP Catabolic Process DADP Catabolic Process
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