RBPMS2 and CBX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RBPMS2	CBX2
Description		RNA binding protein, mRNA processing factor 2	chromobox 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule	Euchromatin Heterochromatin Nucleus Nucleoplasm Chromosome PcG Protein Complex PRC1 Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity	DNA Binding Chromatin Binding Protein Binding Histone H3K9me2/3 Reader Activity
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of BMP Signaling Pathway Embryonic Digestive Tract Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Sex Differentiation Cell Differentiation Development Of Primary Sexual Characteristics
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases			46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Coronary artery disease ( 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neuroticism ( 29255261) Platelet count ( 32888494) PR interval ( 32439900)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		68 interacting genes: ACTMAP AOC1 ARID5A BHLHE40 BOLL C10orf55 CAMK2A CBX2 CELF4 DND1 ESRP1 FAM168A FOXD4L1 FOXD4L3 FOXH1 FUBP3 HNRNPC HNRNPK HNRNPU IFIT2 KLF1 KLHDC7B KRTAP11-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP8-1 LASP1 MAGED1 MKRN3 MSX2 MYPOP PATZ1 PCBP1 PPP1R37 PRR20A PRR20B PRR20C PRR20D PRR20E PTBP2 RALY RBFOX1 RBFOX2 RBM3 RBM41 RBM42 RBM46 RBPMS RHOXF2 SEMA3B SNRPA SPMIP9 STRBP TENT5B TIAL1 UFSP1 UNC119 USP54 VHL VPS37C ZBTB32 ZC3H10 ZMAT5 ZNF34 ZNF385C	25 interacting genes: BOLL CYSRT1 DHX57 H3-3A H3-4 H3C1 H3C14 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP2-4 KRTAP4-12 KRTAP4-4 MDFI MEOX2 RBMY1A1 RBMY1F RBMY1J RBPMS2 RYBP TRIM55 TRIM63
Entrez ID		348093	84733
HPRD ID		18601	14397
Ensembl ID		ENSG00000166831	ENSG00000173894
Uniprot IDs		Q6ZRY4	Q14781
PDB IDs		2M9K	2D9U 3H91 5EPK
Enriched GO Terms of Interacting Partners?		Nucleic Acid Binding Regulation Of MRNA Metabolic Process Negative Regulation Of MRNA Metabolic Process RNA Binding Regulation Of RNA Splicing MRNA Binding RNA Splicing MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Negative Regulation Of RNA Metabolic Process Regulation Of MRNA Processing Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Stabilization MRNA Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Primary Metabolic Process Negative Regulation Of RNA Catabolic Process Intermediate Filament Negative Regulation Of RNA Splicing Regulation Of Gene Expression Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Stability Regulation Of Macromolecule Biosynthetic Process MRNA 3'-UTR Binding Protein Binding Ribonucleoprotein Complex Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Pre-mRNA Binding Negative Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression DNA Binding Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II	Keratin Filament Intermediate Filament Structural Constituent Of Chromatin Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Nucleosome Assembly Regulation Of MRNA Splicing, Via Spliceosome Nucleosome Positive Regulation Of RNA Splicing Nucleosome Organization Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Protein-DNA Complex Assembly Hair Cycle Identical Protein Binding Positive Regulation Of MRNA Metabolic Process Protein Heterodimerization Activity Chromatin Remodeling Spliceosomal Complex
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