PLEKHA4 and PRKAA1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PLEKHA4	PRKAA1
Gene Name		pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	protein kinase, AMP-activated, alpha 1 catalytic subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Cytoplasm Membrane	Intracellular Nucleus Nucleoplasm Cytoplasm Cytosol Apical Plasma Membrane AMP-activated Protein Kinase Complex
	Molecular Function	1-phosphatidylinositol Binding	Chromatin Binding Protein Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Kinase Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Tau-protein Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity
	Biological Process	Biological_process	Activation Of MAPK Activity Response To Hypoxia Glucose Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Autophagy Cell Cycle Arrest Signal Transduction Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Response To UV Cold Acclimation Response To Gamma Radiation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Response To Activity Wnt Signaling Pathway Fatty Acid Oxidation Response To Caffeine Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Histone-serine Phosphorylation Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Glucosylceramide Biosynthetic Process Rhythmic Process Negative Regulation Of Lipid Catabolic Process Protein Heterooligomerization Fatty Acid Homeostasis Regulation Of Vesicle-mediated Transport Cellular Response To Hydrogen Peroxide Cellular Response To Ethanol Cellular Response To Hypoxia Response To Camptothecin Regulation Of Energy Homeostasis Negative Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways			Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs		Inositol 1,3,4,5-Tetrakisphosphate	Adenosine monophosphate Adenosine triphosphate Phenformin
Diseases
GWAS			Gastric cancer ( 22037551)
Protein-Protein Interactions		6 interactors: CCNG1 EEF1G KAT5 LRIF1 PRKAA1 SETDB1	58 interactors: ABI2 ACACA AES BHLHE40 CAB39 CDX4 CFTR CRTC2 CTBP1 EEF2K EPM2A FNIP1 GATA1 GOLGA2 GRIK2 HDAC5 HMBOX1 HOMEZ IKZF3 INO80E KRT40 L3MBTL3 MAP3K7 MDM4 MORC4 MTOR MTUS2 PFKFB2 PHC2 PLEKHA4 PNMA5 PPP2CA PRKAB1 PRKAB2 PRKAG1 PRKAG3 PSMD11 RAD54B RAF1 RBPMS RFX6 RIMBP3 ROPN1 RPTOR SRPK2 SSX2IP STK11 THAP1 TOMM34 TRIM27 TRIP6 TSC2 TSC22D4 TXNIP UBXN11 VPS37B VPS52 ZBED1
Entrez ID		57664	5562
HPRD ID		09683	04115
Ensembl ID		ENSG00000105559	ENSG00000132356
Uniprot IDs		Q9H4M7	Q13131
PDB IDs		1UPQ 1UPR
Enriched GO Terms of Interacting Partners?		Histone Modification Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Chromatin Modification Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Organization Response To Ionizing Radiation Negative Regulation Of Glucose Import In Response To Insulin Stimulus Response To Camptothecin Transcription, DNA-templated Peptidyl-amino Acid Modification RNA Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Chromosome Organization Peptidyl-lysine Modification Biosynthetic Process Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Histone H3-K9 Trimethylation Cellular Response To Ethanol Negative Regulation Of Glucose Import Regulation Of Energy Homeostasis Positive Regulation Of Glycolytic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Biosynthetic Process DNA Damage Response, Signal Transduction Resulting In Transcription Fatty Acid Homeostasis Organelle Organization RNA Metabolic Process Negative Regulation Of Glucose Transport Mitotic G2 DNA Damage Checkpoint Cellular Response To Stress Cellular Response To Estradiol Stimulus Negative Regulation Of Interleukin-2 Production Negative Regulation Of Cell Cycle Response To Radiation Histone H3-K9 Methylation Regulation Of Glucose Import In Response To Insulin Stimulus Inner Cell Mass Cell Proliferation Regulation Of Cholesterol Biosynthetic Process Histone-serine Phosphorylation Growth Negative Regulation Of Lipid Catabolic Process Cellular Response To Glucose Starvation Positive Regulation Of Protein Acetylation Peptidyl-lysine Trimethylation Response To Caffeine	Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Peptide Hormone Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Response To Hormone Cell Cycle Arrest Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Kinase Activity Gene Expression Response To Organonitrogen Compound Transcription, DNA-templated Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process RNA Biosynthetic Process Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Biosynthetic Process Cell Cycle Response To Organic Substance Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Phosphorylation Cellular Response To Organic Substance Protein Oligomerization RNA Metabolic Process Positive Regulation Of Protein Phosphorylation Protein Heterooligomerization Negative Regulation Of Transcription, DNA-templated Protein Phosphorylation
Tagcloud ?			abeta anticipate atg7 autophagic autophagy catabolic clearance cultures degraded degrades enhancing extracellular fibrils inflammasome ingests interacts knockout lysosomal map1lc3b microglia microglial native nlr nlrp3 optineurin optn promising pyrin resultant
Tagcloud (Difference) ?			abeta anticipate atg7 autophagic autophagy catabolic clearance cultures degraded degrades enhancing extracellular fibrils inflammasome ingests interacts knockout lysosomal map1lc3b microglia microglial native nlr nlrp3 optineurin optn promising pyrin resultant
Tagcloud (Intersection) ?