RPS6KB1 and NCBP1

Number of citations of the paper that reports this interaction (PMID 10973943)
18

Data Source:
HPRD (in vivo)

		RPS6KB1	NCBP1
Gene Name		ribosomal protein S6 kinase, 70kDa, polypeptide 1	nuclear cap binding protein subunit 1, 80kDa
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cell Surface Cell Junction Neuron Projection Synapse Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol MRNA Cap Binding Complex Nuclear Cap Binding Complex Ribonucleoprotein Complex
	Molecular Function	Protein Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Peptide Binding	RNA Cap Binding RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Skeletal Muscle Contraction Protein Phosphorylation Apoptotic Process Signal Transduction Germ Cell Development Aging Response To Nutrient Long-term Memory Insulin Receptor Signaling Pathway Response To Heat Response To Wounding Response To Mechanical Stimulus Response To Toxic Substance Response To Glucose Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Smooth Muscle Cell Migration Cell Migration TOR Signaling Response To Lipopolysaccharide Response To Testosterone Response To Glucagon Response To Tumor Necrosis Factor Response To Drug Negative Regulation Of Apoptotic Process Response To Leucine Protein Kinase B Signaling Response To Ethanol Positive Regulation Of Translation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Translational Initiation Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Smooth Muscle Cell Proliferation Response To Glucocorticoid Cellular Response To Growth Factor Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription 7-methylguanosine MRNA Capping MRNA Cleavage MRNA Export From Nucleus Regulation Of Translational Initiation Histone MRNA Metabolic Process RNA Splicing Gene Expression Viral Process Gene Silencing By RNA MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing NcRNA Metabolic Process MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Viral Transcription
Pathways		Insulin receptor signalling cascade IRS-mediated signalling mTOR signalling S6K1 signalling S6K1-mediated signalling IRS-related events mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade S6K1-mediated signalling mTORC1-mediated signalling IRS-related events triggered by IGF1R IRS-mediated signalling S6K1 signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PKB-mediated events PI3K Cascade PI3K Cascade Signaling by Insulin receptor	mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Tat-mediated elongation of the HIV-1 transcript Cleavage of Growing Transcript in the Termination Region Processing of Intronless Pre-mRNAs RNA Polymerase II Pre-transcription Events SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs HIV Life Cycle Transport of Mature Transcript to Cytoplasm HIV Transcription Elongation SLBP independent Processing of Histone Pre-mRNAs Nonsense-Mediated Decay (NMD) Transport of Mature mRNA Derived from an Intronless Transcript Processing of Capped Intron-Containing Pre-mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Capping Transport of Mature mRNAs Derived from Intronless Transcripts mRNA Splicing - Minor Pathway Metabolism of non-coding RNA mRNA Splicing - Major Pathway mRNA 3'-end processing Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) snRNP Assembly Formation of HIV elongation complex in the absence of HIV Tat Processing of Capped Intronless Pre-mRNA Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Termination Transcription of the HIV genome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661)	Thyroid cancer (Papillary, radiation-related) ( 20350937)
Protein-Protein Interactions		54 interactors: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B DPPA4 EEF2K EIF4B EIF4EBP1 EP300 GDI2P1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MLST8 MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RICTOR RPS6 RPTOR SRC STK11 SYK TERT TRAF4 URI1 XPO1	14 interactors: BNIP1 BNIP2 BNIP3 C17orf85 EIF4G1 EIF4G2 HNRNPF HNRNPH1 NCBP2 RNF40 RPS6KB1 SNRPA1 STAU1 ZDHHC17
Entrez ID		6198	4686
HPRD ID		10202	02717
Ensembl ID		ENSG00000108443	ENSG00000136937
Uniprot IDs		B2R779 B4DLT4 B4DTG1 F6UYM1 P23443 Q7Z721	Q09161
PDB IDs		3A60 3A61 3A62 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46	1H2T 1H2U 1H2V 1H6K 1N52 1N54 3FEX 3FEY
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Insulin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Cellular Protein Metabolic Process Cellular Response To Peptide Cellular Response To Organonitrogen Compound Fc Receptor Signaling Pathway Cellular Response To Hormone Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Hormone Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Response To Peptide Hormone Positive Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Peptide Regulation Of Signal Transduction Regulation Of Phosphorylation Cellular Response To Stimulus Positive Regulation Of Protein Phosphorylation Response To Organonitrogen Compound Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Signal Transduction Regulation Of Signaling Innate Immune Response Intracellular Signal Transduction Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Cell Communication Immune Response Positive Regulation Of Protein Modification Process Regulation Of Kinase Activity Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Metabolic Process T Cell Costimulation Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway	Regulation Of Translational Initiation MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing Regulation Of Translation RNA Splicing Posttranscriptional Regulation Of Gene Expression Cell Death Death Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Positive Regulation Of Viral Process MRNA 3'-end Processing Cellular Macromolecule Catabolic Process Endoplasmic Reticulum Membrane Fusion SnRNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of RNA Splicing Apoptotic Process Negative Regulation Of Cell Death RNA 3'-end Processing Positive Regulation By Virus Of Viral Protein Levels In Host Cell Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Mitochondrial Protein Catabolic Process Programmed Cell Death Catabolic Process Cellular Metabolic Process Skeletal Muscle Atrophy Negative Regulation Of Mitochondrial Fusion Granzyme-mediated Apoptotic Signaling Pathway Nuclear-transcribed MRNA Catabolic Process Viral Process RNA Localization Insulin Receptor Signaling Pathway Autophagic Cell Death Striated Muscle Atrophy Response To Leucine Regulation Of Mitochondrial Fusion Regulation Of Viral Process MRNA Catabolic Process Cellular Response To Cobalt Ion Muscle Atrophy RNA Catabolic Process Skeletal Muscle Adaptation Histone H2B Ubiquitination
Tagcloud ?		70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rictor s6k1 senescent ureahydrolase wk	adaptation cdna delayed elicited equivalent fundamental heat implicates ischaemia ischaemic isoform lethal mediating modulating myocardium pp2 preconditioning rabbit rda rendered reperfusion representational salvage se sham shock tgfbeta trip1 ventricle
Tagcloud (Difference) ?		70kda ablation amp ampk aortas apoe apolipoprotein arg2 arginase atherogenesis atherosclerosis atherosclerotic autophagy crosstalk h160f impairs interested mtorc1 mtorc2 nonsenescent polypeptide prkaa replicative rictor s6k1 senescent ureahydrolase wk	adaptation cdna delayed elicited equivalent fundamental heat implicates ischaemia ischaemic isoform lethal mediating modulating myocardium pp2 preconditioning rabbit rda rendered reperfusion representational salvage se sham shock tgfbeta trip1 ventricle
Tagcloud (Intersection) ?