CILK1 and CDK20

Number of citations of the paper that reports this interaction (PubMedID 16954377)
69

Data Source:
BioGRID (enzymatic study)

		CILK1	CDK20
Description		ciliogenesis associated kinase 1	cyclin dependent kinase 20
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Cilium Ciliary Basal Body Cell Projection Ciliary Tip Ciliary Base	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cilium Cell Projection
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Cell Projection Organization Intracellular Signal Transduction Intraciliary Anterograde Transport Intraciliary Retrograde Transport Intraciliary Transport Cilium Assembly	Neural Tube Closure Regulation Of Smoothened Signaling Pathway Floor Plate Formation Embryonic Camera-type Eye Development Negative Regulation Of Smoothened Signaling Pathway Embryonic Skeletal System Development Cell Division Regulation Of Cell Cycle Roof Of Mouth Development Protein Localization To Cilium Regulation Of Protein Maturation Embryonic Brain Development
Pathways
Drugs		Fostamatinib
Diseases		Endocrine-cerebro-osteodysplasia syndrome
GWAS
Interacting Genes		6 interacting genes: APP BAG6 CDK20 FBXO7 RPTOR SMAD1	9 interacting genes: CCNH CDK2 CILK1 CSNK2B GTF2IRD1 GTF2IRD2 PANK4 PPP5C TRIM2
Entrez ID		22858	23552
HPRD ID		09996	13010
Ensembl ID		ENSG00000112144	ENSG00000156345
Uniprot IDs		A0A7I2PIU1 B3KQG4 Q9UPZ9	A0A0S2Z562 A0A0S2Z5B6 Q8IZL9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catabolic Process Positive Regulation Of Glycolytic Process Positive Regulation Of ATP Metabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Developmental Process Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Regulation Of MiRNA Transcription Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Cell Cycle Protein Kinase Binding Ubiquitin Protein Ligase Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of MiRNA Metabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Activator Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization PTB Domain Binding Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Immune System Process Regulation Of Cell Differentiation Endosome To Plasma Membrane Transport Vesicle Regulation Of Protein Metabolic Process Cellular Homeostasis Positive Regulation Of Endothelin Production Growth Cone Filopodium Receptor Ligand Activity Lipoprotein Particle Intracellular Chemical Homeostasis Regulation Of Multicellular Organismal Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Protein Import Cell Activation Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Mesodermal Cell Fate Commitment	Phosphate-containing Compound Metabolic Process Phosphorylation Protein Phosphorylation DNA-templated Transcription Nucleobase-containing Compound Biosynthetic Process Protein Modification Process Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Male Germ Cell Nucleus ATP Binding Brain-derived Neurotrophic Factor Receptor Activity Transition Between Slow And Fast Fiber Macromolecule Metabolic Process Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Phosphatase Activity Pantothenate Kinase Activity Transcription Factor TFIIK Complex Positive Regulation Of Chromatin Organization Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Brain-derived Neurotrophic Factor Binding Response To Arachidonate Peptidyl-serine Dephosphorylation CAK-ERCC2 Complex X Chromosome Brain-derived Neurotrophic Factor Receptor Signaling Pathway Neurotrophin Receptor Activity Trans-synaptic Signaling By BDNF Neurotrophin Binding Protein Kinase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Release From Viral Latency Pantothenate Metabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Protection From Non-homologous End Joining At Telomere
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