ICK and RPTOR

Number of citations of the paper that reports this interaction (PMID 22356909)
3

Data Source:
BioGRID (enzymatic study, biochemical)

		ICK	RPTOR
Gene Name		intestinal cell (MAK-like) kinase	regulatory associated protein of MTOR, complex 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Ciliary Basal Body Ciliary Tip	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Dendrite TORC1 Complex Neuronal Cell Body Intracellular Membrane-bounded Organelle
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	RNA Polymerase III Type 1 Promoter DNA Binding RNA Polymerase III Type 2 Promoter DNA Binding RNA Polymerase III Type 3 Promoter DNA Binding TFIIIC-class Transcription Factor Binding Protein Binding Protein Kinase Binding Protein Complex Binding 14-3-3 Protein Binding
	Biological Process	Protein Phosphorylation Signal Transduction Multicellular Organismal Development Intracellular Signal Transduction Intraciliary Transport Cilium Assembly Regulation Of Cell Cycle	Positive Regulation Of Endothelial Cell Proliferation Cell Cycle Arrest Insulin Receptor Signaling Pathway Regulation Of Cell Size Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Cellular Response To Heat Positive Regulation Of Transcription From RNA Polymerase III Promoter Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Response To Heat
Pathways			IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade IRS-related events triggered by IGF1R HSF1-dependent transactivation Release of eIF4E Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Release of eIF4E Cellular response to heat stress S6K1-mediated signalling mTORC1-mediated signalling IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS			Obesity ( 23563607)
Protein-Protein Interactions		5 interactors: APP BAG6 CDK20 RPTOR SMAD1	20 interactors: AKT1S1 EIF4EBP1 ICK IRS1 IRS2 MAPK1 MAPK3 MARK4 MLST8 MTOR PLD2 PRKAA1 PRKAA2 PRR5L RAP1B RHEB RPS6KA1 RPS6KB1 RRAGA RRAGB
Entrez ID		22858	57521
HPRD ID		09996	06184
Ensembl ID		ENSG00000112144	ENSG00000141564
Uniprot IDs		B3KQG4 Q9UPZ9	F5H7J5 Q6DKI0 Q8N122
PDB IDs
Enriched GO Terms of Interacting Partners?		Posttranscriptional Regulation Of Gene Expression Growth Brain Development Sexual Reproduction Head Development Cell Growth Synaptic Growth At Neuromuscular Junction Regulation Of Cell Cycle Collateral Sprouting In Absence Of Injury Central Nervous System Development Reproduction Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Primary MiRNA Processing Axon Choice Point Recognition Tail-anchored Membrane Protein Insertion Into ER Membrane Osteoblast Fate Commitment Cellular Protein Modification Process Reproductive Process Positive Regulation Of Transcription, DNA-templated Protein Phosphorylation Kidney Development Cell Cycle Protein Insertion Into ER Membrane Renal System Development Neuron Remodeling Response To Stress Positive Regulation Of Transcription From RNA Polymerase III Promoter Negative Regulation Of Proteolysis Regulation Of Cell Proliferation Negative Regulation Of Protein Processing Positive Regulation Of Macromolecule Biosynthetic Process SMAD Protein Complex Assembly Urogenital System Development Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Processing Mesodermal Cell Fate Commitment Cellular Copper Ion Homeostasis Cardiac Muscle Cell Proliferation Intracellular Signal Transduction Phosphorylation Protein Insertion Into Membrane TOR Signaling Cellular Component Assembly Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of TOR Signaling Synaptonemal Complex Assembly Cellular Response To BMP Stimulus	Cellular Response To Organonitrogen Compound Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Response To Peptide Hormone Enzyme Linked Receptor Protein Signaling Pathway Regulation Of TOR Signaling Response To Peptide Neurotrophin Signaling Pathway Cellular Response To Hormone Stimulus Intracellular Signal Transduction Cell Communication Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Response To Heat Response To Hormone Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Response To Stress Cellular Response To Fibroblast Growth Factor Stimulus Response To Temperature Stimulus Response To Fibroblast Growth Factor Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Heat Fc-epsilon Receptor Signaling Pathway Response To Stimulus TOR Signaling Signaling Positive Regulation Of Signal Transduction Phosphatidylinositol-mediated Signaling Regulation Of Intracellular Signal Transduction Cellular Response To Heat Positive Regulation Of TOR Signaling JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Tagcloud ?		allergen astacin biotechnological bites brown continents cystine dermonecrosis gravitational hemolysis hyaluronidases intravascular knot loxosceles loxoscelism manifestations metalloproteases noxious occasional phospholipases spider spiders spreading tctp thrombocytopenia toxins translationally venom venoms	ablation balanced cns complexes contributions delicately functionally hypomyelination integrates lipogenesis lipogenic minor mtor mtorc1 mtorc2 myelin myelination oligodendrocyte oligodendrocytes overactivation overtones practical rapamycin reliant rictor sclerosis tsc1 tuberous
Tagcloud (Difference) ?		allergen astacin biotechnological bites brown continents cystine dermonecrosis gravitational hemolysis hyaluronidases intravascular knot loxosceles loxoscelism manifestations metalloproteases noxious occasional phospholipases spider spiders spreading tctp thrombocytopenia toxins translationally venom venoms	ablation balanced cns complexes contributions delicately functionally hypomyelination integrates lipogenesis lipogenic minor mtor mtorc1 mtorc2 myelin myelination oligodendrocyte oligodendrocytes overactivation overtones practical rapamycin reliant rictor sclerosis tsc1 tuberous
Tagcloud (Intersection) ?