HECW2 and TP73

Number of citations of the paper that reports this interaction (PMID 12890487)
21

Data Source:
HPRD (in vitro, in vivo)

		HECW2	TP73
Gene Name		HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	tumor protein p73
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Factor Complex Golgi Apparatus Cytosol Cell Junction Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Ligase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription P53 Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Kidney Development Release Of Cytochrome C From Mitochondria Mismatch Repair Transcription From RNA Polymerase II Promoter Inflammatory Response Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Post-embryonic Development Response To X-ray Response To Organonitrogen Compound Response To Gamma Radiation Regulation Of Gene Expression Hippocampus Development Mitotic G1 DNA Damage Checkpoint Cerebrospinal Fluid Secretion Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of JUN Kinase Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Neuron Development Positive Regulation Of Oligodendrocyte Differentiation Protein Tetramerization Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways
Drugs
Diseases
GWAS			Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Visceral fat ( 22589738)
Protein-Protein Interactions		3 interactors: ANAPC11 FZR1 TP73	50 interactors: ABL1 AURKA BIN1 BUB1B CABLES1 CCNB1 CCND1 CCNE1 CDK1 CDK2 CEBPZ CHD3 CREBBP DAXX EP300 FBXO45 GNB2L1 HECW2 HIPK2 HIPK3 HMGB1 HRAS IKBKB ITCH KAT2B MAPK8 MDM2 MDM4 MYC NEDD4 NFYB PFDN5 PIAS1 PIN1 PML PPP1R13B RANBP9 RBX1 RCHY1 SMAD2 SMAD3 SUMO1 TDG TP53 TP63 UBE2I WT1 WWOX XPO1 YAP1
Entrez ID		57520	7161
HPRD ID		17099	03587
Ensembl ID		ENSG00000138411	ENSG00000078900
Uniprot IDs		Q9P2P5	C9J521 O15350
PDB IDs		2LFE	1COK 1DXS 2KBY 2WQI 2WQJ 2WTT 2XWC 3VD0 3VD1 3VD2 4A63 4G82 4G83 4GUQ
Enriched GO Terms of Interacting Partners?		Cell Cycle Checkpoint Negative Regulation Of Transferase Activity Protein K11-linked Ubiquitination Regulation Of Cell Cycle Process Positive Regulation Of Transferase Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catalytic Activity Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Cell Cycle Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Metabolic Process Protein Polyubiquitination Cell Cycle Regulation Of Protein Ubiquitination Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Catalytic Activity Regulation Of Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Proteasomal Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Proteolysis Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Activation Of Anaphase-promoting Complex Activity	Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Protein Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Apoptotic Process Programmed Cell Death Negative Regulation Of Cell Cycle Cell Cycle Process Regulation Of Signal Transduction Cell Death Cellular Response To Stress Death Positive Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To DNA Damage Stimulus Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Response To Stress Mitotic Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Death Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Proteolysis Negative Regulation Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		aml candidate considerable contribute database evolution evolved gata germline heterogeneity heterozygous immunodeficiency leukocytes manifestations marrow mds mesenchymal missense mononuclear narrowing ncbi nonsynonymous nucleotide overlapping polymorphism predisposition r330x suggestive termed	acidic amylin calcitonin calcr causally deltan glycolysis iapp implement interplay isoforms lymphomas manipulating p63 pramlintide ramp3 reactivation reprogramming resemble suppressive ta tap63 tap73 therapeutically thymic tp53 tp63 tumours
Tagcloud (Difference) ?		aml candidate considerable contribute database evolution evolved gata germline heterogeneity heterozygous immunodeficiency leukocytes manifestations marrow mds mesenchymal missense mononuclear narrowing ncbi nonsynonymous nucleotide overlapping polymorphism predisposition r330x suggestive termed	acidic amylin calcitonin calcr causally deltan glycolysis iapp implement interplay isoforms lymphomas manipulating p63 pramlintide ramp3 reactivation reprogramming resemble suppressive ta tap63 tap73 therapeutically thymic tp53 tp63 tumours
Tagcloud (Intersection) ?