HECW2

Gene Name		HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Ligase Activity
	Biological Process	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: ANAPC11 FZR1 TP73
Entrez ID		57520
HPRD ID		17099
Ensembl ID		ENSG00000138411
Uniprot IDs		Q9P2P5
PDB IDs		2LFE
Enriched GO Terms of Interacting Partners?		Cell Cycle Checkpoint Negative Regulation Of Transferase Activity Protein K11-linked Ubiquitination Regulation Of Cell Cycle Process Positive Regulation Of Transferase Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catalytic Activity Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Cell Cycle Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Metabolic Process Protein Polyubiquitination Cell Cycle Regulation Of Protein Ubiquitination Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Catalytic Activity Regulation Of Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Proteasomal Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Proteolysis Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Activation Of Anaphase-promoting Complex Activity
Tagcloud ?		aml candidate considerable contribute database evolution evolved gata germline heterogeneity heterozygous immunodeficiency leukocytes manifestations marrow mds mesenchymal missense mononuclear narrowing ncbi nonsynonymous nucleotide overlapping polymorphism predisposition r330x suggestive termed