HECW2

Description		HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
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GO Annotations	Cellular Component	Cytoplasm Spindle Cytoskeleton Mitotic Spindle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Dendrite Morphogenesis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Response to fenofibrate (LDL cholesterol levels) ( 27002377)
Interacting Genes		8 interacting genes: CBX1 CBX3 CBX5 FZR1 TP73 UBE2D2 UBE2D3 UBE2L3
Entrez ID		57520
HPRD ID		17099
Ensembl ID		ENSG00000138411
Uniprot IDs		A0A2R8Y6F3 Q9P2P5
PDB IDs		2LFE
Enriched GO Terms of Interacting Partners?		DNA Damage Response Ubiquitin Conjugating Enzyme Activity Pericentric Heterochromatin Protein K11-linked Ubiquitination Site Of DNA Damage Heterochromatin Protein Polyubiquitination Ubiquitin-protein Transferase Activator Activity Nucleoplasm Chromocenter Cellular Response To Stress Histone Methyltransferase Binding Heterochromatin Formation Chromosome, Centromeric Region Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Regulation Of Protein Targeting To Mitochondrion Epigenetic Regulation Of Gene Expression Cellular Response To Glucocorticoid Stimulus Post-translational Protein Modification Nucleus Cellular Response To Corticosteroid Stimulus Protein Autoubiquitination Enzyme Binding Cellular Response To Steroid Hormone Stimulus Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Macromolecule Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Primary Metabolic Process Positive Regulation Of Lung Ciliated Cell Differentiation Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Chromatin Binding Regulation Of RNA Metabolic Process Proteolysis DNA Repair Chromatin Lock Complex DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Post-translational Protein Modification Response To Glucocorticoid
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