HECW2 and FZR1

Number of citations of the paper that reports this interaction (PMID 24163370)
0

Data Source:
BioGRID (pull down)

		HECW2	FZR1
Gene Name		HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	fizzy/cell division cycle 20 related 1 (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Ligase Activity	Protein Binding
	Biological Process	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Mitotic Cell Cycle DNA Repair Mitotic Nuclear Division Positive Regulation Of Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process G2 DNA Damage Checkpoint Regulation Of Meiosis Positive Regulation Of Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Anaphase-promoting Complex Activity Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Negative Regulation Of Cell Aging
Pathways			APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Cellular Senescence Phosphorylation of Emi1 Orc1 removal from chromatin Autodegradation of Cdh1 by Cdh1:APC/C Class I MHC mediated antigen processing & presentation Removal of licensing factors from origins Switching of origins to a post-replicative state Synthesis of DNA Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of DNA replication Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase S Phase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins Orc1 removal from chromatin SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Cyclin A:Cdk2-associated events at S phase entry Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ANAPC11 FZR1 TP73	42 interactors: ANAPC1 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BUB1B C7orf25 CCNA2 CCNB1 CDC14A CDC20 CDC25A CDC27 CDC6 CDK1 CDK2 CDR2 CDT1 CLSPN DNAJA1 E2F3 FBXO5 HECW2 MAK MAPK8 MOAP1 PLK1 PTEN PTTG1 RBBP8 SIRT2 SKIL SKP2 SOX2 TK1 TP53 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2S
Entrez ID		57520	51343
HPRD ID		17099	04687
Ensembl ID		ENSG00000138411
Uniprot IDs		Q9P2P5	Q9UM11
PDB IDs		2LFE
Enriched GO Terms of Interacting Partners?		Cell Cycle Checkpoint Negative Regulation Of Transferase Activity Protein K11-linked Ubiquitination Regulation Of Cell Cycle Process Positive Regulation Of Transferase Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catalytic Activity Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Cell Cycle Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Metabolic Process Protein Polyubiquitination Cell Cycle Regulation Of Protein Ubiquitination Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Catalytic Activity Regulation Of Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Proteasomal Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Proteolysis Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Activation Of Anaphase-promoting Complex Activity	Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cell Cycle Cell Cycle Process Regulation Of Chromosome Segregation Mitotic Nuclear Division Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Cell Division Modification-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Cell Cycle Checkpoint Positive Regulation Of Ligase Activity Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Cellular Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Cell Cycle Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Cellular Macromolecule Catabolic Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Mitotic Cell Cycle Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Chromosome Organization Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Chromosome Segregation Negative Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		aml candidate considerable contribute database evolution evolved gata germline heterogeneity heterozygous immunodeficiency leukocytes manifestations marrow mds mesenchymal missense mononuclear narrowing ncbi nonsynonymous nucleotide overlapping polymorphism predisposition r330x suggestive termed	anaphase cdc20 cdh1 chromosomes clathrin clta cltc concentrated diffusely g2 gst interactor kinetochore localize mad2b mad2l2 misaligned mitotic p11 prcc pull q21 rccs redistribution shuttle spindle tfe3 trimeric triskelion
Tagcloud (Difference) ?		aml candidate considerable contribute database evolution evolved gata germline heterogeneity heterozygous immunodeficiency leukocytes manifestations marrow mds mesenchymal missense mononuclear narrowing ncbi nonsynonymous nucleotide overlapping polymorphism predisposition r330x suggestive termed	anaphase cdc20 cdh1 chromosomes clathrin clta cltc concentrated diffusely g2 gst interactor kinetochore localize mad2b mad2l2 misaligned mitotic p11 prcc pull q21 rccs redistribution shuttle spindle tfe3 trimeric triskelion
Tagcloud (Intersection) ?