HECW2 and CBX3

Number of citations of the paper that reports this interaction (PubMedID 30208514)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		HECW2	CBX3
Description		HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	chromobox 3
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GO Annotations	Cellular Component	Cytoplasm Spindle Cytoskeleton Mitotic Spindle	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Euchromatin Heterochromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Pericentric Heterochromatin Spindle Senescence-associated Heterochromatin Focus Chromatin Lock Complex RNA Polymerase II Transcription Regulator Complex Site Of DNA Damage
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity	Transcription Coregulator Binding Chromatin Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Dendrite Morphogenesis	Chromatin Organization Chromatin Remodeling DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Dexamethasone Stimulus
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Response to fenofibrate (LDL cholesterol levels) ( 27002377)	Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		8 interacting genes: CBX1 CBX3 CBX5 FZR1 TP73 UBE2D2 UBE2D3 UBE2L3	42 interacting genes: ADAMTSL4 ADNP2 ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 CDC42 DNMT3B DSN1 GDF15 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 HTR2C KLF11 L3MBTL1 LAP3 LBR LIG1 MGA MIS12 MKI67 MRPL12 NSD3 PIM1 RAD54L2 SP100 STK16 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF280D ZNF496
Entrez ID		57520	11335
HPRD ID		17099	05130
Ensembl ID		ENSG00000138411	ENSG00000122565
Uniprot IDs		A0A2R8Y6F3 Q9P2P5	A4D177 B8ZZ43 Q13185
PDB IDs		2LFE	2L11 3DM1 3KUP 3TZD 5T1I 6HW2 8JZW
Enriched GO Terms of Interacting Partners?		DNA Damage Response Ubiquitin Conjugating Enzyme Activity Pericentric Heterochromatin Protein K11-linked Ubiquitination Site Of DNA Damage Heterochromatin Protein Polyubiquitination Ubiquitin-protein Transferase Activator Activity Nucleoplasm Chromocenter Cellular Response To Stress Histone Methyltransferase Binding Heterochromatin Formation Chromosome, Centromeric Region Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Regulation Of Protein Targeting To Mitochondrion Epigenetic Regulation Of Gene Expression Cellular Response To Glucocorticoid Stimulus Post-translational Protein Modification Nucleus Cellular Response To Corticosteroid Stimulus Protein Autoubiquitination Enzyme Binding Cellular Response To Steroid Hormone Stimulus Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Macromolecule Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Primary Metabolic Process Positive Regulation Of Lung Ciliated Cell Differentiation Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Chromatin Binding Regulation Of RNA Metabolic Process Proteolysis DNA Repair Chromatin Lock Complex DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Post-translational Protein Modification Response To Glucocorticoid	Chromatin Remodeling Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of RNA Metabolic Process DNA Binding Heterochromatin Regulation Of Mitotic Cell Cycle Chromo Shadow Domain Binding Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Chromocenter Chromosome Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Nuclear Division Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Regulation Of Nuclear Division Nuclear Body Regulation Of Cell Cycle Spindle Midzone MIS12/MIND Type Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Kinetochore Chromosome, Centromeric Region Regulation Of Cell Cycle Process Structural Constituent Of Chromatin Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Protein-containing Complex Chromosome Passenger Complex Attachment Of Spindle Microtubules To Kinetochore Protein-DNA Complex Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleosome Assembly Negative Regulation Of Protein Export From Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Protein Heterodimerization Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process
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