NEK9 and NEK6

Number of citations of the paper that reports this interaction (PMID 12101123)
41

Data Source:
HPRD (in vitro, in vivo)

		NEK9	NEK6
Gene Name		NIMA-related kinase 9	NIMA-related kinase 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Cytosol Microtubule Nuclear Speck
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Signal Transducer Activity Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Cell Division	Mitotic Cell Cycle Cytokinesis Protein Phosphorylation Apoptotic Process Chromosome Segregation Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Signal Transduction Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition G2 DNA Damage Checkpoint Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Spindle Assembly Regulation Of Cellular Senescence
Pathways		Mitotic Prophase Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown Nuclear Pore Complex (NPC) Disassembly Cell Cycle, Mitotic M Phase	Mitotic Prophase Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown Nuclear Pore Complex (NPC) Disassembly Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Cognitive performance ( 20125193)
Protein-Protein Interactions		7 interactors: BICD2 MBP NEK6 NEK7 RAN SSRP1 SUPT16H	42 interactors: AES ANKRA2 ARHGAP33 ARRB1 ATF4 CCDC36 CCDC85B CDC42 CDK7 CIR1 ERCC6L2 FAM208B HSD17B14 IKZF1 IKZF3 INCA1 KCTD5 KRT31 KRT40 LNX1 LZTS2 NECAB2 NEK9 PAK6 PHF1 PIN1 PRAM1 PRDX3 PTN RBBP6 RPS6KB1 RPS7 SGK1 SMAD4 SMURF2 TCF4 TGFBR1 TNK2 TRIM23 TRIM27 TRIP4 XIAP
Entrez ID		91754	10783
HPRD ID		11386	05348
Ensembl ID		ENSG00000119638	ENSG00000119408
Uniprot IDs		Q6PKF2 Q8TD19	Q9HC98
PDB IDs		3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Organization Spindle Organization Organelle Organization Microtubule-based Process Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Cytoskeleton Organization Regulation Of Viral Transcription Cell Division Positive Regulation Of Viral Process Spindle Assembly DNA-templated Transcription, Elongation Viral Process Cytokinesis Ribosomal Small Subunit Export From Nucleus Defense Response To Nematode Minus-end-directed Organelle Transport Along Microtubule Regulation Of Viral Process Cellular Response To DNA Damage Stimulus Response To Nematode Ribosomal Large Subunit Export From Nucleus Cell Cycle Process Ribosomal Subunit Export From Nucleus DNA Metabolic Process DNA Replication Mitotic Nuclear Division Microtubule Anchoring At Microtubule Organizing Center Cellular Protein Complex Localization Nucleosome Disassembly Negative Regulation Of Interleukin-10 Production Cell Cycle Protein Complex Localization Regulation Of Mitotic Cell Cycle Positive Regulation Of Interleukin-4 Production Positive Regulation Of Macromolecule Biosynthetic Process Response To Mercury Ion Regulation Of Cellular Senescence Cellular Response To Stress Positive Regulation Of Gene Expression Organelle Assembly Intracellular Transport Of Virus Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Interleukin-4 Production G2 DNA Damage Checkpoint Mitotic Nuclear Envelope Disassembly Response To Stress Substantia Nigra Development Protein Export From Nucleus Androgen Receptor Signaling Pathway	Regulation Of Metabolic Process Regulation Of Cell Proliferation Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process RNA Biosynthetic Process Regulation Of Catalytic Activity Regulation Of Apoptotic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Regulation Of Binding Regulation Of Phosphorylation Negative Regulation Of Gene Expression Regulation Of Protein Binding Regulation Of Protein Phosphorylation Regulation Of Growth Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Protein Modification Process Cellular Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Signal Transduction Response To Stress Cellular Protein Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Ubiquitination Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Protein Modification By Small Protein Conjugation RNA Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Signaling Negative Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Endothelial Cell Activation Wnt Signaling Pathway
Tagcloud ?		adenocarcinoma broad crucial cycle deficient depletion elimination encoding exhibited g1 ideal inactivated lacking microrna network nima p53 poorer predominantly prognoses promotes regulator regulators represents repression resultant screen selectively senescence	23a abolishes attenuated attenuates berberine biogenesis chromatin detecting g2 gadd45alpha hcc hepatocellular immunoblotting mature mediate mediating microrna mir monitored onto p21 precursor prediction reveals suppress suppressive transcript upon validation
Tagcloud (Difference) ?		adenocarcinoma broad crucial cycle deficient depletion elimination encoding exhibited g1 ideal inactivated lacking network nima p53 poorer predominantly prognoses promotes regulator regulators represents repression resultant screen selectively senescence	23a abolishes attenuated attenuates berberine biogenesis chromatin detecting g2 gadd45alpha hcc hepatocellular immunoblotting mature mediate mediating mir monitored onto p21 precursor prediction reveals suppress suppressive transcript upon validation
Tagcloud (Intersection) ?		microrna